Probiotic potential risk score
| ARGs | VFs | PGs | PPRS |
|---|---|---|---|
| 0 | 18 | 33 | 37.59 |
PPRS is classified as low-risk (≤4), medium-risk (4-6), and high-risk (≥6).
Antibiotic resistance genes
Comprehensive Antibiotic Resistance Database (CARD)
| Query ID | Begin | End | ARO name | ARO accession | CARD name | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
RGI v6.0.3 (Database: CARD Variants v4.0.2, Nov. 2023 release)
ResFinder
| Query ID | Begin | End | Resistance gene | Phenotype | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|
| No hit found | |||||||
ResFinder v4.6.0 (Database: resfinder_db, Aug. 2024 release)
AMRFinderPlus
| Query ID | Begin | End | Gene symbol | Sequence name | Method | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
AMRFinderPlus v4.0.3 (Database: Oct. 2024 release)
Virulence factors
Virulence Factor Database (VFDB)
| Query ID | qstart | qend | Gene name | e-value | VF name | VF category | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|---|
| HBDBLILB_72 | 19478 | 20347 | rfbA | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011681286 |
| HBDBLILB_72 | 20347 | 20940 | STER_RS06030 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011226149 |
| HBDBLILB_72 | 20347 | 20940 | STR_RS05880 | 0.0 | Capsule | Immune modulation | 99.83 | 100.00 | WP_011226149 |
| HBDBLILB_72 | 20347 | 20940 | STU_RS15260 | 0.0 | Capsule | Immune modulation | 99.66 | 100.00 | WP_011226149 |
| HBDBLILB_57 | 68693 | 70351 | fbp54 | 0.0 | FBPs | Adherence | 99.58 | 100.00 | WP_011227179 |
| HBDBLILB_107 | 211 | 1050 | cbpD | 0.0 | Autolysin | Exoenzyme | 99.52 | 100.00 | WP_011226733 |
| HBDBLILB_105 | 13658 | 14389 | STER_RS05315 | 0.0 | Capsule | Immune modulation | 98.77 | 100.00 | WP_011681176 |
| HBDBLILB_90 | 52120 | 52908 | cshA | 0.0 | Cell surface hydrophobicity proteins | Adherence | 98.36 | 99.75 | - |
| HBDBLILB_92 | 28866 | 29582 | STER_RS07085 | 0.0 | Capsule | Immune modulation | 98.33 | 100.00 | WP_011681442 |
| HBDBLILB_105 | 13658 | 14389 | STU_RS14645 | 0.0 | Capsule | Immune modulation | 98.09 | 100.00 | WP_011226048 |
| HBDBLILB_105 | 13658 | 14389 | STR_RS05260 | 0.0 | Capsule | Immune modulation | 97.81 | 100.00 | WP_011227248 |
| HBDBLILB_105 | 15100 | 15840 | STER_RS05305 | 0.0 | Capsule | Immune modulation | 97.71 | 100.00 | WP_011681174 |
| HBDBLILB_92 | 35204 | 36055 | rfbD | 0.0 | Capsule | Immune modulation | 97.65 | 100.00 | WP_014621820 |
| HBDBLILB_5 | 2940 | 3701 | srtA | 0.0 | Sortase A | Exoenzyme | 97.64 | 100.00 | - |
| HBDBLILB_105 | 12202 | 13657 | STER_RS05320 | 0.0 | Capsule | Immune modulation | 97.60 | 99.66 | WP_011681177 |
| HBDBLILB_105 | 15100 | 15840 | STU_RS14635 | 0.0 | Capsule | Immune modulation | 97.57 | 100.00 | WP_011226046 |
| HBDBLILB_105 | 15100 | 15835 | STR_RS05250 | 0.0 | Capsule | Immune modulation | 97.01 | 98.13 | WP_011227246 |
| HBDBLILB_105 | 12202 | 13657 | STU_RS14650 | 0.0 | Capsule | Immune modulation | 96.84 | 99.86 | WP_011226049 |
| HBDBLILB_92 | 27744 | 28520 | STER_RS07075 | 0.0 | Capsule | Immune modulation | 96.66 | 99.87 | WP_011681440 |
| HBDBLILB_105 | 12202 | 13657 | STR_RS05265 | 0.0 | Capsule | Immune modulation | 96.08 | 99.86 | WP_041827043 |
| HBDBLILB_105 | 15897 | 17262 | STER_RS05300 | 0.0 | Capsule | Immune modulation | 95.24 | 99.85 | WP_011681173 |
| HBDBLILB_105 | 15897 | 17264 | STU_RS14630 | 0.0 | Capsule | Immune modulation | 94.30 | 100.00 | WP_011226045 |
| HBDBLILB_105 | 14398 | 15090 | STU_RS14640 | 0.0 | Capsule | Immune modulation | 93.51 | 100.00 | WP_011226047 |
| HBDBLILB_105 | 14398 | 15090 | STR_RS05255 | 0.0 | Capsule | Immune modulation | 93.22 | 100.00 | WP_011227247 |
| HBDBLILB_99 | 73180 | 74483 | eno | 0.0 | Streptococcal enolase | Exoenzyme | 88.10 | 99.46 | WP_000022832 |
| HBDBLILB_105 | 14398 | 15090 | STER_RS05310 | 0.0 | Capsule | Immune modulation | 87.16 | 100.00 | WP_011681175 |
| HBDBLILB_110 | 90 | 1100 | plr/gapA | 0.0 | Streptococcal plasmin receptor/GAPDH | Adherence | 86.54 | 99.41 | WP_002986042 |
| HBDBLILB_89 | 2307 | 3590 | tig/ropA | 0.0 | Trigger factor | Stress survival | 80.65 | 99.77 | WP_000107753 |
| HBDBLILB_72 | 21369 | 22415 | rfbB | 0.0 | Capsule | Immune modulation | 80.61 | 100.00 | WP_009659423 |
BLASTN v2.16.0 (Database: VFDB, Dec. 2024 release)
VirulenceFinder
| Query ID | Begin | End | Database | Virulence factor | Protein function | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
VirulenceFinder v2.0. 4 (Database: virulencefinder_db, Feb . 2024 release)
Pathogenic genes
PHI-base
| Query ID | qstart | qend | Gene name | e-value | Function | Identity | Coverage | Gene ID |
|---|---|---|---|---|---|---|---|---|
| HBDBLILB_5 | 6388 | 7371 | ldh(Sp_1220) | 0.0 | L-lactate dehydrogenase | 94.82 | 100.00 | AAK75326 |
| HBDBLILB_93 | 6732 | 7805 | MntE | 0.0 | manganese homeostasis | 94.41 | 99.72 | ABF32167 |
| HBDBLILB_99 | 158168 | 157200 | spr0084 | 0.0 | pathogenitcity related | 93.19 | 98.48 | AAK98888 |
| HBDBLILB_92 | 199867 | 202170 | pfl2(Sp_0459) | 0.0 | formate acetyltransferase | 92.97 | 99.22 | AAK74619 |
| HBDBLILB_27 | 21338 | 23584 | metE | 0.0 | methionine biosynthesis enzymes | 91.99 | 100.00 | AAK74738 |
| HBDBLILB_50 | 18339 | 19820 | SPD_0310 | 0.0 | UPF0371 protein SPD_0310 | 91.90 | 100.00 | ABJ54480 |
| HBDBLILB_3 | 2059 | 1067 | recA | 0.0 | DNA recombination and repair | 91.24 | 85.31 | AAL00560 |
| HBDBLILB_41 | 117 | 1088 | prsA2 | 0.0 | ribose-phosphate pyrophosphokinase | 90.12 | 100.00 | ABF36968 |
| HBDBLILB_92 | 86075 | 84924 | potA | 0.0 | ABC transporter ATP-binding protein-spermidine/putrescine transport | 89.32 | 99.74 | AAL00050 |
| HBDBLILB_92 | 49115 | 47127 | uvrB | 0.0 | excinuclease ABC, B subunit | 88.99 | 100.00 | AE014259_2 |
| HBDBLILB_103 | 9896 | 11626 | ptsI | 0.0 | phosphoenolpyruvate-protein phosphotransferase | 88.04 | 100.00 | AAK34199 |
| HBDBLILB_35 | 26991 | 28469 | IMPDH | 0.0 | inosine-5'-monophosphate dehydrogenase | 87.42 | 100.00 | ADE32434 |
| HBDBLILB_99 | 74483 | 73182 | Eno | 0.0 | enolase | 86.21 | 99.77 | ABP90468 |
| HBDBLILB_35 | 42180 | 44072 | gidA | 0.0 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme | 86.05 | 98.90 | ABP91129 |
| HBDBLILB_27 | 26509 | 24800 | PGM | 0.0 | phosphoglucomutase | 84.06 | 99.65 | ACH87041 |
| HBDBLILB_95 | 54988 | 53978 | pdh | 0.0 | pyruvate dehydrogenase | 83.09 | 99.70 | ABP91006 |
| HBDBLILB_57 | 46695 | 48056 | mnmE | 0.0 | central tRNA-modifying GTPase | 82.24 | 99.56 | ABP90420 |
| HBDBLILB_95 | 4718 | 6610 | PepO | 0.0 | endopeptidase | 80.03 | 100.00 | ABF32980 |
| HBDBLILB_99 | 88918 | 88028 | bglB | 4.87e-179 | putative phospho--glucosidase | 88.55 | 99.66 | AAK33487 |
| HBDBLILB_34 | 45836 | 46774 | SP_0676 | 6.25e-169 | transcription facot | 81.15 | 97.20 | AAK74821 |
| HBDBLILB_27 | 23776 | 24633 | metF | 4.14e-166 | methionine biosynthesis enzymes | 86.36 | 99.31 | AAK74739 |
| HBDBLILB_90 | 24440 | 23736 | covR | 2.28e-132 | responder protein | 85.53 | 100.00 | AAK71319 |
| HBDBLILB_98 | 24292 | 23621 | rr01 | 6.11e-126 | response regulator | 83.93 | 99.56 | CAB54566 |
| HBDBLILB_27 | 30463 | 31131 | CiaR | 7.57e-125 | two-component response regulator | 87.00 | 99.55 | AAK74935 |
| HBDBLILB_27 | 30463 | 31134 | ciaR | 7.38e-123 | two component system response regulator | 84.82 | 99.12 | AIK75708 |
| HBDBLILB_90 | 24440 | 23736 | walR | 9.61e-123 | DNA-binding response regulator | 82.13 | 100.00 | ANC99504 |
| HBDBLILB_102 | 7986 | 7300 | CovR | 1.29e-119 | serves to repress GAS virulence factor-encoding genes | 80.79 | 100.00 | ACE75886 |
| HBDBLILB_3 | 755 | 360 | SpxA2 | 3.65e-76 | transcriptional regulator | 90.91 | 100.00 | ERL21461 |
| HBDBLILB_57 | 35336 | 34935 | SpxA1 | 1.69e-67 | transcriptional regulator | 80.60 | 100.00 | ERL19273 |
| HBDBLILB_97 | 13208 | 13495 | spr0479 | 2.96e-49 | essential gene | 86.46 | 98.97 | AAK99283 |
| HBDBLILB_88 | 9893 | 9639 | spr1327 | 1.05e-45 | essential gene | 95.29 | 100.00 | AAL00131 |
| HBDBLILB_35 | 75824 | 75561 | spr0175 | 4.13e-42 | pathogenitcity related | 84.09 | 100.00 | AAK98979 |
| HBDBLILB_35 | 74997 | 74731 | spr0177 | 9.03e-34 | essential gene | 84.27 | 88.12 | AAK98981 |
| HBDBLILB_89 | 3748 | 4248 | RopE (M5005_Spy_1611) | 1.66e-76 | probable DNA-directed RNA polymerase subunit delta | 81.44 | 87.43 | AAK34603 |
| HBDBLILB_92 | 199867 | 202164 | PFL (B9H01_RS01125) | 0.0 | formate C-acetyltransferase | 82.94 | 98.08 | MYN69560 |
| HBDBLILB_95 | 19126 | 20145 | ilvC (SPD_0406) | 0.0 | ketol-acid reductoisomerase (NADP(+)) | 95.88 | 100.00 | ABJ55451 |
BLASTX v2.16.0 (Database: PHI base v4.16, May. 2024 release)
Plasmid
PlasmidFinder
| Query ID | Begin | End | Plasmid | Query / Template | Identity | Accession no. |
|---|---|---|---|---|---|---|
| No hit found | ||||||
PlasmidFinder v 2.1.6 (Database: plasmidfinder_db v 2.2.0 , Nov. 2024 release)
PlasmidHunter
| Query ID | Prediction | Chromosome | Plasmid |
|---|---|---|---|
| HBDBLILB_2 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_3 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_4 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_5 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_6 | 1.0 | 0.0 | 1.0 |
| HBDBLILB_11 | 1.0 | 0.0 | 1.0 |
| HBDBLILB_12 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_14 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_18 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_21 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_27 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_31 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_32 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_33 | 1.0 | 0.0 | 1.0 |
| HBDBLILB_34 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_35 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_36 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_37 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_38 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_39 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_40 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_41 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_43 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_44 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_45 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_46 | 1.0 | 0.0 | 1.0 |
| HBDBLILB_47 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_49 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_50 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_51 | 1.0 | 0.0 | 1.0 |
| HBDBLILB_52 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_53 | 1.0 | 0.0 | 1.0 |
| HBDBLILB_57 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_63 | 1.0 | 0.0 | 1.0 |
| HBDBLILB_65 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_72 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_81 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_86 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_88 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_89 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_90 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_91 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_92 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_93 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_94 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_95 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_97 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_98 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_99 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_100 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_101 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_102 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_103 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_105 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_106 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_107 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_109 | 0.0 | 1.0 | 0.0 |
| HBDBLILB_110 | 0.0 | 1.0 | 0.0 |
PlasmidHunter v 1.4.5 (Database: May. 2024 release)
Prophage
Phigaro
| Query ID | Begin | End | Transposable | Taxonomy | pVOGs |
|---|---|---|---|---|---|
| No hit found | |||||
Phigaro v2.4.0 (Database: Jan. 2024 release)