Probiotic potential risk score
| ARGs | VFs | PGs | PPRS |
|---|---|---|---|
| 0 | 19 | 29 | 34.67 |
PPRS is classified as low-risk (≤4), medium-risk (4-6), and high-risk (≥6).
Antibiotic resistance genes
Comprehensive Antibiotic Resistance Database (CARD)
| Query ID | Begin | End | ARO name | ARO accession | CARD name | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
RGI v6.0.3 (Database: CARD Variants v4.0.2, Nov. 2023 release)
ResFinder
| Query ID | Begin | End | Resistance gene | Phenotype | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|
| No hit found | |||||||
ResFinder v4.6.0 (Database: resfinder_db, Aug. 2024 release)
AMRFinderPlus
| Query ID | Begin | End | Gene symbol | Sequence name | Method | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
AMRFinderPlus v4.0.3 (Database: Oct. 2024 release)
Virulence factors
Virulence Factor Database (VFDB)
| Query ID | qstart | qend | Gene name | e-value | VF name | VF category | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|---|
| NOMLPFEP_1 | 1118356 | 1119225 | rfbA | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011681286 |
| NOMLPFEP_1 | 1117763 | 1118356 | STER_RS06030 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011226149 |
| NOMLPFEP_1 | 1117763 | 1118356 | STR_RS05880 | 0.0 | Capsule | Immune modulation | 99.83 | 100.00 | WP_011226149 |
| NOMLPFEP_1 | 996253 | 996984 | STER_RS05315 | 0.0 | Capsule | Immune modulation | 99.73 | 100.00 | WP_011681176 |
| NOMLPFEP_1 | 1117763 | 1118356 | STU_RS15260 | 0.0 | Capsule | Immune modulation | 99.66 | 100.00 | WP_011226149 |
| NOMLPFEP_1 | 882976 | 884634 | fbp54 | 0.0 | FBPs | Adherence | 99.58 | 100.00 | WP_011227179 |
| NOMLPFEP_1 | 43631 | 44470 | cbpD | 0.0 | Autolysin | Exoenzyme | 99.41 | 100.00 | WP_011226733 |
| NOMLPFEP_1 | 994802 | 995542 | STER_RS05305 | 0.0 | Capsule | Immune modulation | 98.52 | 100.00 | WP_011681174 |
| NOMLPFEP_1 | 994802 | 995542 | STU_RS14635 | 0.0 | Capsule | Immune modulation | 98.38 | 100.00 | WP_011226046 |
| NOMLPFEP_1 | 1348266 | 1348982 | STER_RS07085 | 0.0 | Capsule | Immune modulation | 98.19 | 100.00 | WP_011681442 |
| NOMLPFEP_1 | 994807 | 995542 | STR_RS05250 | 0.0 | Capsule | Immune modulation | 98.10 | 98.13 | WP_011227246 |
| NOMLPFEP_1 | 996253 | 996984 | STR_RS05260 | 0.0 | Capsule | Immune modulation | 97.95 | 100.00 | WP_011227248 |
| NOMLPFEP_1 | 996253 | 996984 | STU_RS14645 | 0.0 | Capsule | Immune modulation | 97.81 | 100.00 | WP_011226048 |
| NOMLPFEP_1 | 1153127 | 1153888 | srtA | 0.0 | Sortase A | Exoenzyme | 97.77 | 100.00 | - |
| NOMLPFEP_1 | 996985 | 998445 | STER_RS05320 | 0.0 | Capsule | Immune modulation | 97.67 | 100.00 | WP_011681177 |
| NOMLPFEP_1 | 1353125 | 1353976 | rfbD | 0.0 | Capsule | Immune modulation | 97.42 | 100.00 | WP_014621820 |
| NOMLPFEP_1 | 996985 | 998445 | STU_RS14650 | 0.0 | Capsule | Immune modulation | 96.51 | 100.21 | WP_011226049 |
| NOMLPFEP_1 | 996985 | 998445 | STR_RS05265 | 0.0 | Capsule | Immune modulation | 95.69 | 100.21 | WP_041827043 |
| NOMLPFEP_1 | 993381 | 994746 | STER_RS05300 | 0.0 | Capsule | Immune modulation | 95.39 | 99.85 | WP_011681173 |
| NOMLPFEP_1 | 1347150 | 1347920 | STER_RS07075 | 0.0 | Capsule | Immune modulation | 94.43 | 99.10 | WP_011681440 |
| NOMLPFEP_1 | 993379 | 994746 | STU_RS14630 | 0.0 | Capsule | Immune modulation | 94.37 | 100.00 | WP_011226045 |
| NOMLPFEP_1 | 1062866 | 1063644 | cshA | 0.0 | Cell surface hydrophobicity proteins | Adherence | 93.19 | 99.37 | - |
| NOMLPFEP_1 | 995552 | 996244 | STER_RS05310 | 0.0 | Capsule | Immune modulation | 92.50 | 100.00 | WP_011681175 |
| NOMLPFEP_1 | 615307 | 616610 | eno | 0.0 | Streptococcal enolase | Exoenzyme | 88.10 | 99.46 | WP_000022832 |
| NOMLPFEP_1 | 995552 | 996244 | STU_RS14640 | 0.0 | Capsule | Immune modulation | 87.88 | 100.00 | WP_011226047 |
| NOMLPFEP_1 | 995552 | 996244 | STR_RS05255 | 0.0 | Capsule | Immune modulation | 87.59 | 100.00 | WP_011227247 |
| NOMLPFEP_1 | 1645894 | 1646904 | plr/gapA | 0.0 | Streptococcal plasmin receptor/GAPDH | Adherence | 87.46 | 99.80 | WP_002986042 |
| NOMLPFEP_1 | 145502 | 146785 | tig/ropA | 0.0 | Trigger factor | Stress survival | 80.73 | 99.77 | WP_000107753 |
| NOMLPFEP_1 | 1116288 | 1117334 | rfbB | 0.0 | Capsule | Immune modulation | 80.61 | 100.00 | WP_009659423 |
| NOMLPFEP_1 | 983848 | 984431 | SPD_RS01775 | 1.10e-146 | Capsule | Immune modulation | 83.11 | 96.04 | WP_001819836 |
BLASTN v2.16.0 (Database: VFDB, Dec. 2024 release)
VirulenceFinder
| Query ID | Begin | End | Database | Virulence factor | Protein function | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
VirulenceFinder v2.0. 4 (Database: virulencefinder_db, Feb . 2024 release)
Pathogenic genes
PHI-base
| Query ID | qstart | qend | Gene name | e-value | Function | Identity | Coverage | Gene ID |
|---|---|---|---|---|---|---|---|---|
| NOMLPFEP_1 | 724836 | 725909 | MntE | 0.0 | manganese homeostasis | 94.41 | 99.72 | ABF32167 |
| NOMLPFEP_1 | 1156575 | 1157558 | ldh(Sp_1220) | 0.0 | L-lactate dehydrogenase | 94.21 | 100.00 | AAK75326 |
| NOMLPFEP_1 | 533061 | 534029 | spr0084 | 0.0 | pathogenitcity related | 93.19 | 98.48 | AAK98888 |
| NOMLPFEP_1 | 1524018 | 1526321 | pfl2(Sp_0459) | 0.0 | formate acetyltransferase | 92.97 | 99.22 | AAK74619 |
| NOMLPFEP_1 | 1236792 | 1238273 | SPD_0310 | 0.0 | UPF0371 protein SPD_0310 | 92.71 | 100.00 | ABJ54480 |
| NOMLPFEP_1 | 745360 | 747606 | metE | 0.0 | methionine biosynthesis enzymes | 91.86 | 100.00 | AAK74738 |
| NOMLPFEP_1 | 64482 | 65480 | recA | 0.0 | DNA recombination and repair | 91.29 | 85.82 | AAL00560 |
| NOMLPFEP_1 | 27147 | 28118 | prsA2 | 0.0 | ribose-phosphate pyrophosphokinase | 90.12 | 100.00 | ABF36968 |
| NOMLPFEP_1 | 1402707 | 1401556 | potA | 0.0 | ABC transporter ATP-binding protein-spermidine/putrescine transport | 89.32 | 99.74 | AAL00050 |
| NOMLPFEP_1 | 1367014 | 1365026 | uvrB | 0.0 | excinuclease ABC, B subunit | 88.84 | 100.00 | AE014259_2 |
| NOMLPFEP_1 | 1140376 | 1138646 | ptsI | 0.0 | phosphoenolpyruvate-protein phosphotransferase | 88.04 | 100.00 | AAK34199 |
| NOMLPFEP_1 | 1852337 | 1850859 | IMPDH | 0.0 | inosine-5'-monophosphate dehydrogenase | 87.63 | 100.00 | ADE32434 |
| NOMLPFEP_1 | 615307 | 616608 | Eno | 0.0 | enolase | 86.21 | 99.77 | ABP90468 |
| NOMLPFEP_1 | 1837599 | 1835707 | gidA | 0.0 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme | 85.74 | 98.90 | ABP91129 |
| NOMLPFEP_1 | 750531 | 748822 | PGM | 0.0 | phosphoglucomutase | 84.06 | 99.65 | ACH87041 |
| NOMLPFEP_1 | 1688609 | 1689619 | pdh | 0.0 | pyruvate dehydrogenase | 83.09 | 99.70 | ABP91006 |
| NOMLPFEP_1 | 909610 | 908249 | mnmE | 0.0 | central tRNA-modifying GTPase | 82.24 | 99.56 | ABP90420 |
| NOMLPFEP_1 | 1738944 | 1737052 | PepO | 0.0 | endopeptidase | 80.19 | 100.00 | ABF32980 |
| NOMLPFEP_1 | 600868 | 601758 | bglB | 5.28e-178 | putative phospho--glucosidase | 88.55 | 99.66 | AAK33487 |
| NOMLPFEP_1 | 829200 | 828265 | SP_0676 | 7.43e-168 | transcription facot | 81.73 | 96.89 | AAK74821 |
| NOMLPFEP_1 | 747798 | 748655 | metF | 1.54e-164 | methionine biosynthesis enzymes | 86.36 | 99.31 | AAK74739 |
| NOMLPFEP_1 | 1035234 | 1034530 | covR | 4.40e-131 | responder protein | 85.53 | 100.00 | AAK71319 |
| NOMLPFEP_1 | 1208688 | 1208017 | rr01 | 3.02e-124 | response regulator | 83.93 | 99.56 | CAB54566 |
| NOMLPFEP_1 | 754486 | 755154 | CiaR | 8.77e-123 | two-component response regulator | 86.10 | 99.55 | AAK74935 |
| NOMLPFEP_1 | 1035234 | 1034530 | walR | 1.85e-121 | DNA-binding response regulator | 82.13 | 100.00 | ANC99504 |
| NOMLPFEP_1 | 754486 | 755157 | ciaR | 1.19e-120 | two component system response regulator | 83.93 | 99.12 | AIK75708 |
| NOMLPFEP_1 | 298483 | 299169 | CovR | 1.01e-117 | serves to repress GAS virulence factor-encoding genes | 80.79 | 100.00 | ACE75886 |
| NOMLPFEP_1 | 65756 | 66130 | SpxA2 | 1.16e-69 | transcriptional regulator | 91.20 | 94.70 | ERL21461 |
| NOMLPFEP_1 | 921074 | 921475 | SpxA1 | 3.78e-66 | transcriptional regulator | 80.60 | 100.00 | ERL19273 |
| NOMLPFEP_1 | 146943 | 147443 | RopE (M5005_Spy_1611) | 4.95e-75 | probable DNA-directed RNA polymerase subunit delta | 81.44 | 87.43 | AAK34603 |
| NOMLPFEP_1 | 1524018 | 1526315 | PFL (B9H01_RS01125) | 0.0 | formate C-acetyltransferase | 82.94 | 98.08 | MYN69560 |
| NOMLPFEP_1 | 1724489 | 1723470 | ilvC (SPD_0406) | 0.0 | ketol-acid reductoisomerase (NADP(+)) | 96.47 | 100.00 | ABJ55451 |
BLASTX v2.16.0 (Database: PHI base v4.16, May. 2024 release)
Plasmid
PlasmidFinder
| Query ID | Begin | End | Plasmid | Query / Template | Identity | Accession no. |
|---|---|---|---|---|---|---|
| No hit found | ||||||
PlasmidFinder v 2.1.6 (Database: plasmidfinder_db v 2.2.0 , Nov. 2024 release)
PlasmidHunter
| Query ID | Prediction | Chromosome | Plasmid |
|---|---|---|---|
| NOMLPFEP_1 | 0.0 | 1.0 | 0.0 |
PlasmidHunter v 1.4.5 (Database: May. 2024 release)
Prophage
Phigaro
| Query ID | Begin | End | Transposable | Taxonomy | pVOGs |
|---|---|---|---|---|---|
| No hit found | |||||
Phigaro v2.4.0 (Database: Jan. 2024 release)