Probiotic potential risk score
| ARGs | VFs | PGs | PPRS |
|---|---|---|---|
| 0 | 27 | 32 | 41.87 |
PPRS is classified as low-risk (≤4), medium-risk (4-6), and high-risk (≥6).
Antibiotic resistance genes
Comprehensive Antibiotic Resistance Database (CARD)
| Query ID | Begin | End | ARO name | ARO accession | CARD name | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
RGI v6.0.3 (Database: CARD Variants v4.0.2, Nov. 2023 release)
ResFinder
| Query ID | Begin | End | Resistance gene | Phenotype | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|
| No hit found | |||||||
ResFinder v4.6.0 (Database: resfinder_db, Aug. 2024 release)
AMRFinderPlus
| Query ID | Begin | End | Gene symbol | Sequence name | Method | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
AMRFinderPlus v4.0.3 (Database: Oct. 2024 release)
Virulence factors
Virulence Factor Database (VFDB)
| Query ID | qstart | qend | Gene name | e-value | VF name | VF category | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|---|
| LANLPBCD_108 | 9589 | 10458 | rfbA | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011681286 |
| LANLPBCD_108 | 8996 | 9589 | STER_RS06030 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011226149 |
| LANLPBCD_29 | 86143 | 87402 | STER_RS07100 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011681445 |
| LANLPBCD_29 | 90424 | 91200 | STER_RS07075 | 0.0 | Capsule | Immune modulation | 99.87 | 100.00 | WP_011681440 |
| LANLPBCD_108 | 8996 | 9589 | STR_RS05880 | 0.0 | Capsule | Immune modulation | 99.83 | 100.00 | WP_011226149 |
| LANLPBCD_29 | 91319 | 92467 | STER_RS07070 | 0.0 | Capsule | Immune modulation | 99.74 | 100.00 | WP_011681439 |
| LANLPBCD_108 | 8996 | 9589 | STU_RS15260 | 0.0 | Capsule | Immune modulation | 99.66 | 100.00 | WP_011226149 |
| LANLPBCD_29 | 87399 | 88375 | STER_RS07095 | 0.0 | Capsule | Immune modulation | 99.59 | 99.90 | WP_011681444 |
| LANLPBCD_29 | 92464 | 93405 | STER_RS07065 | 0.0 | Capsule | Immune modulation | 99.58 | 100.00 | WP_011681438 |
| LANLPBCD_37 | 21996 | 22835 | cbpD | 0.0 | Autolysin | Exoenzyme | 99.52 | 100.00 | WP_011226733 |
| LANLPBCD_35 | 65510 | 67168 | fbp54 | 0.0 | FBPs | Adherence | 99.52 | 100.00 | WP_011227179 |
| LANLPBCD_29 | 93405 | 94211 | STER_RS07060 | 0.0 | Capsule | Immune modulation | 99.50 | 100.00 | WP_011681437 |
| LANLPBCD_29 | 91319 | 92467 | STR_RS06910 | 0.0 | Capsule | Immune modulation | 99.48 | 100.00 | WP_011227431 |
| LANLPBCD_29 | 92464 | 93405 | STR_RS06905 | 0.0 | Capsule | Immune modulation | 99.47 | 100.00 | WP_011227430 |
| LANLPBCD_29 | 96819 | 98564 | STER_RS07045 | 0.0 | Capsule | Immune modulation | 99.37 | 100.00 | WP_011681434 |
| LANLPBCD_29 | 89363 | 90078 | STER_RS07085 | 0.0 | Capsule | Immune modulation | 99.30 | 99.86 | WP_011681442 |
| LANLPBCD_29 | 88393 | 89361 | STER_RS07090 | 0.0 | Capsule | Immune modulation | 99.28 | 100.00 | WP_011681443 |
| LANLPBCD_29 | 93405 | 94211 | STR_RS06900 | 0.0 | Capsule | Immune modulation | 99.26 | 100.00 | WP_011227429 |
| LANLPBCD_108 | 44356 | 45117 | srtA | 0.0 | Sortase A | Exoenzyme | 99.08 | 100.00 | - |
| LANLPBCD_50 | 3387 | 4118 | STER_RS05315 | 0.0 | Capsule | Immune modulation | 98.50 | 100.00 | WP_011681176 |
| LANLPBCD_50 | 3387 | 4118 | STU_RS14645 | 0.0 | Capsule | Immune modulation | 98.50 | 100.00 | WP_011226048 |
| LANLPBCD_29 | 85173 | 86024 | rfbD | 0.0 | Capsule | Immune modulation | 98.36 | 100.00 | WP_014621820 |
| LANLPBCD_50 | 3387 | 4118 | STR_RS05260 | 0.0 | Capsule | Immune modulation | 98.36 | 100.00 | WP_011227248 |
| LANLPBCD_29 | 96819 | 98564 | STR_RS06885 | 0.0 | Capsule | Immune modulation | 98.05 | 100.00 | WP_011227426 |
| LANLPBCD_24 | 111 | 900 | cshA | 0.0 | Cell surface hydrophobicity proteins | Adherence | 97.98 | 99.75 | - |
| LANLPBCD_60 | 655 | 2070 | STER_RS05250 | 0.0 | Capsule | Immune modulation | 97.88 | 100.00 | WP_011681165 |
| LANLPBCD_50 | 4119 | 5579 | STER_RS05320 | 0.0 | Capsule | Immune modulation | 97.33 | 100.00 | WP_011681177 |
| LANLPBCD_50 | 1936 | 2676 | STER_RS05305 | 0.0 | Capsule | Immune modulation | 97.31 | 99.87 | WP_011681174 |
| LANLPBCD_50 | 1936 | 2676 | STU_RS14635 | 0.0 | Capsule | Immune modulation | 96.90 | 99.87 | WP_011226046 |
| LANLPBCD_50 | 2686 | 3378 | STU_RS14640 | 0.0 | Capsule | Immune modulation | 96.83 | 99.86 | WP_011226047 |
| LANLPBCD_50 | 1941 | 2676 | STR_RS05250 | 0.0 | Capsule | Immune modulation | 96.61 | 98.00 | WP_011227246 |
| LANLPBCD_50 | 2686 | 3378 | STR_RS05255 | 0.0 | Capsule | Immune modulation | 96.54 | 100.00 | WP_011227247 |
| LANLPBCD_50 | 4119 | 5579 | STU_RS14650 | 0.0 | Capsule | Immune modulation | 96.03 | 100.21 | WP_011226049 |
| LANLPBCD_50 | 4119 | 5579 | STR_RS05265 | 0.0 | Capsule | Immune modulation | 95.55 | 100.21 | WP_041827043 |
| LANLPBCD_50 | 514 | 1879 | STER_RS05300 | 0.0 | Capsule | Immune modulation | 95.46 | 99.85 | WP_011681173 |
| LANLPBCD_50 | 512 | 1879 | STU_RS14630 | 0.0 | Capsule | Immune modulation | 94.08 | 100.00 | WP_011226045 |
| LANLPBCD_50 | 2686 | 3378 | STER_RS05310 | 0.0 | Capsule | Immune modulation | 89.90 | 100.00 | WP_011681175 |
| LANLPBCD_31 | 25565 | 26868 | eno | 0.0 | Streptococcal enolase | Exoenzyme | 88.17 | 99.54 | WP_000022832 |
| LANLPBCD_111 | 297 | 1307 | plr/gapA | 0.0 | Streptococcal plasmin receptor/GAPDH | Adherence | 86.66 | 99.90 | WP_002986042 |
| LANLPBCD_29 | 94211 | 95434 | SGO_RS05025 | 0.0 | Capsule | Immune modulation | 84.92 | 99.92 | WP_012000441 |
| LANLPBCD_29 | 93405 | 94211 | SGO_RS05020 | 0.0 | Capsule | Immune modulation | 83.27 | 100.00 | WP_012000440 |
| LANLPBCD_68 | 2254 | 3537 | tig/ropA | 0.0 | Trigger factor | Stress survival | 80.73 | 99.77 | WP_000107753 |
| LANLPBCD_108 | 7521 | 8567 | rfbB | 0.0 | Capsule | Immune modulation | 80.61 | 100.00 | WP_009659423 |
| LANLPBCD_29 | 94211 | 94948 | STR_RS06895 | 0.0 | Capsule | Immune modulation | 96.61 | 61.35 | WP_011227428 |
| LANLPBCD_29 | 94211 | 94948 | STER_RS07055 | 0.0 | Capsule | Immune modulation | 96.34 | 61.35 | WP_011681436 |
BLASTN v2.16.0 (Database: VFDB, Dec. 2024 release)
VirulenceFinder
| Query ID | Begin | End | Database | Virulence factor | Protein function | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
VirulenceFinder v2.0. 4 (Database: virulencefinder_db, Feb . 2024 release)
Pathogenic genes
PHI-base
| Query ID | qstart | qend | Gene name | e-value | Function | Identity | Coverage | Gene ID |
|---|---|---|---|---|---|---|---|---|
| LANLPBCD_108 | 47804 | 48787 | ldh(Sp_1220) | 0.0 | L-lactate dehydrogenase | 94.51 | 100.00 | AAK75326 |
| LANLPBCD_26 | 6733 | 7806 | MntE | 0.0 | manganese homeostasis | 94.41 | 99.72 | ABF32167 |
| LANLPBCD_109 | 66886 | 69189 | pfl2(Sp_0459) | 0.0 | formate acetyltransferase | 93.10 | 99.22 | AAK74619 |
| LANLPBCD_31 | 110551 | 109583 | spr0084 | 0.0 | pathogenitcity related | 92.26 | 98.48 | AAK98888 |
| LANLPBCD_53 | 13141 | 11660 | SPD_0310 | 0.0 | UPF0371 protein SPD_0310 | 92.11 | 100.00 | ABJ54480 |
| LANLPBCD_34 | 27658 | 25412 | metE | 0.0 | methionine biosynthesis enzymes | 91.99 | 100.00 | AAK74738 |
| LANLPBCD_37 | 1984 | 986 | recA | 0.0 | DNA recombination and repair | 91.29 | 85.82 | AAL00560 |
| LANLPBCD_42 | 27 | 998 | prsA2 | 0.0 | ribose-phosphate pyrophosphokinase | 90.12 | 100.00 | ABF36968 |
| LANLPBCD_29 | 35848 | 36999 | potA | 0.0 | ABC transporter ATP-binding protein-spermidine/putrescine transport | 89.32 | 99.74 | AAL00050 |
| LANLPBCD_29 | 71999 | 73987 | uvrB | 0.0 | excinuclease ABC, B subunit | 88.84 | 100.00 | AE014259_2 |
| LANLPBCD_108 | 31606 | 29876 | ptsI | 0.0 | phosphoenolpyruvate-protein phosphotransferase | 88.22 | 100.00 | AAK34199 |
| LANLPBCD_41 | 26966 | 25488 | IMPDH | 0.0 | inosine-5'-monophosphate dehydrogenase | 87.63 | 100.00 | ADE32434 |
| LANLPBCD_31 | 26868 | 25567 | Eno | 0.0 | enolase | 86.21 | 99.77 | ABP90468 |
| LANLPBCD_41 | 12231 | 10339 | gidA | 0.0 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme | 85.74 | 98.90 | ABP91129 |
| LANLPBCD_34 | 22487 | 24196 | PGM | 0.0 | phosphoglucomutase | 83.89 | 99.65 | ACH87041 |
| LANLPBCD_23 | 55057 | 54047 | pdh | 0.0 | pyruvate dehydrogenase | 82.79 | 99.70 | ABP91006 |
| LANLPBCD_35 | 30294 | 31655 | mnmE | 0.0 | central tRNA-modifying GTPase | 82.02 | 99.56 | ABP90420 |
| LANLPBCD_23 | 4742 | 6634 | PepO | 0.0 | endopeptidase | 80.03 | 100.00 | ABF32980 |
| LANLPBCD_31 | 41307 | 40417 | bglB | 8.41e-180 | putative phospho--glucosidase | 88.89 | 99.66 | AAK33487 |
| LANLPBCD_119 | 11809 | 10874 | SP_0676 | 2.02e-169 | transcription facot | 81.73 | 96.89 | AAK74821 |
| LANLPBCD_34 | 25220 | 24363 | metF | 3.56e-166 | methionine biosynthesis enzymes | 86.36 | 99.31 | AAK74739 |
| LANLPBCD_49 | 19530 | 18826 | covR | 5.54e-131 | responder protein | 84.68 | 100.00 | AAK71319 |
| LANLPBCD_53 | 32115 | 32786 | rr01 | 9.58e-126 | response regulator | 83.93 | 99.56 | CAB54566 |
| LANLPBCD_34 | 18533 | 17865 | CiaR | 4.09e-122 | two-component response regulator | 85.65 | 99.55 | AAK74935 |
| LANLPBCD_49 | 19530 | 18826 | walR | 3.64e-121 | DNA-binding response regulator | 80.85 | 100.00 | ANC99504 |
| LANLPBCD_64 | 7721 | 7035 | CovR | 3.91e-120 | serves to repress GAS virulence factor-encoding genes | 81.22 | 100.00 | ACE75886 |
| LANLPBCD_34 | 18533 | 17862 | ciaR | 4.89e-120 | two component system response regulator | 83.48 | 99.12 | AIK75708 |
| LANLPBCD_37 | 710 | 336 | SpxA2 | 1.48e-71 | transcriptional regulator | 91.20 | 94.70 | ERL21461 |
| LANLPBCD_45 | 25495 | 25208 | spr0479 | 2.99e-49 | essential gene | 86.46 | 98.97 | AAK99283 |
| LANLPBCD_27 | 9888 | 9634 | spr1327 | 5.99e-46 | essential gene | 95.29 | 100.00 | AAL00131 |
| LANLPBCD_22 | 19824 | 19561 | spr0175 | 1.97e-42 | pathogenitcity related | 84.09 | 100.00 | AAK98979 |
| LANLPBCD_22 | 19021 | 18731 | spr0177 | 1.43e-37 | essential gene | 81.00 | 98.02 | AAK98981 |
| LANLPBCD_68 | 3695 | 4195 | RopE (M5005_Spy_1611) | 2.29e-77 | probable DNA-directed RNA polymerase subunit delta | 81.44 | 87.43 | AAK34603 |
| LANLPBCD_109 | 66886 | 69183 | PFL (B9H01_RS01125) | 0.0 | formate C-acetyltransferase | 83.07 | 98.08 | MYN69560 |
| LANLPBCD_23 | 19195 | 20214 | ilvC (SPD_0406) | 0.0 | ketol-acid reductoisomerase (NADP(+)) | 96.47 | 100.00 | ABJ55451 |
BLASTX v2.16.0 (Database: PHI base v4.16, May. 2024 release)
Plasmid
PlasmidFinder
| Query ID | Begin | End | Plasmid | Query / Template | Identity | Accession no. |
|---|---|---|---|---|---|---|
| No hit found | ||||||
PlasmidFinder v 2.1.6 (Database: plasmidfinder_db v 2.2.0 , Nov. 2024 release)
PlasmidHunter
| Query ID | Prediction | Chromosome | Plasmid |
|---|---|---|---|
| LANLPBCD_2 | 1.0 | 0.0 | 1.0 |
| LANLPBCD_5 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_6 | 1.0 | 0.0 | 1.0 |
| LANLPBCD_9 | 1.0 | 0.0 | 1.0 |
| LANLPBCD_10 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_11 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_12 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_13 | 1.0 | 0.0 | 1.0 |
| LANLPBCD_22 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_23 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_24 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_25 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_26 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_27 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_28 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_29 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_30 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_31 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_32 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_33 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_34 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_35 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_36 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_37 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_38 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_39 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_40 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_41 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_42 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_43 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_44 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_45 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_46 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_49 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_50 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_51 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_52 | 1.0 | 0.0 | 1.0 |
| LANLPBCD_53 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_54 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_55 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_56 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_58 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_59 | 1.0 | 0.0 | 1.0 |
| LANLPBCD_60 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_61 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_62 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_63 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_64 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_65 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_66 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_67 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_68 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_70 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_71 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_72 | 1.0 | 0.0 | 1.0 |
| LANLPBCD_73 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_75 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_81 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_86 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_87 | 1.0 | 0.0 | 1.0 |
| LANLPBCD_90 | 1.0 | 0.0 | 1.0 |
| LANLPBCD_97 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_98 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_105 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_108 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_109 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_110 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_111 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_112 | 1.0 | 0.0 | 1.0 |
| LANLPBCD_113 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_114 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_115 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_116 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_117 | 0.0 | 1.0 | 0.0 |
| LANLPBCD_119 | 0.0 | 1.0 | 0.0 |
PlasmidHunter v 1.4.5 (Database: May. 2024 release)
Prophage
Phigaro
| Query ID | Begin | End | Transposable | Taxonomy | pVOGs |
|---|---|---|---|---|---|
| No hit found | |||||
Phigaro v2.4.0 (Database: Jan. 2024 release)