Probiotic potential risk score
| ARGs | VFs | PGs | PPRS |
|---|---|---|---|
| 0 | 25 | 33 | 41.40 |
PPRS is classified as low-risk (≤4), medium-risk (4-6), and high-risk (≥6).
Antibiotic resistance genes
Comprehensive Antibiotic Resistance Database (CARD)
| Query ID | Begin | End | ARO name | ARO accession | CARD name | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
RGI v6.0.3 (Database: CARD Variants v4.0.2, Nov. 2023 release)
ResFinder
| Query ID | Begin | End | Resistance gene | Phenotype | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|
| No hit found | |||||||
ResFinder v4.6.0 (Database: resfinder_db, Aug. 2024 release)
AMRFinderPlus
| Query ID | Begin | End | Gene symbol | Sequence name | Method | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
AMRFinderPlus v4.0.3 (Database: Oct. 2024 release)
Virulence factors
Virulence Factor Database (VFDB)
| Query ID | qstart | qend | Gene name | e-value | VF name | VF category | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|---|
| NAJKPJJO_53 | 16196 | 17002 | STR_RS06900 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011227429 |
| NAJKPJJO_53 | 17002 | 17943 | STR_RS06905 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011227430 |
| NAJKPJJO_53 | 11487 | 13232 | STR_RS06885 | 0.0 | Capsule | Immune modulation | 99.94 | 100.00 | WP_011227426 |
| NAJKPJJO_53 | 24007 | 24858 | rfbD | 0.0 | Capsule | Immune modulation | 99.88 | 100.00 | WP_014621820 |
| NAJKPJJO_53 | 17940 | 19088 | STR_RS06910 | 0.0 | Capsule | Immune modulation | 99.83 | 100.00 | WP_011227431 |
| NAJKPJJO_53 | 13336 | 14976 | STER_RS07050 | 0.0 | Capsule | Immune modulation | 99.82 | 96.47 | WP_041827753 |
| NAJKPJJO_104 | 238 | 1077 | cbpD | 0.0 | Autolysin | Exoenzyme | 99.76 | 100.00 | WP_011226733 |
| NAJKPJJO_53 | 14994 | 16196 | STR_RS06895 | 0.0 | Capsule | Immune modulation | 99.75 | 100.00 | WP_011227428 |
| NAJKPJJO_82 | 61289 | 61882 | STR_RS05880 | 0.0 | Capsule | Immune modulation | 99.66 | 100.00 | WP_011226149 |
| NAJKPJJO_53 | 13336 | 14976 | STR_RS06890 | 0.0 | Capsule | Immune modulation | 99.63 | 96.47 | WP_041827077 |
| NAJKPJJO_50 | 77918 | 79576 | fbp54 | 0.0 | FBPs | Adherence | 99.58 | 100.00 | WP_011227179 |
| NAJKPJJO_82 | 61289 | 61882 | STER_RS06030 | 0.0 | Capsule | Immune modulation | 99.50 | 100.00 | WP_011226149 |
| NAJKPJJO_53 | 14994 | 16196 | STER_RS07055 | 0.0 | Capsule | Immune modulation | 99.50 | 100.00 | WP_011681436 |
| NAJKPJJO_53 | 16196 | 17002 | STER_RS07060 | 0.0 | Capsule | Immune modulation | 99.50 | 100.00 | WP_011681437 |
| NAJKPJJO_82 | 61289 | 61882 | STU_RS15260 | 0.0 | Capsule | Immune modulation | 99.50 | 100.00 | WP_011226149 |
| NAJKPJJO_82 | 25761 | 26522 | srtA | 0.0 | Sortase A | Exoenzyme | 99.47 | 100.00 | - |
| NAJKPJJO_53 | 17002 | 17943 | STER_RS07065 | 0.0 | Capsule | Immune modulation | 99.47 | 100.00 | WP_011681438 |
| NAJKPJJO_82 | 60420 | 61289 | rfbA | 0.0 | Capsule | Immune modulation | 99.31 | 100.00 | WP_011681286 |
| NAJKPJJO_53 | 17940 | 19088 | STER_RS07070 | 0.0 | Capsule | Immune modulation | 99.04 | 100.00 | WP_011681439 |
| NAJKPJJO_1 | 3340 | 4071 | STU_RS14645 | 0.0 | Capsule | Immune modulation | 98.91 | 100.00 | WP_011226048 |
| NAJKPJJO_78 | 458 | 1873 | STER_RS05250 | 0.0 | Capsule | Immune modulation | 98.87 | 100.00 | WP_011681165 |
| NAJKPJJO_70 | 52093 | 52883 | cshA | 0.0 | Cell surface hydrophobicity proteins | Adherence | 98.86 | 100.00 | - |
| NAJKPJJO_1 | 3340 | 4071 | STR_RS05260 | 0.0 | Capsule | Immune modulation | 98.77 | 100.00 | WP_011227248 |
| NAJKPJJO_1 | 3340 | 4071 | STER_RS05315 | 0.0 | Capsule | Immune modulation | 98.63 | 100.00 | WP_011681176 |
| NAJKPJJO_53 | 11487 | 13232 | STER_RS07045 | 0.0 | Capsule | Immune modulation | 98.28 | 100.00 | WP_011681434 |
| NAJKPJJO_1 | 1889 | 2629 | STU_RS14635 | 0.0 | Capsule | Immune modulation | 98.11 | 100.00 | WP_011226046 |
| NAJKPJJO_53 | 22627 | 23886 | STER_RS07100 | 0.0 | Capsule | Immune modulation | 97.78 | 100.00 | WP_011681445 |
| NAJKPJJO_1 | 4072 | 5532 | STER_RS05320 | 0.0 | Capsule | Immune modulation | 97.74 | 100.00 | WP_011681177 |
| NAJKPJJO_1 | 1889 | 2629 | STER_RS05305 | 0.0 | Capsule | Immune modulation | 97.44 | 100.00 | WP_011681174 |
| NAJKPJJO_1 | 1894 | 2629 | STR_RS05250 | 0.0 | Capsule | Immune modulation | 97.15 | 98.13 | WP_011227246 |
| NAJKPJJO_1 | 4072 | 5532 | STU_RS14650 | 0.0 | Capsule | Immune modulation | 96.99 | 100.21 | WP_011226049 |
| NAJKPJJO_1 | 4072 | 5532 | STR_RS05265 | 0.0 | Capsule | Immune modulation | 96.85 | 100.21 | WP_041827043 |
| NAJKPJJO_1 | 2639 | 3331 | STR_RS05255 | 0.0 | Capsule | Immune modulation | 95.67 | 100.00 | WP_011227247 |
| NAJKPJJO_1 | 2639 | 3331 | STU_RS14640 | 0.0 | Capsule | Immune modulation | 95.67 | 100.00 | WP_011226047 |
| NAJKPJJO_1 | 464 | 1831 | STU_RS14630 | 0.0 | Capsule | Immune modulation | 94.96 | 100.00 | WP_011226045 |
| NAJKPJJO_1 | 466 | 1831 | STER_RS05300 | 0.0 | Capsule | Immune modulation | 94.37 | 99.78 | WP_011681173 |
| NAJKPJJO_1 | 2639 | 3331 | STER_RS05310 | 0.0 | Capsule | Immune modulation | 89.75 | 100.00 | WP_011681175 |
| NAJKPJJO_97 | 28375 | 29678 | eno | 0.0 | Streptococcal enolase | Exoenzyme | 88.02 | 99.54 | WP_000022832 |
| NAJKPJJO_79 | 211 | 1221 | plr/gapA | 0.0 | Streptococcal plasmin receptor/GAPDH | Adherence | 86.92 | 99.51 | WP_002986042 |
| NAJKPJJO_53 | 16196 | 17002 | SGO_RS05020 | 0.0 | Capsule | Immune modulation | 82.90 | 100.00 | WP_012000440 |
| NAJKPJJO_43 | 62906 | 64189 | tig/ropA | 0.0 | Trigger factor | Stress survival | 80.73 | 99.77 | WP_000107753 |
| NAJKPJJO_82 | 62311 | 63357 | rfbB | 0.0 | Capsule | Immune modulation | 80.71 | 100.00 | WP_009659423 |
| NAJKPJJO_53 | 21932 | 22630 | STER_RS07095 | 6.91e-155 | Capsule | Immune modulation | 81.29 | 70.35 | WP_011681444 |
| NAJKPJJO_53 | 21112 | 21578 | STER_RS07085 | 0.0 | Capsule | Immune modulation | 94.02 | 65.13 | WP_011681442 |
| NAJKPJJO_53 | 15459 | 16196 | SGO_RS05025 | 0.0 | Capsule | Immune modulation | 85.09 | 60.29 | WP_012000441 |
BLASTN v2.16.0 (Database: VFDB, Dec. 2024 release)
VirulenceFinder
| Query ID | Begin | End | Database | Virulence factor | Protein function | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
VirulenceFinder v2.0. 4 (Database: virulencefinder_db, Feb . 2024 release)
Pathogenic genes
PHI-base
| Query ID | qstart | qend | Gene name | e-value | Function | Identity | Coverage | Gene ID |
|---|---|---|---|---|---|---|---|---|
| NAJKPJJO_82 | 23074 | 22091 | ldh(Sp_1220) | 0.0 | L-lactate dehydrogenase | 94.82 | 100.00 | AAK75326 |
| NAJKPJJO_99 | 72850 | 73923 | MntE | 0.0 | manganese homeostasis | 94.41 | 99.72 | ABF32167 |
| NAJKPJJO_53 | 180156 | 182459 | pfl2(Sp_0459) | 0.0 | formate acetyltransferase | 92.97 | 99.22 | AAK74619 |
| NAJKPJJO_73 | 7139 | 6171 | spr0084 | 0.0 | pathogenitcity related | 92.88 | 98.48 | AAK98888 |
| NAJKPJJO_34 | 68007 | 69488 | SPD_0310 | 0.0 | UPF0371 protein SPD_0310 | 92.11 | 100.00 | ABJ54480 |
| NAJKPJJO_55 | 6128 | 8374 | metE | 0.0 | methionine biosynthesis enzymes | 91.99 | 100.00 | AAK74738 |
| NAJKPJJO_76 | 1889 | 891 | recA | 0.0 | DNA recombination and repair | 91.29 | 85.82 | AAL00560 |
| NAJKPJJO_5 | 15293 | 14322 | prsA2 | 0.0 | ribose-phosphate pyrophosphokinase | 90.12 | 100.00 | ABF36968 |
| NAJKPJJO_53 | 64655 | 63504 | potA | 0.0 | ABC transporter ATP-binding protein-spermidine/putrescine transport | 89.06 | 99.74 | AAL00050 |
| NAJKPJJO_53 | 36658 | 34670 | uvrB | 0.0 | excinuclease ABC, B subunit | 88.99 | 100.00 | AE014259_2 |
| NAJKPJJO_82 | 39269 | 40999 | ptsI | 0.0 | phosphoenolpyruvate-protein phosphotransferase | 87.69 | 100.00 | AAK34199 |
| NAJKPJJO_101 | 62925 | 61447 | IMPDH | 0.0 | inosine-5'-monophosphate dehydrogenase | 87.42 | 100.00 | ADE32434 |
| NAJKPJJO_97 | 29678 | 28377 | Eno | 0.0 | enolase | 86.21 | 99.77 | ABP90468 |
| NAJKPJJO_101 | 47729 | 45837 | gidA | 0.0 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme | 85.89 | 98.90 | ABP91129 |
| NAJKPJJO_55 | 11299 | 9590 | PGM | 0.0 | phosphoglucomutase | 83.89 | 99.65 | ACH87041 |
| NAJKPJJO_2 | 2070 | 1060 | pdh | 0.0 | pyruvate dehydrogenase | 83.09 | 99.70 | ABP91006 |
| NAJKPJJO_50 | 43543 | 44904 | mnmE | 0.0 | central tRNA-modifying GTPase | 82.02 | 99.56 | ABP90420 |
| NAJKPJJO_69 | 4718 | 6610 | PepO | 0.0 | endopeptidase | 80.19 | 100.00 | ABF32980 |
| NAJKPJJO_97 | 44119 | 43229 | bglB | 5.04e-179 | putative phospho--glucosidase | 88.22 | 99.66 | AAK33487 |
| NAJKPJJO_77 | 41014 | 41952 | SP_0676 | 2.32e-169 | transcription facot | 81.47 | 97.20 | AAK74821 |
| NAJKPJJO_55 | 8566 | 9423 | metF | 7.89e-167 | methionine biosynthesis enzymes | 86.36 | 99.31 | AAK74739 |
| NAJKPJJO_70 | 24384 | 23680 | covR | 1.01e-131 | responder protein | 84.68 | 100.00 | AAK71319 |
| NAJKPJJO_34 | 34276 | 33605 | rr01 | 1.80e-127 | response regulator | 84.82 | 99.56 | CAB54566 |
| NAJKPJJO_70 | 24384 | 23680 | walR | 7.23e-122 | DNA-binding response regulator | 80.85 | 100.00 | ANC99504 |
| NAJKPJJO_49 | 9969 | 9283 | CovR | 1.40e-119 | serves to repress GAS virulence factor-encoding genes | 80.79 | 100.00 | ACE75886 |
| NAJKPJJO_55 | 15254 | 15922 | CiaR | 1.86e-119 | two-component response regulator | 84.31 | 99.55 | AAK74935 |
| NAJKPJJO_55 | 15254 | 15925 | ciaR | 1.83e-117 | two component system response regulator | 82.14 | 99.12 | AIK75708 |
| NAJKPJJO_76 | 615 | 220 | SpxA2 | 2.40e-76 | transcriptional regulator | 90.91 | 100.00 | ERL21461 |
| NAJKPJJO_50 | 32183 | 31782 | SpxA1 | 1.89e-67 | transcriptional regulator | 80.60 | 100.00 | ERL19273 |
| NAJKPJJO_51 | 14797 | 15084 | spr0479 | 3.08e-49 | essential gene | 86.46 | 98.97 | AAK99283 |
| NAJKPJJO_68 | 60793 | 61047 | spr1327 | 1.05e-45 | essential gene | 95.29 | 100.00 | AAL00131 |
| NAJKPJJO_101 | 14091 | 14354 | spr0175 | 4.30e-42 | pathogenitcity related | 84.09 | 100.00 | AAK98979 |
| NAJKPJJO_101 | 14894 | 15184 | spr0177 | 2.52e-37 | essential gene | 81.00 | 98.02 | AAK98981 |
| NAJKPJJO_43 | 62748 | 62248 | RopE (M5005_Spy_1611) | 1.76e-76 | probable DNA-directed RNA polymerase subunit delta | 81.44 | 87.43 | AAK34603 |
| NAJKPJJO_53 | 180156 | 182453 | PFL (B9H01_RS01125) | 0.0 | formate C-acetyltransferase | 82.94 | 98.08 | MYN69560 |
| NAJKPJJO_69 | 19189 | 20208 | ilvC (SPD_0406) | 0.0 | ketol-acid reductoisomerase (NADP(+)) | 96.47 | 100.00 | ABJ55451 |
BLASTX v2.16.0 (Database: PHI base v4.16, May. 2024 release)
Plasmid
PlasmidFinder
| Query ID | Begin | End | Plasmid | Query / Template | Identity | Accession no. |
|---|---|---|---|---|---|---|
| No hit found | ||||||
PlasmidFinder v 2.1.6 (Database: plasmidfinder_db v 2.2.0 , Nov. 2024 release)
PlasmidHunter
| Query ID | Prediction | Chromosome | Plasmid |
|---|---|---|---|
| NAJKPJJO_1 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_2 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_3 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_4 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_5 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_7 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_8 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_10 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_11 | 1.0 | 0.0 | 1.0 |
| NAJKPJJO_14 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_17 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_18 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_20 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_23 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_24 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_26 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_27 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_28 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_34 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_40 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_43 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_48 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_49 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_50 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_51 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_52 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_53 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_54 | 1.0 | 0.0 | 1.0 |
| NAJKPJJO_55 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_56 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_57 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_58 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_59 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_61 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_63 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_65 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_66 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_68 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_69 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_70 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_71 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_72 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_73 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_75 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_76 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_77 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_78 | 1.0 | 0.0 | 1.0 |
| NAJKPJJO_79 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_80 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_81 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_82 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_83 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_85 | 1.0 | 0.0 | 1.0 |
| NAJKPJJO_87 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_88 | 1.0 | 0.0 | 1.0 |
| NAJKPJJO_97 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_99 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_100 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_101 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_104 | 0.0 | 1.0 | 0.0 |
| NAJKPJJO_106 | 0.0 | 1.0 | 0.0 |
PlasmidHunter v 1.4.5 (Database: May. 2024 release)
Prophage
Phigaro
| Query ID | Begin | End | Transposable | Taxonomy | pVOGs |
|---|---|---|---|---|---|
| No hit found | |||||
Phigaro v2.4.0 (Database: Jan. 2024 release)