Probiotic potential risk score
| ARGs | VFs | PGs | PPRS |
|---|---|---|---|
| 0 | 22 | 28 | 35.61 |
PPRS is classified as low-risk (≤4), medium-risk (4-6), and high-risk (≥6).
Antibiotic resistance genes
Comprehensive Antibiotic Resistance Database (CARD)
| Query ID | Begin | End | ARO name | ARO accession | CARD name | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
RGI v6.0.3 (Database: CARD Variants v4.0.2, Nov. 2023 release)
ResFinder
| Query ID | Begin | End | Resistance gene | Phenotype | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|
| No hit found | |||||||
ResFinder v4.6.0 (Database: resfinder_db, Aug. 2024 release)
AMRFinderPlus
| Query ID | Begin | End | Gene symbol | Sequence name | Method | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
AMRFinderPlus v4.0.3 (Database: Oct. 2024 release)
Virulence factors
Virulence Factor Database (VFDB)
| Query ID | qstart | qend | Gene name | e-value | VF name | VF category | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|---|
| IAPDHHHN_1 | 1127211 | 1128080 | rfbA | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011681286 |
| IAPDHHHN_1 | 1126618 | 1127211 | STER_RS06030 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011226149 |
| IAPDHHHN_1 | 1348104 | 1349072 | STER_RS07090 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011681443 |
| IAPDHHHN_1 | 1126618 | 1127211 | STR_RS05880 | 0.0 | Capsule | Immune modulation | 99.83 | 100.00 | WP_011226149 |
| IAPDHHHN_1 | 1126618 | 1127211 | STU_RS15260 | 0.0 | Capsule | Immune modulation | 99.66 | 100.00 | WP_011226149 |
| IAPDHHHN_1 | 918759 | 920417 | fbp54 | 0.0 | FBPs | Adherence | 99.58 | 100.00 | WP_011227179 |
| IAPDHHHN_1 | 43631 | 44470 | cbpD | 0.0 | Autolysin | Exoenzyme | 99.41 | 100.00 | WP_011226733 |
| IAPDHHHN_1 | 1349090 | 1350067 | STER_RS07095 | 0.0 | Capsule | Immune modulation | 99.39 | 100.00 | WP_011681444 |
| IAPDHHHN_1 | 811362 | 812093 | STR_RS05260 | 0.0 | Capsule | Immune modulation | 98.91 | 100.00 | WP_011227248 |
| IAPDHHHN_1 | 1161980 | 1162741 | srtA | 0.0 | Sortase A | Exoenzyme | 98.82 | 100.00 | - |
| IAPDHHHN_1 | 812804 | 813544 | STU_RS14635 | 0.0 | Capsule | Immune modulation | 98.52 | 100.00 | WP_011226046 |
| IAPDHHHN_1 | 821400 | 822677 | STR_RS05265 | 0.0 | Capsule | Immune modulation | 98.51 | 87.84 | WP_041827043 |
| IAPDHHHN_1 | 821400 | 822677 | STU_RS14650 | 0.0 | Capsule | Immune modulation | 98.51 | 87.84 | WP_011226049 |
| IAPDHHHN_1 | 811362 | 812093 | STER_RS05315 | 0.0 | Capsule | Immune modulation | 98.50 | 100.00 | WP_011681176 |
| IAPDHHHN_1 | 812804 | 813544 | STER_RS05305 | 0.0 | Capsule | Immune modulation | 98.38 | 100.00 | WP_011681174 |
| IAPDHHHN_1 | 1068965 | 1069758 | cshA | 0.0 | Cell surface hydrophobicity proteins | Adherence | 98.36 | 100.25 | - |
| IAPDHHHN_1 | 1347387 | 1348103 | STER_RS07085 | 0.0 | Capsule | Immune modulation | 98.19 | 100.00 | WP_011681442 |
| IAPDHHHN_1 | 812102 | 812794 | STR_RS05255 | 0.0 | Capsule | Immune modulation | 98.12 | 100.00 | WP_011227247 |
| IAPDHHHN_1 | 812102 | 812794 | STU_RS14640 | 0.0 | Capsule | Immune modulation | 98.12 | 100.00 | WP_011226047 |
| IAPDHHHN_1 | 812804 | 813539 | STR_RS05250 | 0.0 | Capsule | Immune modulation | 97.83 | 98.13 | WP_011227246 |
| IAPDHHHN_1 | 811362 | 812093 | STU_RS14645 | 0.0 | Capsule | Immune modulation | 97.68 | 100.00 | WP_011226048 |
| IAPDHHHN_1 | 821400 | 822677 | STER_RS05320 | 0.0 | Capsule | Immune modulation | 97.20 | 87.68 | WP_011681177 |
| IAPDHHHN_1 | 1351441 | 1352292 | rfbD | 0.0 | Capsule | Immune modulation | 97.07 | 100.00 | WP_014621820 |
| IAPDHHHN_1 | 1346271 | 1347041 | STER_RS07075 | 0.0 | Capsule | Immune modulation | 96.89 | 99.10 | WP_011681440 |
| IAPDHHHN_1 | 1350064 | 1351322 | STER_RS07100 | 0.0 | Capsule | Immune modulation | 96.51 | 99.92 | WP_011681445 |
| IAPDHHHN_1 | 813601 | 814968 | STU_RS14630 | 0.0 | Capsule | Immune modulation | 96.42 | 100.00 | WP_011226045 |
| IAPDHHHN_1 | 813601 | 814966 | STER_RS05300 | 0.0 | Capsule | Immune modulation | 94.14 | 99.85 | WP_011681173 |
| IAPDHHHN_1 | 812102 | 812794 | STER_RS05310 | 0.0 | Capsule | Immune modulation | 89.90 | 100.00 | WP_011681175 |
| IAPDHHHN_1 | 621344 | 622647 | eno | 0.0 | Streptococcal enolase | Exoenzyme | 88.10 | 99.46 | WP_000022832 |
| IAPDHHHN_1 | 1630622 | 1631632 | plr/gapA | 0.0 | Streptococcal plasmin receptor/GAPDH | Adherence | 87.46 | 99.80 | WP_002986042 |
| IAPDHHHN_1 | 159834 | 161117 | tig/ropA | 0.0 | Trigger factor | Stress survival | 80.73 | 99.77 | WP_000107753 |
| IAPDHHHN_1 | 1125143 | 1126189 | rfbB | 0.0 | Capsule | Immune modulation | 80.52 | 100.00 | WP_009659423 |
| IAPDHHHN_1 | 825061 | 825644 | SPD_RS01775 | 5.03e-150 | Capsule | Immune modulation | 83.42 | 96.20 | WP_001819836 |
BLASTN v2.16.0 (Database: VFDB, Dec. 2024 release)
VirulenceFinder
| Query ID | Begin | End | Database | Virulence factor | Protein function | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
VirulenceFinder v2.0. 4 (Database: virulencefinder_db, Feb . 2024 release)
Pathogenic genes
PHI-base
| Query ID | qstart | qend | Gene name | e-value | Function | Identity | Coverage | Gene ID |
|---|---|---|---|---|---|---|---|---|
| IAPDHHHN_1 | 1165428 | 1166411 | ldh(Sp_1220) | 0.0 | L-lactate dehydrogenase | 94.82 | 100.00 | AAK75326 |
| IAPDHHHN_1 | 731521 | 732594 | MntE | 0.0 | manganese homeostasis | 94.41 | 99.72 | ABF32167 |
| IAPDHHHN_1 | 537707 | 538675 | spr0084 | 0.0 | pathogenitcity related | 93.19 | 98.48 | AAK98888 |
| IAPDHHHN_1 | 1508921 | 1511224 | pfl2(Sp_0459) | 0.0 | formate acetyltransferase | 92.97 | 99.22 | AAK74619 |
| IAPDHHHN_1 | 1235745 | 1237226 | SPD_0310 | 0.0 | UPF0371 protein SPD_0310 | 92.31 | 100.00 | ABJ54480 |
| IAPDHHHN_1 | 753466 | 755712 | metE | 0.0 | methionine biosynthesis enzymes | 91.72 | 100.00 | AAK74738 |
| IAPDHHHN_1 | 72205 | 73203 | recA | 0.0 | DNA recombination and repair | 91.29 | 85.82 | AAL00560 |
| IAPDHHHN_1 | 27148 | 28119 | prsA2 | 0.0 | ribose-phosphate pyrophosphokinase | 90.12 | 100.00 | ABF36968 |
| IAPDHHHN_1 | 1393328 | 1392177 | potA | 0.0 | ABC transporter ATP-binding protein-spermidine/putrescine transport | 89.06 | 99.74 | AAL00050 |
| IAPDHHHN_1 | 1365331 | 1363343 | uvrB | 0.0 | excinuclease ABC, B subunit | 88.84 | 100.00 | AE014259_2 |
| IAPDHHHN_1 | 1149232 | 1147502 | ptsI | 0.0 | phosphoenolpyruvate-protein phosphotransferase | 88.04 | 100.00 | AAK34199 |
| IAPDHHHN_1 | 1832211 | 1830733 | IMPDH | 0.0 | inosine-5'-monophosphate dehydrogenase | 87.42 | 100.00 | ADE32434 |
| IAPDHHHN_1 | 1817022 | 1815130 | gidA | 0.0 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme | 86.05 | 98.90 | ABP91129 |
| IAPDHHHN_1 | 1045181 | 1046890 | PGM | 0.0 | phosphoglucomutase | 84.06 | 99.65 | ACH87041 |
| IAPDHHHN_1 | 1674017 | 1675027 | pdh | 0.0 | pyruvate dehydrogenase | 83.09 | 99.70 | ABP91006 |
| IAPDHHHN_1 | 890862 | 892223 | mnmE | 0.0 | central tRNA-modifying GTPase | 82.24 | 99.56 | ABP90420 |
| IAPDHHHN_1 | 1726023 | 1724131 | PepO | 0.0 | endopeptidase | 80.19 | 100.00 | ABF32980 |
| IAPDHHHN_1 | 606909 | 607799 | bglB | 1.32e-178 | putative phospho--glucosidase | 88.89 | 99.66 | AAK33487 |
| IAPDHHHN_1 | 974112 | 975047 | SP_0676 | 7.35e-168 | transcription facot | 81.73 | 96.89 | AAK74821 |
| IAPDHHHN_1 | 755904 | 756761 | metF | 1.52e-164 | methionine biosynthesis enzymes | 86.36 | 99.31 | AAK74739 |
| IAPDHHHN_1 | 773084 | 773788 | covR | 4.36e-131 | responder protein | 85.53 | 100.00 | AAK71319 |
| IAPDHHHN_1 | 1216768 | 1216097 | rr01 | 2.99e-124 | response regulator | 83.93 | 99.56 | CAB54566 |
| IAPDHHHN_1 | 773084 | 773788 | walR | 1.83e-121 | DNA-binding response regulator | 82.13 | 100.00 | ANC99504 |
| IAPDHHHN_1 | 315663 | 316349 | CovR | 1.02e-117 | serves to repress GAS virulence factor-encoding genes | 80.79 | 100.00 | ACE75886 |
| IAPDHHHN_1 | 1041227 | 1040559 | CiaR | 2.01e-117 | two-component response regulator | 84.31 | 99.55 | AAK74935 |
| IAPDHHHN_1 | 1041227 | 1040556 | ciaR | 1.98e-115 | two component system response regulator | 82.14 | 99.12 | AIK75708 |
| IAPDHHHN_1 | 73479 | 73853 | SpxA2 | 1.15e-69 | transcriptional regulator | 91.20 | 94.70 | ERL21461 |
| IAPDHHHN_1 | 879503 | 879102 | SpxA1 | 3.74e-66 | transcriptional regulator | 80.60 | 100.00 | ERL19273 |
| IAPDHHHN_1 | 161275 | 161775 | RopE (M5005_Spy_1611) | 4.90e-75 | probable DNA-directed RNA polymerase subunit delta | 81.44 | 87.43 | AAK34603 |
| IAPDHHHN_1 | 1508921 | 1511218 | PFL (B9H01_RS01125) | 0.0 | formate C-acetyltransferase | 82.94 | 98.08 | MYN69560 |
| IAPDHHHN_1 | 1711562 | 1710543 | ilvC (SPD_0406) | 0.0 | ketol-acid reductoisomerase (NADP(+)) | 96.47 | 100.00 | ABJ55451 |
BLASTX v2.16.0 (Database: PHI base v4.16, May. 2024 release)
Plasmid
PlasmidFinder
| Query ID | Begin | End | Plasmid | Query / Template | Identity | Accession no. |
|---|---|---|---|---|---|---|
| No hit found | ||||||
PlasmidFinder v 2.1.6 (Database: plasmidfinder_db v 2.2.0 , Nov. 2024 release)
PlasmidHunter
| Query ID | Prediction | Chromosome | Plasmid |
|---|---|---|---|
| IAPDHHHN_1 | 0.0 | 1.0 | 0.0 |
PlasmidHunter v 1.4.5 (Database: May. 2024 release)
Prophage
Phigaro
| Query ID | Begin | End | Transposable | Taxonomy | pVOGs |
|---|---|---|---|---|---|
| No hit found | |||||
Phigaro v2.4.0 (Database: Jan. 2024 release)