Probiotic potential risk score
| ARGs | VFs | PGs | PPRS |
|---|---|---|---|
| 0 | 22 | 32 | 38.83 |
PPRS is classified as low-risk (≤4), medium-risk (4-6), and high-risk (≥6).
Antibiotic resistance genes
Comprehensive Antibiotic Resistance Database (CARD)
| Query ID | Begin | End | ARO name | ARO accession | CARD name | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
RGI v6.0.3 (Database: CARD Variants v4.0.2, Nov. 2023 release)
ResFinder
| Query ID | Begin | End | Resistance gene | Phenotype | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|
| No hit found | |||||||
ResFinder v4.6.0 (Database: resfinder_db, Aug. 2024 release)
AMRFinderPlus
| Query ID | Begin | End | Gene symbol | Sequence name | Method | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
AMRFinderPlus v4.0.3 (Database: Oct. 2024 release)
Virulence factors
Virulence Factor Database (VFDB)
| Query ID | qstart | qend | Gene name | e-value | VF name | VF category | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|---|
| GELKEFNP_77 | 31924 | 32517 | STR_RS05880 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011226149 |
| GELKEFNP_11 | 13978 | 14670 | STU_RS14640 | 0.0 | Capsule | Immune modulation | 99.86 | 100.00 | WP_011226047 |
| GELKEFNP_77 | 31924 | 32517 | STER_RS06030 | 0.0 | Capsule | Immune modulation | 99.83 | 100.00 | WP_011226149 |
| GELKEFNP_77 | 31924 | 32517 | STU_RS15260 | 0.0 | Capsule | Immune modulation | 99.83 | 100.00 | WP_011226149 |
| GELKEFNP_4 | 115623 | 116882 | STER_RS07100 | 0.0 | Capsule | Immune modulation | 99.76 | 100.00 | WP_011681445 |
| GELKEFNP_10 | 9142 | 9981 | cbpD | 0.0 | Autolysin | Exoenzyme | 99.64 | 100.00 | WP_011226733 |
| GELKEFNP_4 | 117873 | 118841 | STER_RS07090 | 0.0 | Capsule | Immune modulation | 99.59 | 100.00 | WP_011681443 |
| GELKEFNP_40 | 15205 | 16863 | fbp54 | 0.0 | FBPs | Adherence | 99.52 | 100.00 | WP_011227179 |
| GELKEFNP_4 | 116879 | 117855 | STER_RS07095 | 0.0 | Capsule | Immune modulation | 99.49 | 99.90 | WP_011681444 |
| GELKEFNP_11 | 13978 | 14670 | STR_RS05255 | 0.0 | Capsule | Immune modulation | 99.28 | 100.00 | WP_011227247 |
| GELKEFNP_77 | 31055 | 31924 | rfbA | 0.0 | Capsule | Immune modulation | 99.19 | 100.00 | WP_011681286 |
| GELKEFNP_11 | 13238 | 13969 | STER_RS05315 | 0.0 | Capsule | Immune modulation | 99.18 | 100.00 | WP_011681176 |
| GELKEFNP_77 | 76545 | 77335 | cshA | 0.0 | Cell surface hydrophobicity proteins | Adherence | 99.11 | 100.00 | - |
| GELKEFNP_96 | 2945 | 3706 | srtA | 0.0 | Sortase A | Exoenzyme | 99.08 | 100.00 | - |
| GELKEFNP_11 | 13238 | 13969 | STU_RS14645 | 0.0 | Capsule | Immune modulation | 98.63 | 100.00 | WP_011226048 |
| GELKEFNP_11 | 13238 | 13969 | STR_RS05260 | 0.0 | Capsule | Immune modulation | 98.50 | 100.00 | WP_011227248 |
| GELKEFNP_4 | 118843 | 119558 | STER_RS07085 | 0.0 | Capsule | Immune modulation | 98.18 | 99.86 | WP_011681442 |
| GELKEFNP_4 | 119904 | 120674 | STER_RS07075 | 0.0 | Capsule | Immune modulation | 97.92 | 99.23 | WP_011681440 |
| GELKEFNP_11 | 11777 | 13237 | STER_RS05320 | 0.0 | Capsule | Immune modulation | 97.88 | 100.00 | WP_011681177 |
| GELKEFNP_11 | 11777 | 13237 | STU_RS14650 | 0.0 | Capsule | Immune modulation | 96.99 | 100.21 | WP_011226049 |
| GELKEFNP_11 | 15480 | 16845 | STER_RS05300 | 0.0 | Capsule | Immune modulation | 96.41 | 99.85 | WP_011681173 |
| GELKEFNP_4 | 114653 | 115504 | rfbD | 0.0 | Capsule | Immune modulation | 96.36 | 100.00 | WP_014621820 |
| GELKEFNP_11 | 11777 | 13237 | STR_RS05265 | 0.0 | Capsule | Immune modulation | 96.17 | 100.21 | WP_041827043 |
| GELKEFNP_11 | 14680 | 15423 | STER_RS05305 | 0.0 | Capsule | Immune modulation | 95.70 | 100.13 | WP_011681174 |
| GELKEFNP_11 | 14680 | 15423 | STU_RS14635 | 0.0 | Capsule | Immune modulation | 95.56 | 100.13 | WP_011226046 |
| GELKEFNP_11 | 14680 | 15418 | STR_RS05250 | 0.0 | Capsule | Immune modulation | 94.72 | 98.27 | WP_011227246 |
| GELKEFNP_11 | 15480 | 16847 | STU_RS14630 | 0.0 | Capsule | Immune modulation | 93.28 | 100.00 | WP_011226045 |
| GELKEFNP_11 | 13978 | 14670 | STER_RS05310 | 0.0 | Capsule | Immune modulation | 89.75 | 100.00 | WP_011681175 |
| GELKEFNP_56 | 28723 | 30026 | eno | 0.0 | Streptococcal enolase | Exoenzyme | 88.17 | 99.54 | WP_000022832 |
| GELKEFNP_12 | 186 | 1196 | plr/gapA | 0.0 | Streptococcal plasmin receptor/GAPDH | Adherence | 86.92 | 99.51 | WP_002986042 |
| GELKEFNP_69 | 2569 | 3852 | tig/ropA | 0.0 | Trigger factor | Stress survival | 80.58 | 99.77 | WP_000107753 |
| GELKEFNP_77 | 32946 | 33992 | rfbB | 0.0 | Capsule | Immune modulation | 80.42 | 100.00 | WP_009659423 |
| GELKEFNP_11 | 24424 | 25007 | SPD_RS01775 | 3.51e-145 | Capsule | Immune modulation | 82.73 | 96.20 | WP_001819836 |
BLASTN v2.16.0 (Database: VFDB, Dec. 2024 release)
VirulenceFinder
| Query ID | Begin | End | Database | Virulence factor | Protein function | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
VirulenceFinder v2.0. 4 (Database: virulencefinder_db, Feb . 2024 release)
Pathogenic genes
PHI-base
| Query ID | qstart | qend | Gene name | e-value | Function | Identity | Coverage | Gene ID |
|---|---|---|---|---|---|---|---|---|
| GELKEFNP_96 | 6393 | 7376 | ldh(Sp_1220) | 0.0 | L-lactate dehydrogenase | 94.82 | 100.00 | AAK75326 |
| GELKEFNP_45 | 6714 | 7787 | MntE | 0.0 | manganese homeostasis | 94.41 | 99.72 | ABF32167 |
| GELKEFNP_56 | 112275 | 111307 | spr0084 | 0.0 | pathogenitcity related | 93.19 | 98.48 | AAK98888 |
| GELKEFNP_97 | 12913 | 10610 | pfl2(Sp_0459) | 0.0 | formate acetyltransferase | 93.10 | 99.22 | AAK74619 |
| GELKEFNP_7 | 13822 | 16068 | metE | 0.0 | methionine biosynthesis enzymes | 91.99 | 100.00 | AAK74738 |
| GELKEFNP_93 | 49701 | 51182 | SPD_0310 | 0.0 | UPF0371 protein SPD_0310 | 91.90 | 100.00 | ABJ54480 |
| GELKEFNP_15 | 1902 | 910 | recA | 0.0 | DNA recombination and repair | 91.24 | 85.31 | AAL00560 |
| GELKEFNP_41 | 15299 | 14328 | prsA2 | 0.0 | ribose-phosphate pyrophosphokinase | 90.12 | 100.00 | ABF36968 |
| GELKEFNP_4 | 73569 | 74720 | potA | 0.0 | ABC transporter ATP-binding protein-spermidine/putrescine transport | 89.06 | 99.74 | AAL00050 |
| GELKEFNP_4 | 101584 | 103572 | uvrB | 0.0 | excinuclease ABC, B subunit | 88.99 | 100.00 | AE014259_2 |
| GELKEFNP_77 | 9903 | 11633 | ptsI | 0.0 | phosphoenolpyruvate-protein phosphotransferase | 87.69 | 100.00 | AAK34199 |
| GELKEFNP_85 | 63446 | 61968 | IMPDH | 0.0 | inosine-5'-monophosphate dehydrogenase | 87.22 | 100.00 | ADE32434 |
| GELKEFNP_56 | 30026 | 28725 | Eno | 0.0 | enolase | 86.21 | 99.77 | ABP90468 |
| GELKEFNP_85 | 48250 | 46358 | gidA | 0.0 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme | 86.05 | 98.90 | ABP91129 |
| GELKEFNP_7 | 18993 | 17284 | PGM | 0.0 | phosphoglucomutase | 83.89 | 99.65 | ACH87041 |
| GELKEFNP_36 | 18793 | 19803 | pdh | 0.0 | pyruvate dehydrogenase | 83.09 | 99.70 | ABP91006 |
| GELKEFNP_43 | 9072 | 7711 | mnmE | 0.0 | central tRNA-modifying GTPase | 82.24 | 99.56 | ABP90420 |
| GELKEFNP_31 | 41913 | 40021 | PepO | 0.0 | endopeptidase | 80.03 | 100.00 | ABF32980 |
| GELKEFNP_56 | 44456 | 43566 | bglB | 9.79e-180 | putative phospho--glucosidase | 88.89 | 99.66 | AAK33487 |
| GELKEFNP_9 | 13345 | 12407 | SP_0676 | 7.96e-170 | transcription facot | 81.47 | 97.20 | AAK74821 |
| GELKEFNP_7 | 16260 | 17117 | metF | 1.15e-166 | methionine biosynthesis enzymes | 86.36 | 99.31 | AAK74739 |
| GELKEFNP_77 | 104920 | 105624 | covR | 7.45e-132 | responder protein | 85.11 | 100.00 | AAK71319 |
| GELKEFNP_93 | 21610 | 20939 | rr01 | 1.38e-126 | response regulator | 84.38 | 99.56 | CAB54566 |
| GELKEFNP_77 | 104920 | 105624 | walR | 3.73e-122 | DNA-binding response regulator | 81.28 | 100.00 | ANC99504 |
| GELKEFNP_7 | 22947 | 23615 | CiaR | 2.70e-119 | two-component response regulator | 84.31 | 99.55 | AAK74935 |
| GELKEFNP_37 | 49029 | 49715 | CovR | 3.06e-119 | serves to repress GAS virulence factor-encoding genes | 80.79 | 100.00 | ACE75886 |
| GELKEFNP_7 | 22947 | 23618 | ciaR | 2.66e-117 | two component system response regulator | 82.14 | 99.12 | AIK75708 |
| GELKEFNP_15 | 613 | 218 | SpxA2 | 2.39e-76 | transcriptional regulator | 90.91 | 100.00 | ERL21461 |
| GELKEFNP_3 | 14112 | 14399 | spr0479 | 3.43e-49 | essential gene | 86.46 | 98.97 | AAK99283 |
| GELKEFNP_65 | 19248 | 19502 | spr1327 | 4.33e-46 | essential gene | 95.29 | 100.00 | AAL00131 |
| GELKEFNP_85 | 14624 | 14887 | spr0175 | 4.32e-42 | pathogenitcity related | 84.09 | 100.00 | AAK98979 |
| GELKEFNP_85 | 15451 | 15717 | spr0177 | 7.63e-34 | essential gene | 84.27 | 88.12 | AAK98981 |
| GELKEFNP_69 | 4010 | 4510 | RopE (M5005_Spy_1611) | 1.71e-76 | probable DNA-directed RNA polymerase subunit delta | 81.44 | 87.43 | AAK34603 |
| GELKEFNP_97 | 12913 | 10616 | PFL (B9H01_RS01125) | 0.0 | formate C-acetyltransferase | 83.07 | 98.08 | MYN69560 |
| GELKEFNP_31 | 27454 | 26435 | ilvC (SPD_0406) | 0.0 | ketol-acid reductoisomerase (NADP(+)) | 96.47 | 100.00 | ABJ55451 |
BLASTX v2.16.0 (Database: PHI base v4.16, May. 2024 release)
Plasmid
PlasmidFinder
| Query ID | Begin | End | Plasmid | Query / Template | Identity | Accession no. |
|---|---|---|---|---|---|---|
| No hit found | ||||||
PlasmidFinder v 2.1.6 (Database: plasmidfinder_db v 2.2.0 , Nov. 2024 release)
PlasmidHunter
| Query ID | Prediction | Chromosome | Plasmid |
|---|---|---|---|
| GELKEFNP_1 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_3 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_4 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_5 | 1.0 | 0.0 | 1.0 |
| GELKEFNP_6 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_7 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_9 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_10 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_11 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_12 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_15 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_16 | 1.0 | 0.0 | 1.0 |
| GELKEFNP_19 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_20 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_22 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_23 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_24 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_25 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_27 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_28 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_29 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_30 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_31 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_32 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_33 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_34 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_35 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_36 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_37 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_38 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_39 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_40 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_41 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_42 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_43 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_44 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_45 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_46 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_47 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_56 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_65 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_66 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_67 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_69 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_77 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_85 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_91 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_93 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_94 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_95 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_96 | 0.0 | 1.0 | 0.0 |
| GELKEFNP_97 | 0.0 | 1.0 | 0.0 |
PlasmidHunter v 1.4.5 (Database: May. 2024 release)
Prophage
Phigaro
| Query ID | Begin | End | Transposable | Taxonomy | pVOGs |
|---|---|---|---|---|---|
| No hit found | |||||
Phigaro v2.4.0 (Database: Jan. 2024 release)