Probiotic potential risk score
| ARGs | VFs | PGs | PPRS |
|---|---|---|---|
| 0 | 25 | 26 | 36.07 |
PPRS is classified as low-risk (≤4), medium-risk (4-6), and high-risk (≥6).
Antibiotic resistance genes
Comprehensive Antibiotic Resistance Database (CARD)
| Query ID | Begin | End | ARO name | ARO accession | CARD name | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
RGI v6.0.3 (Database: CARD Variants v4.0.2, Nov. 2023 release)
ResFinder
| Query ID | Begin | End | Resistance gene | Phenotype | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|
| No hit found | |||||||
ResFinder v4.6.0 (Database: resfinder_db, Aug. 2024 release)
AMRFinderPlus
| Query ID | Begin | End | Gene symbol | Sequence name | Method | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
AMRFinderPlus v4.0.3 (Database: Oct. 2024 release)
Virulence factors
Virulence Factor Database (VFDB)
| Query ID | qstart | qend | Gene name | e-value | VF name | VF category | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|---|
| ADEMEGCO_1 | 1321154 | 1322302 | STR_RS06910 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011227431 |
| ADEMEGCO_1 | 1314701 | 1316446 | STR_RS06885 | 0.0 | Capsule | Immune modulation | 99.94 | 100.00 | WP_011227426 |
| ADEMEGCO_1 | 1320216 | 1321157 | STR_RS06905 | 0.0 | Capsule | Immune modulation | 99.79 | 100.00 | WP_011227430 |
| ADEMEGCO_1 | 1316550 | 1318190 | STER_RS07050 | 0.0 | Capsule | Immune modulation | 99.76 | 96.47 | WP_041827753 |
| ADEMEGCO_1 | 979924 | 980616 | STU_RS14640 | 0.0 | Capsule | Immune modulation | 99.71 | 100.00 | WP_011226047 |
| ADEMEGCO_1 | 1320216 | 1321157 | STER_RS07065 | 0.0 | Capsule | Immune modulation | 99.68 | 100.00 | WP_011681438 |
| ADEMEGCO_1 | 1108646 | 1109239 | STR_RS05880 | 0.0 | Capsule | Immune modulation | 99.66 | 100.00 | WP_011226149 |
| ADEMEGCO_1 | 43624 | 44462 | cbpD | 0.0 | Autolysin | Exoenzyme | 99.64 | 99.88 | WP_011226733 |
| ADEMEGCO_1 | 1319410 | 1320216 | STER_RS07060 | 0.0 | Capsule | Immune modulation | 99.63 | 100.00 | WP_011681437 |
| ADEMEGCO_1 | 1319410 | 1320216 | STR_RS06900 | 0.0 | Capsule | Immune modulation | 99.63 | 100.00 | WP_011227429 |
| ADEMEGCO_1 | 1318208 | 1319410 | STER_RS07055 | 0.0 | Capsule | Immune modulation | 99.58 | 100.00 | WP_011681436 |
| ADEMEGCO_1 | 1316550 | 1318190 | STR_RS06890 | 0.0 | Capsule | Immune modulation | 99.57 | 96.47 | WP_041827077 |
| ADEMEGCO_1 | 1108646 | 1109239 | STER_RS06030 | 0.0 | Capsule | Immune modulation | 99.50 | 100.00 | WP_011226149 |
| ADEMEGCO_1 | 1318208 | 1319410 | STR_RS06895 | 0.0 | Capsule | Immune modulation | 99.50 | 100.00 | WP_011227428 |
| ADEMEGCO_1 | 1108646 | 1109239 | STU_RS15260 | 0.0 | Capsule | Immune modulation | 99.50 | 100.00 | WP_011226149 |
| ADEMEGCO_1 | 1327218 | 1328069 | rfbD | 0.0 | Capsule | Immune modulation | 99.41 | 100.00 | WP_014621820 |
| ADEMEGCO_1 | 858957 | 860615 | fbp54 | 0.0 | FBPs | Adherence | 99.40 | 100.00 | WP_011227179 |
| ADEMEGCO_1 | 1321154 | 1322302 | STER_RS07070 | 0.0 | Capsule | Immune modulation | 99.22 | 100.00 | WP_011681439 |
| ADEMEGCO_1 | 979924 | 980616 | STR_RS05255 | 0.0 | Capsule | Immune modulation | 99.13 | 100.00 | WP_011227247 |
| ADEMEGCO_1 | 1109239 | 1110108 | rfbA | 0.0 | Capsule | Immune modulation | 99.08 | 100.00 | WP_011681286 |
| ADEMEGCO_1 | 1053937 | 1054727 | cshA | 0.0 | Cell surface hydrophobicity proteins | Adherence | 98.86 | 100.00 | - |
| ADEMEGCO_1 | 977750 | 979117 | STU_RS14630 | 0.0 | Capsule | Immune modulation | 98.83 | 100.00 | WP_011226045 |
| ADEMEGCO_1 | 1144004 | 1144765 | srtA | 0.0 | Sortase A | Exoenzyme | 98.69 | 100.00 | - |
| ADEMEGCO_1 | 980625 | 981355 | STU_RS14645 | 0.0 | Capsule | Immune modulation | 98.63 | 99.86 | WP_011226048 |
| ADEMEGCO_1 | 980625 | 981355 | STR_RS05260 | 0.0 | Capsule | Immune modulation | 98.50 | 99.86 | WP_011227248 |
| ADEMEGCO_1 | 979174 | 979914 | STER_RS05305 | 0.0 | Capsule | Immune modulation | 98.38 | 100.00 | WP_011681174 |
| ADEMEGCO_1 | 980625 | 981355 | STER_RS05315 | 0.0 | Capsule | Immune modulation | 98.36 | 99.86 | WP_011681176 |
| ADEMEGCO_1 | 1314701 | 1316446 | STER_RS07045 | 0.0 | Capsule | Immune modulation | 98.28 | 100.00 | WP_011681434 |
| ADEMEGCO_1 | 963203 | 964618 | STER_RS05250 | 0.0 | Capsule | Immune modulation | 98.23 | 100.00 | WP_011681165 |
| ADEMEGCO_1 | 979174 | 979914 | STU_RS14635 | 0.0 | Capsule | Immune modulation | 97.71 | 100.00 | WP_011226046 |
| ADEMEGCO_1 | 1325840 | 1327098 | STER_RS07100 | 0.0 | Capsule | Immune modulation | 97.70 | 99.92 | WP_011681445 |
| ADEMEGCO_1 | 981356 | 982816 | STER_RS05320 | 0.0 | Capsule | Immune modulation | 97.54 | 100.00 | WP_011681177 |
| ADEMEGCO_1 | 979179 | 979914 | STR_RS05250 | 0.0 | Capsule | Immune modulation | 97.42 | 98.13 | WP_011227246 |
| ADEMEGCO_1 | 981356 | 982816 | STU_RS14650 | 0.0 | Capsule | Immune modulation | 96.51 | 100.21 | WP_011226049 |
| ADEMEGCO_1 | 981356 | 982816 | STR_RS05265 | 0.0 | Capsule | Immune modulation | 95.83 | 100.21 | WP_041827043 |
| ADEMEGCO_1 | 977754 | 979117 | STER_RS05300 | 0.0 | Capsule | Immune modulation | 94.65 | 99.71 | WP_011681173 |
| ADEMEGCO_1 | 979924 | 980616 | STER_RS05310 | 0.0 | Capsule | Immune modulation | 89.61 | 100.00 | WP_011681175 |
| ADEMEGCO_1 | 604694 | 605997 | eno | 0.0 | Streptococcal enolase | Exoenzyme | 88.17 | 99.54 | WP_000022832 |
| ADEMEGCO_1 | 1625821 | 1626831 | plr/gapA | 0.0 | Streptococcal plasmin receptor/GAPDH | Adherence | 86.82 | 99.51 | WP_002986042 |
| ADEMEGCO_1 | 1319410 | 1320216 | SGO_RS05020 | 0.0 | Capsule | Immune modulation | 82.78 | 100.00 | WP_012000440 |
| ADEMEGCO_1 | 1107171 | 1108217 | rfbB | 0.0 | Capsule | Immune modulation | 80.61 | 100.00 | WP_009659423 |
| ADEMEGCO_1 | 145601 | 146884 | tig/ropA | 0.0 | Trigger factor | Stress survival | 80.50 | 99.77 | WP_000107753 |
| ADEMEGCO_1 | 1325146 | 1325843 | STER_RS07095 | 2.32e-148 | Capsule | Immune modulation | 80.87 | 70.25 | WP_011681444 |
| ADEMEGCO_1 | 1324326 | 1324792 | STER_RS07085 | 0.0 | Capsule | Immune modulation | 94.44 | 65.13 | WP_011681442 |
| ADEMEGCO_1 | 1318673 | 1319410 | SGO_RS05025 | 0.0 | Capsule | Immune modulation | 84.96 | 60.29 | WP_012000441 |
BLASTN v2.16.0 (Database: VFDB, Dec. 2024 release)
VirulenceFinder
| Query ID | Begin | End | Database | Virulence factor | Protein function | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
VirulenceFinder v2.0. 4 (Database: virulencefinder_db, Feb . 2024 release)
Pathogenic genes
PHI-base
| Query ID | qstart | qend | Gene name | e-value | Function | Identity | Coverage | Gene ID |
|---|---|---|---|---|---|---|---|---|
| ADEMEGCO_1 | 1147452 | 1148435 | ldh(Sp_1220) | 0.0 | L-lactate dehydrogenase | 94.82 | 100.00 | AAK75326 |
| ADEMEGCO_1 | 707789 | 708862 | MntE | 0.0 | manganese homeostasis | 94.41 | 99.72 | ABF32167 |
| ADEMEGCO_1 | 517682 | 518650 | spr0084 | 0.0 | pathogenitcity related | 93.19 | 98.48 | AAK98888 |
| ADEMEGCO_1 | 1501459 | 1503762 | pfl2(Sp_0459) | 0.0 | formate acetyltransferase | 93.10 | 99.22 | AAK74619 |
| ADEMEGCO_1 | 1224347 | 1225828 | SPD_0310 | 0.0 | UPF0371 protein SPD_0310 | 92.11 | 100.00 | ABJ54480 |
| ADEMEGCO_1 | 63258 | 64256 | recA | 0.0 | DNA recombination and repair | 91.29 | 85.82 | AAL00560 |
| ADEMEGCO_1 | 27146 | 28117 | prsA2 | 0.0 | ribose-phosphate pyrophosphokinase | 90.12 | 100.00 | ABF36968 |
| ADEMEGCO_1 | 1378305 | 1377154 | potA | 0.0 | ABC transporter ATP-binding protein-spermidine/putrescine transport | 89.32 | 99.74 | AAL00050 |
| ADEMEGCO_1 | 1341247 | 1339259 | uvrB | 0.0 | excinuclease ABC, B subunit | 88.99 | 100.00 | AE014259_2 |
| ADEMEGCO_1 | 1131257 | 1129527 | ptsI | 0.0 | phosphoenolpyruvate-protein phosphotransferase | 87.69 | 100.00 | AAK34199 |
| ADEMEGCO_1 | 1818784 | 1817306 | IMPDH | 0.0 | inosine-5'-monophosphate dehydrogenase | 87.63 | 100.00 | ADE32434 |
| ADEMEGCO_1 | 604694 | 605995 | Eno | 0.0 | enolase | 86.21 | 99.77 | ABP90468 |
| ADEMEGCO_1 | 1804050 | 1802158 | gidA | 0.0 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme | 86.05 | 98.90 | ABP91129 |
| ADEMEGCO_1 | 744352 | 742643 | PGM | 0.0 | phosphoglucomutase | 83.89 | 99.65 | ACH87041 |
| ADEMEGCO_1 | 1670212 | 1671222 | pdh | 0.0 | pyruvate dehydrogenase | 83.09 | 99.70 | ABP91006 |
| ADEMEGCO_1 | 897959 | 896598 | mnmE | 0.0 | central tRNA-modifying GTPase | 82.24 | 99.56 | ABP90420 |
| ADEMEGCO_1 | 590261 | 591151 | bglB | 1.31e-178 | putative phospho--glucosidase | 88.89 | 99.66 | AAK33487 |
| ADEMEGCO_1 | 803570 | 802632 | SP_0676 | 8.11e-168 | transcription facot | 81.47 | 97.20 | AAK74821 |
| ADEMEGCO_1 | 740194 | 741051 | metF | 1.48e-164 | methionine biosynthesis enzymes | 86.01 | 99.31 | AAK74739 |
| ADEMEGCO_1 | 1020894 | 1020190 | covR | 1.05e-130 | responder protein | 85.11 | 100.00 | AAK71319 |
| ADEMEGCO_1 | 1205380 | 1204709 | rr01 | 4.08e-126 | response regulator | 84.82 | 99.56 | CAB54566 |
| ADEMEGCO_1 | 1020894 | 1020190 | walR | 5.28e-121 | DNA-binding response regulator | 81.28 | 100.00 | ANC99504 |
| ADEMEGCO_1 | 748305 | 748973 | CiaR | 1.05e-119 | two-component response regulator | 85.20 | 99.55 | AAK74935 |
| ADEMEGCO_1 | 303481 | 304167 | CovR | 9.93e-118 | serves to repress GAS virulence factor-encoding genes | 80.79 | 100.00 | ACE75886 |
| ADEMEGCO_1 | 748305 | 748976 | ciaR | 1.17e-117 | two component system response regulator | 83.04 | 99.12 | AIK75708 |
| ADEMEGCO_1 | 909341 | 909742 | SpxA1 | 3.71e-66 | transcriptional regulator | 80.60 | 100.00 | ERL19273 |
| ADEMEGCO_1 | 147042 | 147542 | RopE (M5005_Spy_1611) | 4.86e-75 | probable DNA-directed RNA polymerase subunit delta | 81.44 | 87.43 | AAK34603 |
| ADEMEGCO_1 | 1501459 | 1503756 | PFL (B9H01_RS01125) | 0.0 | formate C-acetyltransferase | 83.07 | 98.08 | MYN69560 |
| ADEMEGCO_1 | 1707754 | 1706735 | ilvC (SPD_0406) | 0.0 | ketol-acid reductoisomerase (NADP(+)) | 96.47 | 100.00 | ABJ55451 |
BLASTX v2.16.0 (Database: PHI base v4.16, May. 2024 release)
Plasmid
PlasmidFinder
| Query ID | Begin | End | Plasmid | Query / Template | Identity | Accession no. |
|---|---|---|---|---|---|---|
| No hit found | ||||||
PlasmidFinder v 2.1.6 (Database: plasmidfinder_db v 2.2.0 , Nov. 2024 release)
PlasmidHunter
| Query ID | Prediction | Chromosome | Plasmid |
|---|---|---|---|
| ADEMEGCO_1 | 0.0 | 1.0 | 0.0 |
PlasmidHunter v 1.4.5 (Database: May. 2024 release)
Prophage
Phigaro
| Query ID | Begin | End | Transposable | Taxonomy | pVOGs |
|---|---|---|---|---|---|
| No hit found | |||||
Phigaro v2.4.0 (Database: Jan. 2024 release)