Probiotic potential risk score
| ARGs | VFs | PGs | PPRS |
|---|---|---|---|
| 0 | 27 | 29 | 39.62 |
PPRS is classified as low-risk (≤4), medium-risk (4-6), and high-risk (≥6).
Antibiotic resistance genes
Comprehensive Antibiotic Resistance Database (CARD)
| Query ID | Begin | End | ARO name | ARO accession | CARD name | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
RGI v6.0.3 (Database: CARD Variants v4.0.2, Nov. 2023 release)
ResFinder
| Query ID | Begin | End | Resistance gene | Phenotype | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|
| No hit found | |||||||
ResFinder v4.6.0 (Database: resfinder_db, Aug. 2024 release)
AMRFinderPlus
| Query ID | Begin | End | Gene symbol | Sequence name | Method | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
AMRFinderPlus v4.0.3 (Database: Oct. 2024 release)
Virulence factors
Virulence Factor Database (VFDB)
| Query ID | qstart | qend | Gene name | e-value | VF name | VF category | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|---|
| JPCKNAAK_1 | 1085929 | 1086522 | STER_RS06030 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011226149 |
| JPCKNAAK_1 | 1303856 | 1304572 | STER_RS07085 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011681442 |
| JPCKNAAK_1 | 1304573 | 1305541 | STER_RS07090 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011681443 |
| JPCKNAAK_1 | 1296803 | 1298503 | STER_RS07050 | 0.0 | Capsule | Immune modulation | 99.94 | 100.00 | WP_041827753 |
| JPCKNAAK_1 | 1306532 | 1307791 | STER_RS07100 | 0.0 | Capsule | Immune modulation | 99.92 | 100.00 | WP_011681445 |
| JPCKNAAK_1 | 1301467 | 1302615 | STER_RS07070 | 0.0 | Capsule | Immune modulation | 99.91 | 100.00 | WP_011681439 |
| JPCKNAAK_1 | 1086522 | 1087391 | rfbA | 0.0 | Capsule | Immune modulation | 99.89 | 100.00 | WP_011681286 |
| JPCKNAAK_1 | 1300529 | 1301470 | STER_RS07065 | 0.0 | Capsule | Immune modulation | 99.89 | 100.00 | WP_011681438 |
| JPCKNAAK_1 | 1302734 | 1303510 | STER_RS07075 | 0.0 | Capsule | Immune modulation | 99.87 | 100.00 | WP_011681440 |
| JPCKNAAK_1 | 1295056 | 1296801 | STER_RS07045 | 0.0 | Capsule | Immune modulation | 99.83 | 100.00 | WP_011681434 |
| JPCKNAAK_1 | 1298521 | 1299723 | STER_RS07055 | 0.0 | Capsule | Immune modulation | 99.83 | 100.00 | WP_011681436 |
| JPCKNAAK_1 | 1085929 | 1086522 | STR_RS05880 | 0.0 | Capsule | Immune modulation | 99.83 | 100.00 | WP_011226149 |
| JPCKNAAK_1 | 1296803 | 1298503 | STR_RS06890 | 0.0 | Capsule | Immune modulation | 99.77 | 100.00 | WP_041827077 |
| JPCKNAAK_1 | 854360 | 856018 | fbp54 | 0.0 | FBPs | Adherence | 99.70 | 100.00 | WP_011227179 |
| JPCKNAAK_1 | 1085929 | 1086522 | STU_RS15260 | 0.0 | Capsule | Immune modulation | 99.66 | 100.00 | WP_011226149 |
| JPCKNAAK_1 | 1299723 | 1300529 | STER_RS07060 | 0.0 | Capsule | Immune modulation | 99.63 | 100.00 | WP_011681437 |
| JPCKNAAK_1 | 1305559 | 1306535 | STER_RS07095 | 0.0 | Capsule | Immune modulation | 99.59 | 99.90 | WP_011681444 |
| JPCKNAAK_1 | 1298521 | 1299723 | STR_RS06895 | 0.0 | Capsule | Immune modulation | 99.58 | 100.00 | WP_011227428 |
| JPCKNAAK_1 | 43680 | 44519 | cbpD | 0.0 | Autolysin | Exoenzyme | 99.52 | 100.00 | WP_011226733 |
| JPCKNAAK_1 | 1300529 | 1301470 | STR_RS06905 | 0.0 | Capsule | Immune modulation | 99.36 | 100.00 | WP_011227430 |
| JPCKNAAK_1 | 1301467 | 1302615 | STR_RS06910 | 0.0 | Capsule | Immune modulation | 99.30 | 100.00 | WP_011227431 |
| JPCKNAAK_1 | 1299723 | 1300529 | STR_RS06900 | 0.0 | Capsule | Immune modulation | 99.13 | 100.00 | WP_011227429 |
| JPCKNAAK_1 | 962867 | 963607 | STER_RS05305 | 0.0 | Capsule | Immune modulation | 98.78 | 100.00 | WP_011681174 |
| JPCKNAAK_1 | 1031024 | 1031814 | cshA | 0.0 | Cell surface hydrophobicity proteins | Adherence | 98.74 | 100.00 | - |
| JPCKNAAK_1 | 962872 | 963607 | STR_RS05250 | 0.0 | Capsule | Immune modulation | 98.23 | 98.13 | WP_011227246 |
| JPCKNAAK_1 | 1295056 | 1296801 | STR_RS06885 | 0.0 | Capsule | Immune modulation | 98.17 | 100.00 | WP_011227426 |
| JPCKNAAK_1 | 962867 | 963607 | STU_RS14635 | 0.0 | Capsule | Immune modulation | 98.11 | 100.00 | WP_011226046 |
| JPCKNAAK_1 | 963617 | 964309 | STU_RS14640 | 0.0 | Capsule | Immune modulation | 97.69 | 100.00 | WP_011226047 |
| JPCKNAAK_1 | 965050 | 966510 | STER_RS05320 | 0.0 | Capsule | Immune modulation | 97.67 | 100.00 | WP_011681177 |
| JPCKNAAK_1 | 1122715 | 1123476 | srtA | 0.0 | Sortase A | Exoenzyme | 97.64 | 100.00 | - |
| JPCKNAAK_1 | 964318 | 965049 | STU_RS14645 | 0.0 | Capsule | Immune modulation | 97.54 | 100.00 | WP_011226048 |
| JPCKNAAK_1 | 1307910 | 1308761 | rfbD | 0.0 | Capsule | Immune modulation | 97.42 | 100.00 | WP_014621820 |
| JPCKNAAK_1 | 963617 | 964309 | STR_RS05255 | 0.0 | Capsule | Immune modulation | 97.40 | 100.00 | WP_011227247 |
| JPCKNAAK_1 | 964318 | 965049 | STR_RS05260 | 0.0 | Capsule | Immune modulation | 97.40 | 100.00 | WP_011227248 |
| JPCKNAAK_1 | 964318 | 965049 | STER_RS05315 | 0.0 | Capsule | Immune modulation | 97.27 | 100.00 | WP_011681176 |
| JPCKNAAK_1 | 965050 | 966510 | STU_RS14650 | 0.0 | Capsule | Immune modulation | 96.51 | 100.21 | WP_011226049 |
| JPCKNAAK_1 | 965050 | 966510 | STR_RS05265 | 0.0 | Capsule | Immune modulation | 95.69 | 100.21 | WP_041827043 |
| JPCKNAAK_1 | 961444 | 962809 | STER_RS05300 | 0.0 | Capsule | Immune modulation | 95.24 | 99.85 | WP_011681173 |
| JPCKNAAK_1 | 961442 | 962809 | STU_RS14630 | 0.0 | Capsule | Immune modulation | 94.96 | 100.00 | WP_011226045 |
| JPCKNAAK_1 | 963617 | 964309 | STER_RS05310 | 0.0 | Capsule | Immune modulation | 91.05 | 100.00 | WP_011681175 |
| JPCKNAAK_1 | 597749 | 599052 | eno | 0.0 | Streptococcal enolase | Exoenzyme | 88.10 | 99.46 | WP_000022832 |
| JPCKNAAK_1 | 1595456 | 1596466 | plr/gapA | 0.0 | Streptococcal plasmin receptor/GAPDH | Adherence | 86.54 | 99.41 | WP_002986042 |
| JPCKNAAK_1 | 1299723 | 1300529 | SGO_RS05020 | 0.0 | Capsule | Immune modulation | 83.27 | 100.00 | WP_012000440 |
| JPCKNAAK_1 | 150169 | 151452 | tig/ropA | 0.0 | Trigger factor | Stress survival | 80.65 | 99.77 | WP_000107753 |
| JPCKNAAK_1 | 1084454 | 1085500 | rfbB | 0.0 | Capsule | Immune modulation | 80.61 | 100.00 | WP_009659423 |
| JPCKNAAK_1 | 1298986 | 1299723 | SGO_RS05025 | 0.0 | Capsule | Immune modulation | 84.96 | 60.29 | WP_012000441 |
BLASTN v2.16.0 (Database: VFDB, Dec. 2024 release)
VirulenceFinder
| Query ID | Begin | End | Database | Virulence factor | Protein function | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
VirulenceFinder v2.0. 4 (Database: virulencefinder_db, Feb . 2024 release)
Pathogenic genes
PHI-base
| Query ID | qstart | qend | Gene name | e-value | Function | Identity | Coverage | Gene ID |
|---|---|---|---|---|---|---|---|---|
| JPCKNAAK_1 | 1126163 | 1127146 | ldh(Sp_1220) | 0.0 | L-lactate dehydrogenase | 94.51 | 100.00 | AAK75326 |
| JPCKNAAK_1 | 699457 | 700530 | MntE | 0.0 | manganese homeostasis | 94.41 | 99.72 | ABF32167 |
| JPCKNAAK_1 | 1472222 | 1474525 | pfl2(Sp_0459) | 0.0 | formate acetyltransferase | 92.97 | 99.22 | AAK74619 |
| JPCKNAAK_1 | 514105 | 515073 | spr0084 | 0.0 | pathogenitcity related | 92.57 | 98.48 | AAK98888 |
| JPCKNAAK_1 | 1199412 | 1200893 | SPD_0310 | 0.0 | UPF0371 protein SPD_0310 | 92.31 | 100.00 | ABJ54480 |
| JPCKNAAK_1 | 719982 | 722228 | metE | 0.0 | methionine biosynthesis enzymes | 91.99 | 100.00 | AAK74738 |
| JPCKNAAK_1 | 63311 | 64309 | recA | 0.0 | DNA recombination and repair | 91.29 | 85.82 | AAL00560 |
| JPCKNAAK_1 | 27198 | 28169 | prsA2 | 0.0 | ribose-phosphate pyrophosphokinase | 90.12 | 100.00 | ABF36968 |
| JPCKNAAK_1 | 1358215 | 1357064 | potA | 0.0 | ABC transporter ATP-binding protein-spermidine/putrescine transport | 89.06 | 99.74 | AAL00050 |
| JPCKNAAK_1 | 1321802 | 1319814 | uvrB | 0.0 | excinuclease ABC, B subunit | 88.84 | 100.00 | AE014259_2 |
| JPCKNAAK_1 | 1109965 | 1108235 | ptsI | 0.0 | phosphoenolpyruvate-protein phosphotransferase | 87.69 | 100.00 | AAK34199 |
| JPCKNAAK_1 | 1783036 | 1781558 | IMPDH | 0.0 | inosine-5'-monophosphate dehydrogenase | 87.63 | 100.00 | ADE32434 |
| JPCKNAAK_1 | 597749 | 599050 | Eno | 0.0 | enolase | 86.21 | 99.77 | ABP90468 |
| JPCKNAAK_1 | 1767847 | 1765955 | gidA | 0.0 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme | 86.05 | 98.90 | ABP91129 |
| JPCKNAAK_1 | 725153 | 723444 | PGM | 0.0 | phosphoglucomutase | 84.06 | 99.65 | ACH87041 |
| JPCKNAAK_1 | 1638593 | 1639603 | pdh | 0.0 | pyruvate dehydrogenase | 83.09 | 99.70 | ABP91006 |
| JPCKNAAK_1 | 882497 | 881136 | mnmE | 0.0 | central tRNA-modifying GTPase | 82.24 | 99.56 | ABP90420 |
| JPCKNAAK_1 | 1688926 | 1687034 | PepO | 0.0 | endopeptidase | 80.19 | 100.00 | ABF32980 |
| JPCKNAAK_1 | 583313 | 584203 | bglB | 1.29e-178 | putative phospho--glucosidase | 88.89 | 99.66 | AAK33487 |
| JPCKNAAK_1 | 796212 | 795274 | SP_0676 | 4.44e-167 | transcription facot | 81.15 | 97.20 | AAK74821 |
| JPCKNAAK_1 | 722420 | 723277 | metF | 1.48e-164 | methionine biosynthesis enzymes | 86.36 | 99.31 | AAK74739 |
| JPCKNAAK_1 | 1003346 | 1002642 | covR | 4.24e-131 | responder protein | 85.53 | 100.00 | AAK71319 |
| JPCKNAAK_1 | 1180440 | 1179769 | rr01 | 2.85e-125 | response regulator | 84.38 | 99.56 | CAB54566 |
| JPCKNAAK_1 | 1003346 | 1002642 | walR | 1.79e-121 | DNA-binding response regulator | 82.13 | 100.00 | ANC99504 |
| JPCKNAAK_1 | 295606 | 296292 | CovR | 9.74e-118 | serves to repress GAS virulence factor-encoding genes | 80.79 | 100.00 | ACE75886 |
| JPCKNAAK_1 | 729107 | 729775 | CiaR | 1.96e-117 | two-component response regulator | 84.31 | 99.55 | AAK74935 |
| JPCKNAAK_1 | 729107 | 729778 | ciaR | 1.93e-115 | two component system response regulator | 82.14 | 99.12 | AIK75708 |
| JPCKNAAK_1 | 64585 | 64959 | SpxA2 | 1.12e-69 | transcriptional regulator | 91.20 | 94.70 | ERL21461 |
| JPCKNAAK_1 | 893860 | 894261 | SpxA1 | 3.64e-66 | transcriptional regulator | 80.60 | 100.00 | ERL19273 |
| JPCKNAAK_1 | 151610 | 152110 | RopE (M5005_Spy_1611) | 4.76e-75 | probable DNA-directed RNA polymerase subunit delta | 81.44 | 87.43 | AAK34603 |
| JPCKNAAK_1 | 1472222 | 1474519 | PFL (B9H01_RS01125) | 0.0 | formate C-acetyltransferase | 82.94 | 98.08 | MYN69560 |
| JPCKNAAK_1 | 1674457 | 1673438 | ilvC (SPD_0406) | 0.0 | ketol-acid reductoisomerase (NADP(+)) | 96.47 | 100.00 | ABJ55451 |
BLASTX v2.16.0 (Database: PHI base v4.16, May. 2024 release)
Plasmid
PlasmidFinder
| Query ID | Begin | End | Plasmid | Query / Template | Identity | Accession no. |
|---|---|---|---|---|---|---|
| No hit found | ||||||
PlasmidFinder v 2.1.6 (Database: plasmidfinder_db v 2.2.0 , Nov. 2024 release)
PlasmidHunter
| Query ID | Prediction | Chromosome | Plasmid |
|---|---|---|---|
| JPCKNAAK_1 | 0.0 | 1.0 | 0.0 |
PlasmidHunter v 1.4.5 (Database: May. 2024 release)
Prophage
Phigaro
| Query ID | Begin | End | Transposable | Taxonomy | pVOGs |
|---|---|---|---|---|---|
| No hit found | |||||
Phigaro v2.4.0 (Database: Jan. 2024 release)