Probiotic potential risk score
| ARGs | VFs | PGs | PPRS |
|---|---|---|---|
| 0 | 28 | 29 | 40.31 |
PPRS is classified as low-risk (≤4), medium-risk (4-6), and high-risk (≥6).
Antibiotic resistance genes
Comprehensive Antibiotic Resistance Database (CARD)
| Query ID | Begin | End | ARO name | ARO accession | CARD name | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
RGI v6.0.3 (Database: CARD Variants v4.0.2, Nov. 2023 release)
ResFinder
| Query ID | Begin | End | Resistance gene | Phenotype | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|
| No hit found | |||||||
ResFinder v4.6.0 (Database: resfinder_db, Aug. 2024 release)
AMRFinderPlus
| Query ID | Begin | End | Gene symbol | Sequence name | Method | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
AMRFinderPlus v4.0.3 (Database: Oct. 2024 release)
Virulence factors
Virulence Factor Database (VFDB)
| Query ID | qstart | qend | Gene name | e-value | VF name | VF category | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|---|
| HPOFIPAE_1 | 43603 | 44442 | cbpD | 0.0 | Autolysin | Exoenzyme | 100.00 | 100.00 | WP_011226733 |
| HPOFIPAE_1 | 1243884 | 1244939 | STU_RS16235 | 0.0 | Capsule | Immune modulation | 99.91 | 100.00 | WP_002948022 |
| HPOFIPAE_1 | 1242103 | 1243887 | STU_RS16230 | 0.0 | Capsule | Immune modulation | 99.83 | 100.00 | WP_011226325 |
| HPOFIPAE_1 | 939145 | 939624 | STR_RS05225 | 0.0 | Capsule | Immune modulation | 99.79 | 100.00 | WP_041827041 |
| HPOFIPAE_1 | 1246957 | 1247913 | STU_RS16250 | 0.0 | Capsule | Immune modulation | 99.79 | 100.00 | WP_011226328 |
| HPOFIPAE_1 | 1246164 | 1246973 | STU_RS16245 | 0.0 | Capsule | Immune modulation | 99.75 | 100.00 | WP_002948020 |
| HPOFIPAE_1 | 1247910 | 1249058 | STU_RS16255 | 0.0 | Capsule | Immune modulation | 99.74 | 100.00 | WP_041828290 |
| HPOFIPAE_1 | 1244959 | 1246164 | STU_RS16240 | 0.0 | Capsule | Immune modulation | 99.67 | 100.00 | WP_011226326 |
| HPOFIPAE_1 | 1056076 | 1056945 | rfbA | 0.0 | Capsule | Immune modulation | 99.66 | 100.00 | WP_011681286 |
| HPOFIPAE_1 | 1055483 | 1056076 | STR_RS05880 | 0.0 | Capsule | Immune modulation | 99.50 | 100.00 | WP_011226149 |
| HPOFIPAE_1 | 841291 | 842949 | fbp54 | 0.0 | FBPs | Adherence | 99.40 | 100.00 | WP_011227179 |
| HPOFIPAE_1 | 1055483 | 1056076 | STER_RS06030 | 0.0 | Capsule | Immune modulation | 99.33 | 100.00 | WP_011226149 |
| HPOFIPAE_1 | 1055483 | 1056076 | STU_RS15260 | 0.0 | Capsule | Immune modulation | 99.33 | 100.00 | WP_011226149 |
| HPOFIPAE_1 | 938209 | 939139 | STR_RS05220 | 0.0 | Capsule | Immune modulation | 99.25 | 95.49 | WP_011227240 |
| HPOFIPAE_1 | 932896 | 934317 | STR_RS05200 | 0.0 | Capsule | Immune modulation | 99.23 | 100.00 | WP_011227236 |
| HPOFIPAE_1 | 1090841 | 1091602 | srtA | 0.0 | Sortase A | Exoenzyme | 99.08 | 100.00 | - |
| HPOFIPAE_1 | 1251716 | 1252990 | STU_RS16265 | 0.0 | Capsule | Immune modulation | 98.90 | 100.00 | WP_011226331 |
| HPOFIPAE_1 | 1010639 | 1011429 | cshA | 0.0 | Cell surface hydrophobicity proteins | Adherence | 98.86 | 99.87 | - |
| HPOFIPAE_1 | 1250754 | 1251716 | STU_RS16260 | 0.0 | Capsule | Immune modulation | 98.86 | 95.25 | WP_011226330 |
| HPOFIPAE_1 | 944678 | 946132 | STU_RS14650 | 0.0 | Capsule | Immune modulation | 98.69 | 100.00 | WP_011226049 |
| HPOFIPAE_1 | 944678 | 946132 | STR_RS05265 | 0.0 | Capsule | Immune modulation | 98.42 | 100.00 | WP_041827043 |
| HPOFIPAE_1 | 1254093 | 1254944 | rfbD | 0.0 | Capsule | Immune modulation | 98.12 | 100.00 | WP_014621820 |
| HPOFIPAE_1 | 944678 | 946132 | STER_RS05320 | 0.0 | Capsule | Immune modulation | 97.54 | 99.79 | WP_011681177 |
| HPOFIPAE_1 | 939646 | 940563 | STR_RS05240 | 0.0 | Capsule | Immune modulation | 97.17 | 95.62 | WP_041827042 |
| HPOFIPAE_1 | 943946 | 944677 | STU_RS14645 | 0.0 | Capsule | Immune modulation | 97.13 | 100.00 | WP_011226048 |
| HPOFIPAE_1 | 943946 | 944677 | STER_RS05315 | 0.0 | Capsule | Immune modulation | 97.00 | 100.00 | WP_011681176 |
| HPOFIPAE_1 | 943245 | 943937 | STR_RS05255 | 0.0 | Capsule | Immune modulation | 96.97 | 100.00 | WP_011227247 |
| HPOFIPAE_1 | 943245 | 943937 | STU_RS14640 | 0.0 | Capsule | Immune modulation | 96.97 | 100.00 | WP_011226047 |
| HPOFIPAE_1 | 943946 | 944677 | STR_RS05260 | 0.0 | Capsule | Immune modulation | 96.45 | 100.00 | WP_011227248 |
| HPOFIPAE_1 | 942498 | 943235 | STER_RS05305 | 0.0 | Capsule | Immune modulation | 96.21 | 99.60 | WP_011681174 |
| HPOFIPAE_1 | 942500 | 943235 | STR_RS05250 | 0.0 | Capsule | Immune modulation | 95.92 | 98.13 | WP_011227246 |
| HPOFIPAE_1 | 942498 | 943235 | STU_RS14635 | 0.0 | Capsule | Immune modulation | 95.80 | 99.60 | WP_011226046 |
| HPOFIPAE_1 | 941070 | 942437 | STU_RS14630 | 0.0 | Capsule | Immune modulation | 95.47 | 100.00 | WP_011226045 |
| HPOFIPAE_1 | 941072 | 942437 | STER_RS05300 | 0.0 | Capsule | Immune modulation | 94.29 | 99.85 | WP_011681173 |
| HPOFIPAE_1 | 943245 | 943937 | STER_RS05310 | 0.0 | Capsule | Immune modulation | 88.49 | 99.71 | WP_011681175 |
| HPOFIPAE_1 | 591276 | 592579 | eno | 0.0 | Streptococcal enolase | Exoenzyme | 88.17 | 99.54 | WP_000022832 |
| HPOFIPAE_1 | 1530247 | 1531257 | plr/gapA | 0.0 | Streptococcal plasmin receptor/GAPDH | Adherence | 87.02 | 99.51 | WP_002986042 |
| HPOFIPAE_1 | 136952 | 138235 | tig/ropA | 0.0 | Trigger factor | Stress survival | 80.58 | 99.77 | WP_000107753 |
| HPOFIPAE_1 | 1054007 | 1055053 | rfbB | 0.0 | Capsule | Immune modulation | 80.42 | 100.00 | WP_009659423 |
BLASTN v2.16.0 (Database: VFDB, Dec. 2024 release)
VirulenceFinder
| Query ID | Begin | End | Database | Virulence factor | Protein function | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
VirulenceFinder v2.0. 4 (Database: virulencefinder_db, Feb . 2024 release)
Pathogenic genes
PHI-base
| Query ID | qstart | qend | Gene name | e-value | Function | Identity | Coverage | Gene ID |
|---|---|---|---|---|---|---|---|---|
| HPOFIPAE_1 | 1094289 | 1095272 | ldh(Sp_1220) | 0.0 | L-lactate dehydrogenase | 94.82 | 100.00 | AAK75326 |
| HPOFIPAE_1 | 696674 | 697747 | MntE | 0.0 | manganese homeostasis | 94.41 | 99.72 | ABF32167 |
| HPOFIPAE_1 | 507648 | 508616 | spr0084 | 0.0 | pathogenitcity related | 93.19 | 98.48 | AAK98888 |
| HPOFIPAE_1 | 1409872 | 1412175 | pfl2(Sp_0459) | 0.0 | formate acetyltransferase | 93.10 | 99.22 | AAK74619 |
| HPOFIPAE_1 | 1157914 | 1159395 | SPD_0310 | 0.0 | UPF0371 protein SPD_0310 | 92.11 | 100.00 | ABJ54480 |
| HPOFIPAE_1 | 717196 | 719442 | metE | 0.0 | methionine biosynthesis enzymes | 91.86 | 100.00 | AAK74738 |
| HPOFIPAE_1 | 27122 | 28093 | prsA2 | 0.0 | ribose-phosphate pyrophosphokinase | 90.12 | 100.00 | ABF36968 |
| HPOFIPAE_1 | 1296115 | 1294964 | potA | 0.0 | ABC transporter ATP-binding protein-spermidine/putrescine transport | 89.32 | 99.74 | AAL00050 |
| HPOFIPAE_1 | 1268112 | 1266124 | uvrB | 0.0 | excinuclease ABC, B subunit | 88.99 | 100.00 | AE014259_2 |
| HPOFIPAE_1 | 1078094 | 1076364 | ptsI | 0.0 | phosphoenolpyruvate-protein phosphotransferase | 87.69 | 100.00 | AAK34199 |
| HPOFIPAE_1 | 1720760 | 1719282 | IMPDH | 0.0 | inosine-5'-monophosphate dehydrogenase | 87.63 | 100.00 | ADE32434 |
| HPOFIPAE_1 | 591276 | 592577 | Eno | 0.0 | enolase | 86.21 | 99.77 | ABP90468 |
| HPOFIPAE_1 | 1705564 | 1703672 | gidA | 0.0 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme | 86.05 | 98.90 | ABP91129 |
| HPOFIPAE_1 | 63239 | 64345 | recA | 0.0 | DNA recombination and repair | 84.91 | 95.36 | AAL00560 |
| HPOFIPAE_1 | 722367 | 720658 | PGM | 0.0 | phosphoglucomutase | 83.89 | 99.65 | ACH87041 |
| HPOFIPAE_1 | 1572227 | 1573237 | pdh | 0.0 | pyruvate dehydrogenase | 83.38 | 99.70 | ABP91006 |
| HPOFIPAE_1 | 868302 | 866941 | mnmE | 0.0 | central tRNA-modifying GTPase | 82.24 | 99.56 | ABP90420 |
| HPOFIPAE_1 | 1624239 | 1622347 | PepO | 0.0 | endopeptidase | 80.03 | 100.00 | ABF32980 |
| HPOFIPAE_1 | 576845 | 577735 | bglB | 1.24e-178 | putative phospho--glucosidase | 88.89 | 99.66 | AAK33487 |
| HPOFIPAE_1 | 781713 | 780775 | SP_0676 | 7.68e-168 | transcription facot | 81.47 | 97.20 | AAK74821 |
| HPOFIPAE_1 | 719634 | 720491 | metF | 8.08e-165 | methionine biosynthesis enzymes | 86.36 | 99.31 | AAK74739 |
| HPOFIPAE_1 | 982959 | 982255 | covR | 3.27e-130 | responder protein | 84.68 | 100.00 | AAK71319 |
| HPOFIPAE_1 | 1138951 | 1138280 | rr01 | 1.91e-125 | response regulator | 84.82 | 99.56 | CAB54566 |
| HPOFIPAE_1 | 726320 | 726988 | CiaR | 1.84e-120 | two-component response regulator | 86.10 | 99.55 | AAK74935 |
| HPOFIPAE_1 | 982959 | 982255 | walR | 2.35e-120 | DNA-binding response regulator | 80.85 | 100.00 | ANC99504 |
| HPOFIPAE_1 | 726320 | 726991 | ciaR | 2.28e-118 | two component system response regulator | 83.93 | 99.12 | AIK75708 |
| HPOFIPAE_1 | 293343 | 294029 | CovR | 9.40e-118 | serves to repress GAS virulence factor-encoding genes | 80.79 | 100.00 | ACE75886 |
| HPOFIPAE_1 | 64529 | 64903 | SpxA2 | 1.08e-69 | transcriptional regulator | 91.20 | 94.70 | ERL21461 |
| HPOFIPAE_1 | 879660 | 880061 | SpxA1 | 3.52e-66 | transcriptional regulator | 80.60 | 100.00 | ERL19273 |
| HPOFIPAE_1 | 138393 | 138893 | RopE (M5005_Spy_1611) | 4.60e-75 | probable DNA-directed RNA polymerase subunit delta | 81.44 | 87.43 | AAK34603 |
| HPOFIPAE_1 | 1409872 | 1412169 | PFL (B9H01_RS01125) | 0.0 | formate C-acetyltransferase | 83.07 | 98.08 | MYN69560 |
| HPOFIPAE_1 | 1609781 | 1608762 | ilvC (SPD_0406) | 0.0 | ketol-acid reductoisomerase (NADP(+)) | 96.47 | 100.00 | ABJ55451 |
BLASTX v2.16.0 (Database: PHI base v4.16, May. 2024 release)
Plasmid
PlasmidFinder
| Query ID | Begin | End | Plasmid | Query / Template | Identity | Accession no. |
|---|---|---|---|---|---|---|
| No hit found | ||||||
PlasmidFinder v 2.1.6 (Database: plasmidfinder_db v 2.2.0 , Nov. 2024 release)
PlasmidHunter
| Query ID | Prediction | Chromosome | Plasmid |
|---|---|---|---|
| HPOFIPAE_1 | 0.0 | 1.0 | 0.0 |
PlasmidHunter v 1.4.5 (Database: May. 2024 release)
Prophage
Phigaro
| Query ID | Begin | End | Transposable | Taxonomy | pVOGs |
|---|---|---|---|---|---|
| No hit found | |||||
Phigaro v2.4.0 (Database: Jan. 2024 release)