Probiotic potential risk score
| ARGs | VFs | PGs | PPRS |
|---|---|---|---|
| 0 | 23 | 33 | 40.22 |
PPRS is classified as low-risk (≤4), medium-risk (4-6), and high-risk (≥6).
Antibiotic resistance genes
Comprehensive Antibiotic Resistance Database (CARD)
| Query ID | Begin | End | ARO name | ARO accession | CARD name | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
RGI v6.0.3 (Database: CARD Variants v4.0.2, Nov. 2023 release)
ResFinder
| Query ID | Begin | End | Resistance gene | Phenotype | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|
| No hit found | |||||||
ResFinder v4.6.0 (Database: resfinder_db, Aug. 2024 release)
AMRFinderPlus
| Query ID | Begin | End | Gene symbol | Sequence name | Method | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
AMRFinderPlus v4.0.3 (Database: Oct. 2024 release)
Virulence factors
Virulence Factor Database (VFDB)
| Query ID | qstart | qend | Gene name | e-value | VF name | VF category | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|---|
| DGNHLIAC_40 | 8998 | 9591 | STER_RS06030 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011226149 |
| DGNHLIAC_41 | 4896 | 6155 | STER_RS07100 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011681445 |
| DGNHLIAC_40 | 9591 | 10460 | rfbA | 0.0 | Capsule | Immune modulation | 99.89 | 100.00 | WP_011681286 |
| DGNHLIAC_40 | 8998 | 9591 | STR_RS05880 | 0.0 | Capsule | Immune modulation | 99.83 | 100.00 | WP_011226149 |
| DGNHLIAC_40 | 8998 | 9591 | STU_RS15260 | 0.0 | Capsule | Immune modulation | 99.66 | 100.00 | WP_011226149 |
| DGNHLIAC_41 | 3923 | 4899 | STER_RS07095 | 0.0 | Capsule | Immune modulation | 99.59 | 99.90 | WP_011681444 |
| DGNHLIAC_60 | 13159 | 14817 | fbp54 | 0.0 | FBPs | Adherence | 99.58 | 100.00 | WP_011227179 |
| DGNHLIAC_47 | 11403 | 12002 | STR_RS05245 | 0.0 | Capsule | Immune modulation | 99.33 | 100.00 | WP_196767671 |
| DGNHLIAC_41 | 2937 | 3905 | STER_RS07090 | 0.0 | Capsule | Immune modulation | 99.28 | 100.00 | WP_011681443 |
| DGNHLIAC_89 | 595 | 2010 | STER_RS05250 | 0.0 | Capsule | Immune modulation | 99.15 | 100.00 | WP_011681165 |
| DGNHLIAC_108 | 25575 | 26336 | srtA | 0.0 | Sortase A | Exoenzyme | 99.08 | 100.00 | - |
| DGNHLIAC_43 | 16079 | 17047 | cbpD | 0.0 | Autolysin | Exoenzyme | 98.86 | 100.00 | WP_082302295 |
| DGNHLIAC_47 | 14332 | 15786 | STR_RS05265 | 0.0 | Capsule | Immune modulation | 98.83 | 100.00 | WP_041827043 |
| DGNHLIAC_47 | 13600 | 14331 | STER_RS05315 | 0.0 | Capsule | Immune modulation | 98.77 | 100.00 | WP_011681176 |
| DGNHLIAC_47 | 10279 | 11238 | STR_RS05240 | 0.0 | Capsule | Immune modulation | 98.54 | 100.00 | WP_041827042 |
| DGNHLIAC_47 | 13600 | 14331 | STU_RS14645 | 0.0 | Capsule | Immune modulation | 98.50 | 100.00 | WP_011226048 |
| DGNHLIAC_47 | 12154 | 12889 | STER_RS05305 | 0.0 | Capsule | Immune modulation | 98.37 | 99.33 | WP_011681174 |
| DGNHLIAC_47 | 13600 | 14331 | STR_RS05260 | 0.0 | Capsule | Immune modulation | 98.36 | 100.00 | WP_011227248 |
| DGNHLIAC_41 | 2220 | 2935 | STER_RS07085 | 0.0 | Capsule | Immune modulation | 98.32 | 99.86 | WP_011681442 |
| DGNHLIAC_47 | 14332 | 15786 | STU_RS14650 | 0.0 | Capsule | Immune modulation | 98.28 | 100.00 | WP_011226049 |
| DGNHLIAC_47 | 12140 | 12889 | STR_RS05250 | 0.0 | Capsule | Immune modulation | 98.00 | 100.00 | WP_011227246 |
| DGNHLIAC_34 | 24275 | 25070 | cshA | 0.0 | Cell surface hydrophobicity proteins | Adherence | 97.99 | 100.51 | - |
| DGNHLIAC_41 | 1104 | 1874 | STER_RS07075 | 0.0 | Capsule | Immune modulation | 97.92 | 99.23 | WP_011681440 |
| DGNHLIAC_47 | 12154 | 12889 | STU_RS14635 | 0.0 | Capsule | Immune modulation | 97.55 | 99.33 | WP_011226046 |
| DGNHLIAC_41 | 6274 | 7125 | rfbD | 0.0 | Capsule | Immune modulation | 97.30 | 100.00 | WP_014621820 |
| DGNHLIAC_47 | 14332 | 15786 | STER_RS05320 | 0.0 | Capsule | Immune modulation | 96.72 | 99.79 | WP_011681177 |
| DGNHLIAC_47 | 12899 | 13591 | STER_RS05310 | 0.0 | Capsule | Immune modulation | 89.47 | 100.00 | WP_011681175 |
| DGNHLIAC_47 | 12899 | 13591 | STU_RS14640 | 0.0 | Capsule | Immune modulation | 89.32 | 100.00 | WP_011226047 |
| DGNHLIAC_47 | 12899 | 13591 | STR_RS05255 | 0.0 | Capsule | Immune modulation | 89.03 | 100.00 | WP_011227247 |
| DGNHLIAC_107 | 96299 | 97602 | eno | 0.0 | Streptococcal enolase | Exoenzyme | 88.10 | 99.46 | WP_000022832 |
| DGNHLIAC_12 | 92 | 1102 | plr/gapA | 0.0 | Streptococcal plasmin receptor/GAPDH | Adherence | 86.64 | 99.41 | WP_002986042 |
| DGNHLIAC_115 | 5311 | 6594 | tig/ropA | 0.0 | Trigger factor | Stress survival | 80.73 | 99.77 | WP_000107753 |
| DGNHLIAC_40 | 7523 | 8569 | rfbB | 0.0 | Capsule | Immune modulation | 80.61 | 100.00 | WP_009659423 |
BLASTN v2.16.0 (Database: VFDB, Dec. 2024 release)
VirulenceFinder
| Query ID | Begin | End | Database | Virulence factor | Protein function | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
VirulenceFinder v2.0. 4 (Database: virulencefinder_db, Feb . 2024 release)
Pathogenic genes
PHI-base
| Query ID | qstart | qend | Gene name | e-value | Function | Identity | Coverage | Gene ID |
|---|---|---|---|---|---|---|---|---|
| DGNHLIAC_108 | 22888 | 21905 | ldh(Sp_1220) | 0.0 | L-lactate dehydrogenase | 94.82 | 100.00 | AAK75326 |
| DGNHLIAC_39 | 6736 | 7809 | MntE | 0.0 | manganese homeostasis | 94.41 | 99.72 | ABF32167 |
| DGNHLIAC_107 | 14002 | 14970 | spr0084 | 0.0 | pathogenitcity related | 93.19 | 98.48 | AAK98888 |
| DGNHLIAC_113 | 15570 | 13267 | pfl2(Sp_0459) | 0.0 | formate acetyltransferase | 92.97 | 99.22 | AAK74619 |
| DGNHLIAC_87 | 29784 | 27538 | metE | 0.0 | methionine biosynthesis enzymes | 91.99 | 100.00 | AAK74738 |
| DGNHLIAC_48 | 58138 | 59619 | SPD_0310 | 0.0 | UPF0371 protein SPD_0310 | 91.90 | 100.00 | ABJ54480 |
| DGNHLIAC_45 | 12613 | 13611 | recA | 0.0 | DNA recombination and repair | 91.29 | 85.82 | AAL00560 |
| DGNHLIAC_61 | 15471 | 14500 | prsA2 | 0.0 | ribose-phosphate pyrophosphokinase | 90.12 | 100.00 | ABF36968 |
| DGNHLIAC_97 | 16874 | 15723 | potA | 0.0 | ABC transporter ATP-binding protein-spermidine/putrescine transport | 89.32 | 99.74 | AAL00050 |
| DGNHLIAC_41 | 20164 | 18176 | uvrB | 0.0 | excinuclease ABC, B subunit | 88.84 | 100.00 | AE014259_2 |
| DGNHLIAC_108 | 39088 | 40818 | ptsI | 0.0 | phosphoenolpyruvate-protein phosphotransferase | 88.04 | 100.00 | AAK34199 |
| DGNHLIAC_37 | 26996 | 28474 | IMPDH | 0.0 | inosine-5'-monophosphate dehydrogenase | 87.22 | 100.00 | ADE32434 |
| DGNHLIAC_107 | 96299 | 97600 | Eno | 0.0 | enolase | 86.21 | 99.77 | ABP90468 |
| DGNHLIAC_37 | 42188 | 44080 | gidA | 0.0 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme | 86.05 | 98.90 | ABP91129 |
| DGNHLIAC_87 | 24613 | 26322 | PGM | 0.0 | phosphoglucomutase | 83.89 | 99.65 | ACH87041 |
| DGNHLIAC_36 | 2059 | 1049 | pdh | 0.0 | pyruvate dehydrogenase | 83.09 | 99.70 | ABP91006 |
| DGNHLIAC_106 | 21858 | 23219 | mnmE | 0.0 | central tRNA-modifying GTPase | 82.24 | 99.56 | ABP90420 |
| DGNHLIAC_114 | 48495 | 46603 | PepO | 0.0 | endopeptidase | 80.19 | 100.00 | ABF32980 |
| DGNHLIAC_107 | 81863 | 82753 | bglB | 2.19e-179 | putative phospho--glucosidase | 88.55 | 99.66 | AAK33487 |
| DGNHLIAC_57 | 43863 | 44801 | SP_0676 | 2.36e-169 | transcription facot | 81.47 | 97.20 | AAK74821 |
| DGNHLIAC_87 | 27346 | 26489 | metF | 1.41e-165 | methionine biosynthesis enzymes | 85.66 | 99.31 | AAK74739 |
| DGNHLIAC_111 | 3617 | 4321 | covR | 3.16e-133 | responder protein | 85.53 | 100.00 | AAK71319 |
| DGNHLIAC_48 | 24416 | 23745 | rr01 | 7.61e-125 | response regulator | 83.48 | 99.56 | CAB54566 |
| DGNHLIAC_111 | 3617 | 4321 | walR | 2.97e-123 | DNA-binding response regulator | 81.70 | 100.00 | ANC99504 |
| DGNHLIAC_3 | 16139 | 16825 | CovR | 1.30e-119 | serves to repress GAS virulence factor-encoding genes | 80.79 | 100.00 | ACE75886 |
| DGNHLIAC_87 | 20659 | 19991 | CiaR | 3.87e-119 | two-component response regulator | 84.31 | 99.55 | AAK74935 |
| DGNHLIAC_87 | 20659 | 19988 | ciaR | 3.81e-117 | two component system response regulator | 82.14 | 99.12 | AIK75708 |
| DGNHLIAC_45 | 13887 | 14261 | SpxA2 | 8.91e-72 | transcriptional regulator | 91.20 | 94.70 | ERL21461 |
| DGNHLIAC_106 | 10498 | 10097 | SpxA1 | 4.71e-68 | transcriptional regulator | 80.60 | 100.00 | ERL19273 |
| DGNHLIAC_46 | 13686 | 13973 | spr0479 | 2.98e-49 | essential gene | 86.46 | 98.97 | AAK99283 |
| DGNHLIAC_69 | 5689 | 5435 | spr1327 | 1.23e-45 | essential gene | 94.12 | 100.00 | AAL00131 |
| DGNHLIAC_2 | 17597 | 17334 | spr0175 | 7.64e-43 | pathogenitcity related | 84.09 | 100.00 | AAK98979 |
| DGNHLIAC_2 | 16770 | 16504 | spr0177 | 2.43e-34 | essential gene | 84.27 | 88.12 | AAK98981 |
| DGNHLIAC_115 | 6752 | 7252 | RopE (M5005_Spy_1611) | 1.84e-76 | probable DNA-directed RNA polymerase subunit delta | 81.44 | 87.43 | AAK34603 |
| DGNHLIAC_113 | 15570 | 13273 | PFL (B9H01_RS01125) | 0.0 | formate C-acetyltransferase | 82.94 | 98.08 | MYN69560 |
| DGNHLIAC_114 | 34025 | 33006 | ilvC (SPD_0406) | 0.0 | ketol-acid reductoisomerase (NADP(+)) | 96.47 | 100.00 | ABJ55451 |
BLASTX v2.16.0 (Database: PHI base v4.16, May. 2024 release)
Plasmid
PlasmidFinder
| Query ID | Begin | End | Plasmid | Query / Template | Identity | Accession no. |
|---|---|---|---|---|---|---|
| No hit found | ||||||
PlasmidFinder v 2.1.6 (Database: plasmidfinder_db v 2.2.0 , Nov. 2024 release)
PlasmidHunter
| Query ID | Prediction | Chromosome | Plasmid |
|---|---|---|---|
| DGNHLIAC_1 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_2 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_3 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_5 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_6 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_7 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_8 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_10 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_11 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_12 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_13 | 1.0 | 0.0 | 1.0 |
| DGNHLIAC_14 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_17 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_21 | 1.0 | 0.0 | 1.0 |
| DGNHLIAC_22 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_26 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_30 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_32 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_34 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_35 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_36 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_37 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_38 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_39 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_40 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_41 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_42 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_43 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_44 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_45 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_46 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_47 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_48 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_49 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_50 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_51 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_52 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_53 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_54 | 1.0 | 0.0 | 1.0 |
| DGNHLIAC_55 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_56 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_57 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_58 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_59 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_60 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_61 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_62 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_63 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_64 | 1.0 | 0.0 | 1.0 |
| DGNHLIAC_65 | 1.0 | 0.0 | 1.0 |
| DGNHLIAC_66 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_67 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_68 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_69 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_71 | 1.0 | 0.0 | 1.0 |
| DGNHLIAC_76 | 1.0 | 0.0 | 1.0 |
| DGNHLIAC_77 | 1.0 | 0.0 | 1.0 |
| DGNHLIAC_78 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_82 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_85 | 1.0 | 0.0 | 1.0 |
| DGNHLIAC_87 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_88 | 1.0 | 0.0 | 1.0 |
| DGNHLIAC_89 | 1.0 | 0.0 | 1.0 |
| DGNHLIAC_97 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_103 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_104 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_106 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_107 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_108 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_109 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_110 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_111 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_112 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_113 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_114 | 0.0 | 1.0 | 0.0 |
| DGNHLIAC_115 | 0.0 | 1.0 | 0.0 |
PlasmidHunter v 1.4.5 (Database: May. 2024 release)
Prophage
Phigaro
| Query ID | Begin | End | Transposable | Taxonomy | pVOGs |
|---|---|---|---|---|---|
| No hit found | |||||
Phigaro v2.4.0 (Database: Jan. 2024 release)