Probiotic potential risk score
| ARGs | VFs | PGs | PPRS |
|---|---|---|---|
| 0 | 23 | 32 | 39.41 |
PPRS is classified as low-risk (≤4), medium-risk (4-6), and high-risk (≥6).
Antibiotic resistance genes
Comprehensive Antibiotic Resistance Database (CARD)
| Query ID | Begin | End | ARO name | ARO accession | CARD name | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
RGI v6.0.3 (Database: CARD Variants v4.0.2, Nov. 2023 release)
ResFinder
| Query ID | Begin | End | Resistance gene | Phenotype | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|
| No hit found | |||||||
ResFinder v4.6.0 (Database: resfinder_db, Aug. 2024 release)
AMRFinderPlus
| Query ID | Begin | End | Gene symbol | Sequence name | Method | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
AMRFinderPlus v4.0.3 (Database: Oct. 2024 release)
Virulence factors
Virulence Factor Database (VFDB)
| Query ID | qstart | qend | Gene name | e-value | VF name | VF category | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|---|
| PAONAMNP_2 | 59435 | 60304 | rfbA | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011681286 |
| PAONAMNP_2 | 60304 | 60897 | STER_RS06030 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011226149 |
| PAONAMNP_4 | 89847 | 90656 | STU_RS16245 | 0.0 | Capsule | Immune modulation | 99.88 | 100.00 | WP_002948020 |
| PAONAMNP_2 | 180413 | 181873 | STER_RS05320 | 0.0 | Capsule | Immune modulation | 99.86 | 100.00 | WP_011681177 |
| PAONAMNP_2 | 60304 | 60897 | STR_RS05880 | 0.0 | Capsule | Immune modulation | 99.83 | 100.00 | WP_011226149 |
| PAONAMNP_4 | 88907 | 89863 | STU_RS16250 | 0.0 | Capsule | Immune modulation | 99.79 | 100.00 | WP_011226328 |
| PAONAMNP_4 | 87762 | 88910 | STU_RS16255 | 0.0 | Capsule | Immune modulation | 99.74 | 100.00 | WP_041828290 |
| PAONAMNP_2 | 60304 | 60897 | STU_RS15260 | 0.0 | Capsule | Immune modulation | 99.66 | 100.00 | WP_011226149 |
| PAONAMNP_25 | 990 | 2133 | cshA | 0.0 | Cell surface hydrophobicity proteins | Adherence | 99.65 | 100.00 | - |
| PAONAMNP_6 | 13366 | 15024 | fbp54 | 0.0 | FBPs | Adherence | 99.64 | 100.00 | WP_011227179 |
| PAONAMNP_11 | 20659 | 21498 | cbpD | 0.0 | Autolysin | Exoenzyme | 99.52 | 100.00 | WP_011226733 |
| PAONAMNP_4 | 90656 | 91861 | STU_RS16240 | 0.0 | Capsule | Immune modulation | 99.50 | 100.00 | WP_011226326 |
| PAONAMNP_4 | 92933 | 94717 | STU_RS16230 | 0.0 | Capsule | Immune modulation | 99.44 | 100.00 | WP_011226325 |
| PAONAMNP_4 | 91881 | 92936 | STU_RS16235 | 0.0 | Capsule | Immune modulation | 99.34 | 100.00 | WP_002948022 |
| PAONAMNP_2 | 181874 | 182605 | STER_RS05315 | 0.0 | Capsule | Immune modulation | 99.32 | 100.00 | WP_011681176 |
| PAONAMNP_2 | 183316 | 184056 | STER_RS05305 | 0.0 | Capsule | Immune modulation | 98.52 | 100.00 | WP_011681174 |
| PAONAMNP_2 | 183316 | 184056 | STU_RS14635 | 0.0 | Capsule | Immune modulation | 98.38 | 100.00 | WP_011226046 |
| PAONAMNP_2 | 181874 | 182605 | STR_RS05260 | 0.0 | Capsule | Immune modulation | 98.36 | 100.00 | WP_011227248 |
| PAONAMNP_2 | 181874 | 182605 | STU_RS14645 | 0.0 | Capsule | Immune modulation | 98.22 | 100.00 | WP_011226048 |
| PAONAMNP_2 | 24773 | 25534 | srtA | 0.0 | Sortase A | Exoenzyme | 98.03 | 100.00 | - |
| PAONAMNP_2 | 183316 | 184051 | STR_RS05250 | 0.0 | Capsule | Immune modulation | 97.83 | 98.13 | WP_011227246 |
| PAONAMNP_2 | 180413 | 181873 | STU_RS14650 | 0.0 | Capsule | Immune modulation | 97.33 | 100.21 | WP_011226049 |
| PAONAMNP_2 | 182614 | 183306 | STU_RS14640 | 0.0 | Capsule | Immune modulation | 96.83 | 100.00 | WP_011226047 |
| PAONAMNP_2 | 180413 | 181873 | STR_RS05265 | 0.0 | Capsule | Immune modulation | 96.78 | 100.21 | WP_041827043 |
| PAONAMNP_4 | 83409 | 84260 | rfbD | 0.0 | Capsule | Immune modulation | 96.60 | 100.00 | WP_014621820 |
| PAONAMNP_2 | 184113 | 185480 | STU_RS14630 | 0.0 | Capsule | Immune modulation | 96.27 | 100.00 | WP_011226045 |
| PAONAMNP_2 | 182614 | 183306 | STR_RS05255 | 0.0 | Capsule | Immune modulation | 96.25 | 100.00 | WP_011227247 |
| PAONAMNP_2 | 184113 | 185478 | STER_RS05300 | 0.0 | Capsule | Immune modulation | 95.09 | 99.85 | WP_011681173 |
| PAONAMNP_2 | 182614 | 183306 | STER_RS05310 | 0.0 | Capsule | Immune modulation | 92.78 | 100.00 | WP_011681175 |
| PAONAMNP_4 | 85363 | 86637 | STU_RS16265 | 0.0 | Capsule | Immune modulation | 91.14 | 100.00 | WP_011226331 |
| PAONAMNP_1 | 135672 | 136975 | eno | 0.0 | Streptococcal enolase | Exoenzyme | 88.10 | 99.46 | WP_000022832 |
| PAONAMNP_20 | 1443 | 2453 | plr/gapA | 0.0 | Streptococcal plasmin receptor/GAPDH | Adherence | 87.56 | 99.80 | WP_002986042 |
| PAONAMNP_5 | 5001 | 6284 | tig/ropA | 0.0 | Trigger factor | Stress survival | 80.73 | 99.77 | WP_000107753 |
| PAONAMNP_2 | 61326 | 62372 | rfbB | 0.0 | Capsule | Immune modulation | 80.61 | 100.00 | WP_009659423 |
BLASTN v2.16.0 (Database: VFDB, Dec. 2024 release)
VirulenceFinder
| Query ID | Begin | End | Database | Virulence factor | Protein function | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
VirulenceFinder v2.0. 4 (Database: virulencefinder_db, Feb . 2024 release)
Pathogenic genes
PHI-base
| Query ID | qstart | qend | Gene name | e-value | Function | Identity | Coverage | Gene ID |
|---|---|---|---|---|---|---|---|---|
| PAONAMNP_2 | 22086 | 21103 | ldh(Sp_1220) | 0.0 | L-lactate dehydrogenase | 94.82 | 100.00 | AAK75326 |
| PAONAMNP_1 | 31761 | 30688 | MntE | 0.0 | manganese homeostasis | 94.41 | 99.72 | ABF32167 |
| PAONAMNP_3 | 89255 | 91558 | pfl2(Sp_0459) | 0.0 | formate acetyltransferase | 92.97 | 99.22 | AAK74619 |
| PAONAMNP_1 | 219209 | 218241 | spr0084 | 0.0 | pathogenitcity related | 92.88 | 98.48 | AAK98888 |
| PAONAMNP_8 | 69092 | 70573 | SPD_0310 | 0.0 | UPF0371 protein SPD_0310 | 92.11 | 100.00 | ABJ54480 |
| PAONAMNP_1 | 11237 | 8991 | metE | 0.0 | methionine biosynthesis enzymes | 91.99 | 100.00 | AAK74738 |
| PAONAMNP_11 | 1867 | 869 | recA | 0.0 | DNA recombination and repair | 91.29 | 85.82 | AAL00560 |
| PAONAMNP_11 | 37982 | 37011 | prsA2 | 0.0 | ribose-phosphate pyrophosphokinase | 90.12 | 100.00 | ABF36968 |
| PAONAMNP_4 | 32150 | 33301 | potA | 0.0 | ABC transporter ATP-binding protein-spermidine/putrescine transport | 89.32 | 99.74 | AAL00050 |
| PAONAMNP_4 | 68439 | 70427 | uvrB | 0.0 | excinuclease ABC, B subunit | 88.99 | 100.00 | AE014259_2 |
| PAONAMNP_2 | 38285 | 40015 | ptsI | 0.0 | phosphoenolpyruvate-protein phosphotransferase | 87.69 | 100.00 | AAK34199 |
| PAONAMNP_9 | 13769 | 15247 | IMPDH | 0.0 | inosine-5'-monophosphate dehydrogenase | 87.63 | 100.00 | ADE32434 |
| PAONAMNP_1 | 136975 | 135674 | Eno | 0.0 | enolase | 86.21 | 99.77 | ABP90468 |
| PAONAMNP_9 | 28502 | 30394 | gidA | 0.0 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme | 85.74 | 98.90 | ABP91129 |
| PAONAMNP_1 | 6066 | 7775 | PGM | 0.0 | phosphoglucomutase | 84.06 | 99.65 | ACH87041 |
| PAONAMNP_10 | 54713 | 53703 | pdh | 0.0 | pyruvate dehydrogenase | 83.09 | 99.70 | ABP91006 |
| PAONAMNP_6 | 41287 | 39926 | mnmE | 0.0 | central tRNA-modifying GTPase | 82.24 | 99.56 | ABP90420 |
| PAONAMNP_10 | 4398 | 6290 | PepO | 0.0 | endopeptidase | 80.19 | 100.00 | ABF32980 |
| PAONAMNP_1 | 151410 | 150520 | bglB | 6.55e-179 | putative phospho--glucosidase | 88.55 | 99.66 | AAK33487 |
| PAONAMNP_6 | 147148 | 148086 | SP_0676 | 2.01e-168 | transcription facot | 81.15 | 97.20 | AAK74821 |
| PAONAMNP_1 | 8799 | 7942 | metF | 1.91e-165 | methionine biosynthesis enzymes | 86.36 | 99.31 | AAK74739 |
| PAONAMNP_2 | 143623 | 144327 | covR | 4.70e-132 | responder protein | 85.53 | 100.00 | AAK71319 |
| PAONAMNP_8 | 31229 | 30558 | rr01 | 1.33e-125 | response regulator | 83.93 | 99.56 | CAB54566 |
| PAONAMNP_2 | 143623 | 144327 | walR | 1.98e-122 | DNA-binding response regulator | 82.13 | 100.00 | ANC99504 |
| PAONAMNP_1 | 2112 | 1444 | CiaR | 6.38e-121 | two-component response regulator | 85.20 | 99.55 | AAK74935 |
| PAONAMNP_5 | 158005 | 158691 | CovR | 8.99e-119 | serves to repress GAS virulence factor-encoding genes | 80.79 | 100.00 | ACE75886 |
| PAONAMNP_1 | 2112 | 1441 | ciaR | 9.34e-119 | two component system response regulator | 83.04 | 99.12 | AIK75708 |
| PAONAMNP_11 | 593 | 219 | SpxA2 | 2.55e-71 | transcriptional regulator | 91.20 | 94.70 | ERL21461 |
| PAONAMNP_12 | 25495 | 25208 | spr0479 | 2.99e-49 | essential gene | 86.46 | 98.97 | AAK99283 |
| PAONAMNP_13 | 10725 | 10979 | spr1327 | 4.97e-46 | essential gene | 95.29 | 100.00 | AAL00131 |
| PAONAMNP_9 | 62123 | 61860 | spr0175 | 2.99e-42 | pathogenitcity related | 84.09 | 100.00 | AAK98979 |
| PAONAMNP_9 | 61296 | 61030 | spr0177 | 6.54e-34 | essential gene | 84.27 | 88.12 | AAK98981 |
| PAONAMNP_5 | 6442 | 6942 | RopE (M5005_Spy_1611) | 4.40e-76 | probable DNA-directed RNA polymerase subunit delta | 81.44 | 87.43 | AAK34603 |
| PAONAMNP_3 | 89255 | 91552 | PFL (B9H01_RS01125) | 0.0 | formate C-acetyltransferase | 82.94 | 98.08 | MYN69560 |
| PAONAMNP_10 | 18855 | 19874 | ilvC (SPD_0406) | 0.0 | ketol-acid reductoisomerase (NADP(+)) | 96.47 | 100.00 | ABJ55451 |
BLASTX v2.16.0 (Database: PHI base v4.16, May. 2024 release)
Plasmid
PlasmidFinder
| Query ID | Begin | End | Plasmid | Query / Template | Identity | Accession no. |
|---|---|---|---|---|---|---|
| No hit found | ||||||
PlasmidFinder v 2.1.6 (Database: plasmidfinder_db v 2.2.0 , Nov. 2024 release)
PlasmidHunter
| Query ID | Prediction | Chromosome | Plasmid |
|---|---|---|---|
| PAONAMNP_1 | 0.0 | 1.0 | 0.0 |
| PAONAMNP_2 | 0.0 | 1.0 | 0.0 |
| PAONAMNP_3 | 0.0 | 1.0 | 0.0 |
| PAONAMNP_4 | 0.0 | 1.0 | 0.0 |
| PAONAMNP_5 | 0.0 | 1.0 | 0.0 |
| PAONAMNP_6 | 0.0 | 1.0 | 0.0 |
| PAONAMNP_7 | 0.0 | 1.0 | 0.0 |
| PAONAMNP_8 | 0.0 | 1.0 | 0.0 |
| PAONAMNP_9 | 0.0 | 1.0 | 0.0 |
| PAONAMNP_10 | 0.0 | 1.0 | 0.0 |
| PAONAMNP_11 | 0.0 | 1.0 | 0.0 |
| PAONAMNP_12 | 0.0 | 1.0 | 0.0 |
| PAONAMNP_13 | 0.0 | 1.0 | 0.0 |
| PAONAMNP_14 | 0.0 | 1.0 | 0.0 |
| PAONAMNP_15 | 0.0 | 1.0 | 0.0 |
| PAONAMNP_16 | 0.0 | 1.0 | 0.0 |
| PAONAMNP_17 | 0.0 | 1.0 | 0.0 |
| PAONAMNP_18 | 0.0 | 1.0 | 0.0 |
| PAONAMNP_19 | 0.0 | 1.0 | 0.0 |
| PAONAMNP_20 | 0.0 | 1.0 | 0.0 |
| PAONAMNP_21 | 0.0 | 1.0 | 0.0 |
| PAONAMNP_22 | 0.0 | 1.0 | 0.0 |
| PAONAMNP_23 | 1.0 | 0.0 | 1.0 |
| PAONAMNP_25 | 1.0 | 0.0 | 1.0 |
| PAONAMNP_26 | 1.0 | 0.0 | 1.0 |
| PAONAMNP_27 | 0.0 | 1.0 | 0.0 |
| PAONAMNP_28 | 1.0 | 0.0 | 1.0 |
| PAONAMNP_29 | 1.0 | 0.0 | 1.0 |
| PAONAMNP_30 | 1.0 | 0.0 | 1.0 |
| PAONAMNP_31 | 0.0 | 1.0 | 0.0 |
| PAONAMNP_32 | 0.0 | 1.0 | 0.0 |
| PAONAMNP_33 | 0.0 | 1.0 | 0.0 |
| PAONAMNP_34 | 1.0 | 0.0 | 1.0 |
| PAONAMNP_35 | 0.0 | 1.0 | 0.0 |
| PAONAMNP_36 | 0.0 | 1.0 | 0.0 |
PlasmidHunter v 1.4.5 (Database: May. 2024 release)
Prophage
Phigaro
| Query ID | Begin | End | Transposable | Taxonomy | pVOGs |
|---|---|---|---|---|---|
| No hit found | |||||
Phigaro v2.4.0 (Database: Jan. 2024 release)