Probiotic potential risk score
| ARGs | VFs | PGs | PPRS |
|---|---|---|---|
| 0 | 22 | 28 | 35.61 |
PPRS is classified as low-risk (≤4), medium-risk (4-6), and high-risk (≥6).
Antibiotic resistance genes
Comprehensive Antibiotic Resistance Database (CARD)
| Query ID | Begin | End | ARO name | ARO accession | CARD name | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
RGI v6.0.3 (Database: CARD Variants v4.0.2, Nov. 2023 release)
ResFinder
| Query ID | Begin | End | Resistance gene | Phenotype | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|
| No hit found | |||||||
ResFinder v4.6.0 (Database: resfinder_db, Aug. 2024 release)
AMRFinderPlus
| Query ID | Begin | End | Gene symbol | Sequence name | Method | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
AMRFinderPlus v4.0.3 (Database: Oct. 2024 release)
Virulence factors
Virulence Factor Database (VFDB)
| Query ID | qstart | qend | Gene name | e-value | VF name | VF category | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|---|
| KFONPNDC_1 | 1121388 | 1122257 | rfbA | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011681286 |
| KFONPNDC_1 | 1120795 | 1121388 | STER_RS06030 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011226149 |
| KFONPNDC_1 | 1342273 | 1343241 | STER_RS07090 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011681443 |
| KFONPNDC_1 | 1120795 | 1121388 | STR_RS05880 | 0.0 | Capsule | Immune modulation | 99.83 | 100.00 | WP_011226149 |
| KFONPNDC_1 | 1120795 | 1121388 | STU_RS15260 | 0.0 | Capsule | Immune modulation | 99.66 | 100.00 | WP_011226149 |
| KFONPNDC_1 | 912940 | 914598 | fbp54 | 0.0 | FBPs | Adherence | 99.58 | 100.00 | WP_011227179 |
| KFONPNDC_1 | 43631 | 44470 | cbpD | 0.0 | Autolysin | Exoenzyme | 99.41 | 100.00 | WP_011226733 |
| KFONPNDC_1 | 1343259 | 1344236 | STER_RS07095 | 0.0 | Capsule | Immune modulation | 99.39 | 100.00 | WP_011681444 |
| KFONPNDC_1 | 805545 | 806276 | STR_RS05260 | 0.0 | Capsule | Immune modulation | 98.91 | 100.00 | WP_011227248 |
| KFONPNDC_1 | 1156156 | 1156917 | srtA | 0.0 | Sortase A | Exoenzyme | 98.82 | 100.00 | - |
| KFONPNDC_1 | 806987 | 807727 | STU_RS14635 | 0.0 | Capsule | Immune modulation | 98.52 | 100.00 | WP_011226046 |
| KFONPNDC_1 | 815582 | 816859 | STR_RS05265 | 0.0 | Capsule | Immune modulation | 98.51 | 87.84 | WP_041827043 |
| KFONPNDC_1 | 815582 | 816859 | STU_RS14650 | 0.0 | Capsule | Immune modulation | 98.51 | 87.84 | WP_011226049 |
| KFONPNDC_1 | 805545 | 806276 | STER_RS05315 | 0.0 | Capsule | Immune modulation | 98.50 | 100.00 | WP_011681176 |
| KFONPNDC_1 | 806987 | 807727 | STER_RS05305 | 0.0 | Capsule | Immune modulation | 98.38 | 100.00 | WP_011681174 |
| KFONPNDC_1 | 1063143 | 1063936 | cshA | 0.0 | Cell surface hydrophobicity proteins | Adherence | 98.36 | 100.25 | - |
| KFONPNDC_1 | 1341556 | 1342272 | STER_RS07085 | 0.0 | Capsule | Immune modulation | 98.19 | 100.00 | WP_011681442 |
| KFONPNDC_1 | 806285 | 806977 | STR_RS05255 | 0.0 | Capsule | Immune modulation | 98.12 | 100.00 | WP_011227247 |
| KFONPNDC_1 | 806285 | 806977 | STU_RS14640 | 0.0 | Capsule | Immune modulation | 98.12 | 100.00 | WP_011226047 |
| KFONPNDC_1 | 806987 | 807722 | STR_RS05250 | 0.0 | Capsule | Immune modulation | 97.83 | 98.13 | WP_011227246 |
| KFONPNDC_1 | 805545 | 806276 | STU_RS14645 | 0.0 | Capsule | Immune modulation | 97.68 | 100.00 | WP_011226048 |
| KFONPNDC_1 | 815582 | 816859 | STER_RS05320 | 0.0 | Capsule | Immune modulation | 97.20 | 87.68 | WP_011681177 |
| KFONPNDC_1 | 1345610 | 1346461 | rfbD | 0.0 | Capsule | Immune modulation | 97.07 | 100.00 | WP_014621820 |
| KFONPNDC_1 | 1340440 | 1341210 | STER_RS07075 | 0.0 | Capsule | Immune modulation | 96.89 | 99.10 | WP_011681440 |
| KFONPNDC_1 | 1344233 | 1345491 | STER_RS07100 | 0.0 | Capsule | Immune modulation | 96.51 | 99.92 | WP_011681445 |
| KFONPNDC_1 | 807784 | 809151 | STU_RS14630 | 0.0 | Capsule | Immune modulation | 96.42 | 100.00 | WP_011226045 |
| KFONPNDC_1 | 807784 | 809149 | STER_RS05300 | 0.0 | Capsule | Immune modulation | 94.14 | 99.85 | WP_011681173 |
| KFONPNDC_1 | 806285 | 806977 | STER_RS05310 | 0.0 | Capsule | Immune modulation | 89.90 | 100.00 | WP_011681175 |
| KFONPNDC_1 | 615529 | 616832 | eno | 0.0 | Streptococcal enolase | Exoenzyme | 88.10 | 99.46 | WP_000022832 |
| KFONPNDC_1 | 1624761 | 1625771 | plr/gapA | 0.0 | Streptococcal plasmin receptor/GAPDH | Adherence | 87.46 | 99.80 | WP_002986042 |
| KFONPNDC_1 | 154025 | 155308 | tig/ropA | 0.0 | Trigger factor | Stress survival | 80.73 | 99.77 | WP_000107753 |
| KFONPNDC_1 | 1119320 | 1120366 | rfbB | 0.0 | Capsule | Immune modulation | 80.52 | 100.00 | WP_009659423 |
| KFONPNDC_1 | 819243 | 819826 | SPD_RS01775 | 2.33e-148 | Capsule | Immune modulation | 83.25 | 96.20 | WP_001819836 |
BLASTN v2.16.0 (Database: VFDB, Dec. 2024 release)
VirulenceFinder
| Query ID | Begin | End | Database | Virulence factor | Protein function | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
VirulenceFinder v2.0. 4 (Database: virulencefinder_db, Feb . 2024 release)
Pathogenic genes
PHI-base
| Query ID | qstart | qend | Gene name | e-value | Function | Identity | Coverage | Gene ID |
|---|---|---|---|---|---|---|---|---|
| KFONPNDC_1 | 1159604 | 1160587 | ldh(Sp_1220) | 0.0 | L-lactate dehydrogenase | 94.82 | 100.00 | AAK75326 |
| KFONPNDC_1 | 725705 | 726778 | MntE | 0.0 | manganese homeostasis | 94.41 | 99.72 | ABF32167 |
| KFONPNDC_1 | 531895 | 532863 | spr0084 | 0.0 | pathogenitcity related | 93.19 | 98.48 | AAK98888 |
| KFONPNDC_1 | 1503090 | 1505393 | pfl2(Sp_0459) | 0.0 | formate acetyltransferase | 92.97 | 99.22 | AAK74619 |
| KFONPNDC_1 | 1229917 | 1231398 | SPD_0310 | 0.0 | UPF0371 protein SPD_0310 | 92.31 | 100.00 | ABJ54480 |
| KFONPNDC_1 | 747650 | 749896 | metE | 0.0 | methionine biosynthesis enzymes | 91.72 | 100.00 | AAK74738 |
| KFONPNDC_1 | 72204 | 73202 | recA | 0.0 | DNA recombination and repair | 91.29 | 85.82 | AAL00560 |
| KFONPNDC_1 | 27148 | 28119 | prsA2 | 0.0 | ribose-phosphate pyrophosphokinase | 90.12 | 100.00 | ABF36968 |
| KFONPNDC_1 | 1387497 | 1386346 | potA | 0.0 | ABC transporter ATP-binding protein-spermidine/putrescine transport | 89.06 | 99.74 | AAL00050 |
| KFONPNDC_1 | 1359500 | 1357512 | uvrB | 0.0 | excinuclease ABC, B subunit | 88.84 | 100.00 | AE014259_2 |
| KFONPNDC_1 | 1143408 | 1141678 | ptsI | 0.0 | phosphoenolpyruvate-protein phosphotransferase | 88.04 | 100.00 | AAK34199 |
| KFONPNDC_1 | 1826344 | 1824866 | IMPDH | 0.0 | inosine-5'-monophosphate dehydrogenase | 87.42 | 100.00 | ADE32434 |
| KFONPNDC_1 | 615529 | 616830 | Eno | 0.0 | enolase | 86.21 | 99.77 | ABP90468 |
| KFONPNDC_1 | 1811155 | 1809263 | gidA | 0.0 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme | 86.05 | 98.90 | ABP91129 |
| KFONPNDC_1 | 1039359 | 1041068 | PGM | 0.0 | phosphoglucomutase | 84.06 | 99.65 | ACH87041 |
| KFONPNDC_1 | 1668152 | 1669162 | pdh | 0.0 | pyruvate dehydrogenase | 83.09 | 99.70 | ABP91006 |
| KFONPNDC_1 | 885043 | 886404 | mnmE | 0.0 | central tRNA-modifying GTPase | 82.24 | 99.56 | ABP90420 |
| KFONPNDC_1 | 1720158 | 1718266 | PepO | 0.0 | endopeptidase | 80.19 | 100.00 | ABF32980 |
| KFONPNDC_1 | 601096 | 601986 | bglB | 1.32e-178 | putative phospho--glucosidase | 88.89 | 99.66 | AAK33487 |
| KFONPNDC_1 | 968293 | 969228 | SP_0676 | 7.32e-168 | transcription facot | 81.73 | 96.89 | AAK74821 |
| KFONPNDC_1 | 750088 | 750945 | metF | 1.52e-164 | methionine biosynthesis enzymes | 86.36 | 99.31 | AAK74739 |
| KFONPNDC_1 | 767268 | 767972 | covR | 4.34e-131 | responder protein | 85.53 | 100.00 | AAK71319 |
| KFONPNDC_1 | 1210941 | 1210270 | rr01 | 2.98e-124 | response regulator | 83.93 | 99.56 | CAB54566 |
| KFONPNDC_1 | 767268 | 767972 | walR | 1.83e-121 | DNA-binding response regulator | 82.13 | 100.00 | ANC99504 |
| KFONPNDC_1 | 309853 | 310539 | CovR | 1.02e-117 | serves to repress GAS virulence factor-encoding genes | 80.79 | 100.00 | ACE75886 |
| KFONPNDC_1 | 1035405 | 1034737 | CiaR | 2.00e-117 | two-component response regulator | 84.31 | 99.55 | AAK74935 |
| KFONPNDC_1 | 1035405 | 1034734 | ciaR | 1.97e-115 | two component system response regulator | 82.14 | 99.12 | AIK75708 |
| KFONPNDC_1 | 73478 | 73852 | SpxA2 | 1.14e-69 | transcriptional regulator | 91.20 | 94.70 | ERL21461 |
| KFONPNDC_1 | 873684 | 873283 | SpxA1 | 3.73e-66 | transcriptional regulator | 80.60 | 100.00 | ERL19273 |
| KFONPNDC_1 | 1503090 | 1505387 | PFL (B9H01_RS01125) | 0.0 | formate C-acetyltransferase | 82.94 | 98.08 | MYN69560 |
| KFONPNDC_1 | 1705697 | 1704678 | ilvC (SPD_0406) | 0.0 | ketol-acid reductoisomerase (NADP(+)) | 96.47 | 100.00 | ABJ55451 |
BLASTX v2.16.0 (Database: PHI base v4.16, May. 2024 release)
Plasmid
PlasmidFinder
| Query ID | Begin | End | Plasmid | Query / Template | Identity | Accession no. |
|---|---|---|---|---|---|---|
| No hit found | ||||||
PlasmidFinder v 2.1.6 (Database: plasmidfinder_db v 2.2.0 , Nov. 2024 release)
PlasmidHunter
| Query ID | Prediction | Chromosome | Plasmid |
|---|---|---|---|
| KFONPNDC_1 | 0.0 | 1.0 | 0.0 |
PlasmidHunter v 1.4.5 (Database: May. 2024 release)
Prophage
Phigaro
| Query ID | Begin | End | Transposable | Taxonomy | pVOGs |
|---|---|---|---|---|---|
| No hit found | |||||
Phigaro v2.4.0 (Database: Jan. 2024 release)