Probiotic potential risk score
| ARGs | VFs | PGs | PPRS |
|---|---|---|---|
| 0 | 22 | 28 | 35.61 |
PPRS is classified as low-risk (≤4), medium-risk (4-6), and high-risk (≥6).
Antibiotic resistance genes
Comprehensive Antibiotic Resistance Database (CARD)
| Query ID | Begin | End | ARO name | ARO accession | CARD name | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
RGI v6.0.3 (Database: CARD Variants v4.0.2, Nov. 2023 release)
ResFinder
| Query ID | Begin | End | Resistance gene | Phenotype | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|
| No hit found | |||||||
ResFinder v4.6.0 (Database: resfinder_db, Aug. 2024 release)
AMRFinderPlus
| Query ID | Begin | End | Gene symbol | Sequence name | Method | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
AMRFinderPlus v4.0.3 (Database: Oct. 2024 release)
Virulence factors
Virulence Factor Database (VFDB)
| Query ID | qstart | qend | Gene name | e-value | VF name | VF category | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|---|
| EHEIDDEP_1 | 1300444 | 1301703 | STER_RS07100 | 0.0 | Capsule | Immune modulation | 99.76 | 100.00 | WP_011681445 |
| EHEIDDEP_1 | 43634 | 44473 | cbpD | 0.0 | Autolysin | Exoenzyme | 99.52 | 100.00 | WP_011226733 |
| EHEIDDEP_1 | 1298484 | 1299452 | STER_RS07090 | 0.0 | Capsule | Immune modulation | 99.48 | 100.00 | WP_011681443 |
| EHEIDDEP_1 | 1074144 | 1075013 | rfbA | 0.0 | Capsule | Immune modulation | 99.42 | 100.00 | WP_011681286 |
| EHEIDDEP_1 | 1073551 | 1074144 | STR_RS05880 | 0.0 | Capsule | Immune modulation | 99.33 | 100.00 | WP_011226149 |
| EHEIDDEP_1 | 1299470 | 1300447 | STER_RS07095 | 0.0 | Capsule | Immune modulation | 99.28 | 100.00 | WP_011681444 |
| EHEIDDEP_1 | 1028730 | 1029520 | cshA | 0.0 | Cell surface hydrophobicity proteins | Adherence | 99.24 | 100.00 | - |
| EHEIDDEP_1 | 846997 | 848655 | fbp54 | 0.0 | FBPs | Adherence | 99.22 | 100.00 | WP_011227179 |
| EHEIDDEP_1 | 1073551 | 1074144 | STER_RS06030 | 0.0 | Capsule | Immune modulation | 99.16 | 100.00 | WP_011226149 |
| EHEIDDEP_1 | 1073551 | 1074144 | STU_RS15260 | 0.0 | Capsule | Immune modulation | 99.16 | 100.00 | WP_011226149 |
| EHEIDDEP_1 | 962133 | 962864 | STER_RS05315 | 0.0 | Capsule | Immune modulation | 98.91 | 100.00 | WP_011681176 |
| EHEIDDEP_1 | 1108922 | 1109683 | srtA | 0.0 | Sortase A | Exoenzyme | 98.82 | 100.00 | - |
| EHEIDDEP_1 | 962133 | 962864 | STU_RS14645 | 0.0 | Capsule | Immune modulation | 98.63 | 100.00 | WP_011226048 |
| EHEIDDEP_1 | 962133 | 962864 | STR_RS05260 | 0.0 | Capsule | Immune modulation | 98.50 | 100.00 | WP_011227248 |
| EHEIDDEP_1 | 962865 | 964325 | STER_RS05320 | 0.0 | Capsule | Immune modulation | 98.22 | 100.00 | WP_011681177 |
| EHEIDDEP_1 | 1297767 | 1298482 | STER_RS07085 | 0.0 | Capsule | Immune modulation | 98.18 | 99.86 | WP_011681442 |
| EHEIDDEP_1 | 952116 | 953531 | STER_RS05250 | 0.0 | Capsule | Immune modulation | 97.88 | 100.00 | WP_011681165 |
| EHEIDDEP_1 | 961432 | 962124 | STR_RS05255 | 0.0 | Capsule | Immune modulation | 97.83 | 100.00 | WP_011227247 |
| EHEIDDEP_1 | 961432 | 962124 | STU_RS14640 | 0.0 | Capsule | Immune modulation | 97.83 | 100.00 | WP_011226047 |
| EHEIDDEP_1 | 1296645 | 1297421 | STER_RS07075 | 0.0 | Capsule | Immune modulation | 97.81 | 100.00 | WP_011681440 |
| EHEIDDEP_1 | 960684 | 961422 | STER_RS05305 | 0.0 | Capsule | Immune modulation | 97.56 | 99.73 | WP_011681174 |
| EHEIDDEP_1 | 1301822 | 1302673 | rfbD | 0.0 | Capsule | Immune modulation | 97.30 | 100.00 | WP_014621820 |
| EHEIDDEP_1 | 962865 | 964325 | STU_RS14650 | 0.0 | Capsule | Immune modulation | 97.19 | 100.21 | WP_011226049 |
| EHEIDDEP_1 | 960684 | 961422 | STU_RS14635 | 0.0 | Capsule | Immune modulation | 96.89 | 99.73 | WP_011226046 |
| EHEIDDEP_1 | 960687 | 961422 | STR_RS05250 | 0.0 | Capsule | Immune modulation | 96.74 | 98.13 | WP_011227246 |
| EHEIDDEP_1 | 962865 | 964325 | STR_RS05265 | 0.0 | Capsule | Immune modulation | 96.37 | 100.21 | WP_041827043 |
| EHEIDDEP_1 | 959257 | 960624 | STU_RS14630 | 0.0 | Capsule | Immune modulation | 94.88 | 100.00 | WP_011226045 |
| EHEIDDEP_1 | 959259 | 960624 | STER_RS05300 | 0.0 | Capsule | Immune modulation | 94.29 | 99.85 | WP_011681173 |
| EHEIDDEP_1 | 961432 | 962124 | STER_RS05310 | 0.0 | Capsule | Immune modulation | 90.04 | 100.00 | WP_011681175 |
| EHEIDDEP_1 | 592558 | 593861 | eno | 0.0 | Streptococcal enolase | Exoenzyme | 88.09 | 99.54 | WP_000022832 |
| EHEIDDEP_1 | 1590612 | 1591622 | plr/gapA | 0.0 | Streptococcal plasmin receptor/GAPDH | Adherence | 86.92 | 99.51 | WP_002986042 |
| EHEIDDEP_1 | 1072075 | 1073121 | rfbB | 0.0 | Capsule | Immune modulation | 80.61 | 100.00 | WP_009659423 |
| EHEIDDEP_1 | 147088 | 148371 | tig/ropA | 0.0 | Trigger factor | Stress survival | 80.19 | 99.77 | WP_000107753 |
BLASTN v2.16.0 (Database: VFDB, Dec. 2024 release)
VirulenceFinder
| Query ID | Begin | End | Database | Virulence factor | Protein function | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
VirulenceFinder v2.0. 4 (Database: virulencefinder_db, Feb . 2024 release)
Pathogenic genes
PHI-base
| Query ID | qstart | qend | Gene name | e-value | Function | Identity | Coverage | Gene ID |
|---|---|---|---|---|---|---|---|---|
| EHEIDDEP_1 | 1112370 | 1113353 | ldh(Sp_1220) | 0.0 | L-lactate dehydrogenase | 94.82 | 100.00 | AAK75326 |
| EHEIDDEP_1 | 699138 | 700211 | MntE | 0.0 | manganese homeostasis | 94.41 | 99.72 | ABF32167 |
| EHEIDDEP_1 | 510598 | 511566 | spr0084 | 0.0 | pathogenitcity related | 93.19 | 98.48 | AAK98888 |
| EHEIDDEP_1 | 1469285 | 1471588 | pfl2(Sp_0459) | 0.0 | formate acetyltransferase | 92.97 | 99.22 | AAK74619 |
| EHEIDDEP_1 | 729590 | 731836 | metE | 0.0 | methionine biosynthesis enzymes | 91.99 | 100.00 | AAK74738 |
| EHEIDDEP_1 | 1196952 | 1198433 | SPD_0310 | 0.0 | UPF0371 protein SPD_0310 | 91.90 | 100.00 | ABJ54480 |
| EHEIDDEP_1 | 64134 | 65132 | recA | 0.0 | DNA recombination and repair | 91.29 | 85.82 | AAL00560 |
| EHEIDDEP_1 | 27152 | 28123 | prsA2 | 0.0 | ribose-phosphate pyrophosphokinase | 90.12 | 100.00 | ABF36968 |
| EHEIDDEP_1 | 1343900 | 1342749 | potA | 0.0 | ABC transporter ATP-binding protein-spermidine/putrescine transport | 89.06 | 99.74 | AAL00050 |
| EHEIDDEP_1 | 1315922 | 1313934 | uvrB | 0.0 | excinuclease ABC, B subunit | 88.99 | 100.00 | AE014259_2 |
| EHEIDDEP_1 | 1096175 | 1094445 | ptsI | 0.0 | phosphoenolpyruvate-protein phosphotransferase | 87.69 | 100.00 | AAK34199 |
| EHEIDDEP_1 | 1790335 | 1788857 | IMPDH | 0.0 | inosine-5'-monophosphate dehydrogenase | 87.63 | 100.00 | ADE32434 |
| EHEIDDEP_1 | 1775601 | 1773709 | gidA | 0.0 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme | 86.05 | 98.90 | ABP91129 |
| EHEIDDEP_1 | 592558 | 593859 | Eno | 0.0 | enolase | 85.98 | 99.77 | ABP90468 |
| EHEIDDEP_1 | 734761 | 733052 | PGM | 0.0 | phosphoglucomutase | 83.89 | 99.65 | ACH87041 |
| EHEIDDEP_1 | 1632591 | 1633601 | pdh | 0.0 | pyruvate dehydrogenase | 83.38 | 99.70 | ABP91006 |
| EHEIDDEP_1 | 872536 | 871175 | mnmE | 0.0 | central tRNA-modifying GTPase | 82.24 | 99.56 | ABP90420 |
| EHEIDDEP_1 | 578131 | 579021 | bglB | 1.29e-177 | putative phospho--glucosidase | 88.55 | 99.66 | AAK33487 |
| EHEIDDEP_1 | 792621 | 791686 | SP_0676 | 7.18e-168 | transcription facot | 81.73 | 96.89 | AAK74821 |
| EHEIDDEP_1 | 732028 | 732885 | metF | 4.52e-164 | methionine biosynthesis enzymes | 86.01 | 99.31 | AAK74739 |
| EHEIDDEP_1 | 1001043 | 1000339 | covR | 4.26e-131 | responder protein | 85.53 | 100.00 | AAK71319 |
| EHEIDDEP_1 | 1168837 | 1168166 | rr01 | 3.87e-125 | response regulator | 84.38 | 99.56 | CAB54566 |
| EHEIDDEP_1 | 1001043 | 1000339 | walR | 1.79e-121 | DNA-binding response regulator | 82.13 | 100.00 | ANC99504 |
| EHEIDDEP_1 | 738715 | 739383 | CiaR | 9.15e-118 | two-component response regulator | 84.75 | 99.55 | AAK74935 |
| EHEIDDEP_1 | 295941 | 296627 | CovR | 1.21e-117 | serves to repress GAS virulence factor-encoding genes | 80.79 | 100.00 | ACE75886 |
| EHEIDDEP_1 | 738715 | 739386 | ciaR | 9.92e-116 | two component system response regulator | 82.59 | 99.12 | AIK75708 |
| EHEIDDEP_1 | 65408 | 65782 | SpxA2 | 1.12e-69 | transcriptional regulator | 91.20 | 94.70 | ERL21461 |
| EHEIDDEP_1 | 883895 | 884296 | SpxA1 | 3.66e-66 | transcriptional regulator | 80.60 | 100.00 | ERL19273 |
| EHEIDDEP_1 | 148529 | 149029 | RopE (M5005_Spy_1611) | 4.78e-75 | probable DNA-directed RNA polymerase subunit delta | 81.44 | 87.43 | AAK34603 |
| EHEIDDEP_1 | 1469285 | 1471582 | PFL (B9H01_RS01125) | 0.0 | formate C-acetyltransferase | 82.94 | 98.08 | MYN69560 |
| EHEIDDEP_1 | 1668453 | 1667434 | ilvC (SPD_0406) | 0.0 | ketol-acid reductoisomerase (NADP(+)) | 96.18 | 100.00 | ABJ55451 |
BLASTX v2.16.0 (Database: PHI base v4.16, May. 2024 release)
Plasmid
PlasmidFinder
| Query ID | Begin | End | Plasmid | Query / Template | Identity | Accession no. |
|---|---|---|---|---|---|---|
| No hit found | ||||||
PlasmidFinder v 2.1.6 (Database: plasmidfinder_db v 2.2.0 , Nov. 2024 release)
PlasmidHunter
| Query ID | Prediction | Chromosome | Plasmid |
|---|---|---|---|
| EHEIDDEP_1 | 0.0 | 1.0 | 0.0 |
PlasmidHunter v 1.4.5 (Database: May. 2024 release)
Prophage
Phigaro
| Query ID | Begin | End | Transposable | Taxonomy | pVOGs |
|---|---|---|---|---|---|
| No hit found | |||||
Phigaro v2.4.0 (Database: Jan. 2024 release)