Probiotic potential risk score
| ARGs | VFs | PGs | PPRS |
|---|---|---|---|
| 0 | 25 | 29 | 38.29 |
PPRS is classified as low-risk (≤4), medium-risk (4-6), and high-risk (≥6).
Antibiotic resistance genes
Comprehensive Antibiotic Resistance Database (CARD)
| Query ID | Begin | End | ARO name | ARO accession | CARD name | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
RGI v6.0.3 (Database: CARD Variants v4.0.2, Nov. 2023 release)
ResFinder
| Query ID | Begin | End | Resistance gene | Phenotype | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|
| No hit found | |||||||
ResFinder v4.6.0 (Database: resfinder_db, Aug. 2024 release)
AMRFinderPlus
| Query ID | Begin | End | Gene symbol | Sequence name | Method | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
AMRFinderPlus v4.0.3 (Database: Oct. 2024 release)
Virulence factors
Virulence Factor Database (VFDB)
| Query ID | qstart | qend | Gene name | e-value | VF name | VF category | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|---|
| BHPHAEOG_1 | 1356920 | 1357726 | STR_RS06900 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011227429 |
| BHPHAEOG_1 | 1357726 | 1358667 | STR_RS06905 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011227430 |
| BHPHAEOG_1 | 1352211 | 1353956 | STR_RS06885 | 0.0 | Capsule | Immune modulation | 99.94 | 100.00 | WP_011227426 |
| BHPHAEOG_1 | 1364731 | 1365582 | rfbD | 0.0 | Capsule | Immune modulation | 99.88 | 100.00 | WP_014621820 |
| BHPHAEOG_1 | 1358664 | 1359812 | STR_RS06910 | 0.0 | Capsule | Immune modulation | 99.83 | 100.00 | WP_011227431 |
| BHPHAEOG_1 | 1354060 | 1355700 | STER_RS07050 | 0.0 | Capsule | Immune modulation | 99.82 | 96.47 | WP_041827753 |
| BHPHAEOG_1 | 43676 | 44515 | cbpD | 0.0 | Autolysin | Exoenzyme | 99.76 | 100.00 | WP_011226733 |
| BHPHAEOG_1 | 1355718 | 1356920 | STR_RS06895 | 0.0 | Capsule | Immune modulation | 99.75 | 100.00 | WP_011227428 |
| BHPHAEOG_1 | 1120925 | 1121518 | STR_RS05880 | 0.0 | Capsule | Immune modulation | 99.66 | 100.00 | WP_011226149 |
| BHPHAEOG_1 | 1354060 | 1355700 | STR_RS06890 | 0.0 | Capsule | Immune modulation | 99.63 | 96.47 | WP_041827077 |
| BHPHAEOG_1 | 860552 | 862210 | fbp54 | 0.0 | FBPs | Adherence | 99.58 | 100.00 | WP_011227179 |
| BHPHAEOG_1 | 1120925 | 1121518 | STER_RS06030 | 0.0 | Capsule | Immune modulation | 99.50 | 100.00 | WP_011226149 |
| BHPHAEOG_1 | 1355718 | 1356920 | STER_RS07055 | 0.0 | Capsule | Immune modulation | 99.50 | 100.00 | WP_011681436 |
| BHPHAEOG_1 | 1356920 | 1357726 | STER_RS07060 | 0.0 | Capsule | Immune modulation | 99.50 | 100.00 | WP_011681437 |
| BHPHAEOG_1 | 1120925 | 1121518 | STU_RS15260 | 0.0 | Capsule | Immune modulation | 99.50 | 100.00 | WP_011226149 |
| BHPHAEOG_1 | 1156285 | 1157046 | srtA | 0.0 | Sortase A | Exoenzyme | 99.47 | 100.00 | - |
| BHPHAEOG_1 | 1357726 | 1358667 | STER_RS07065 | 0.0 | Capsule | Immune modulation | 99.47 | 100.00 | WP_011681438 |
| BHPHAEOG_1 | 1121518 | 1122387 | rfbA | 0.0 | Capsule | Immune modulation | 99.31 | 100.00 | WP_011681286 |
| BHPHAEOG_1 | 1358664 | 1359812 | STER_RS07070 | 0.0 | Capsule | Immune modulation | 99.04 | 100.00 | WP_011681439 |
| BHPHAEOG_1 | 1008276 | 1009007 | STU_RS14645 | 0.0 | Capsule | Immune modulation | 98.91 | 100.00 | WP_011226048 |
| BHPHAEOG_1 | 998276 | 999691 | STER_RS05250 | 0.0 | Capsule | Immune modulation | 98.87 | 100.00 | WP_011681165 |
| BHPHAEOG_1 | 1074791 | 1075581 | cshA | 0.0 | Cell surface hydrophobicity proteins | Adherence | 98.86 | 100.00 | - |
| BHPHAEOG_1 | 1008276 | 1009007 | STR_RS05260 | 0.0 | Capsule | Immune modulation | 98.77 | 100.00 | WP_011227248 |
| BHPHAEOG_1 | 1008276 | 1009007 | STER_RS05315 | 0.0 | Capsule | Immune modulation | 98.63 | 100.00 | WP_011681176 |
| BHPHAEOG_1 | 1352211 | 1353956 | STER_RS07045 | 0.0 | Capsule | Immune modulation | 98.28 | 100.00 | WP_011681434 |
| BHPHAEOG_1 | 1006825 | 1007565 | STU_RS14635 | 0.0 | Capsule | Immune modulation | 98.11 | 100.00 | WP_011226046 |
| BHPHAEOG_1 | 1363351 | 1364610 | STER_RS07100 | 0.0 | Capsule | Immune modulation | 97.78 | 100.00 | WP_011681445 |
| BHPHAEOG_1 | 1009008 | 1010468 | STER_RS05320 | 0.0 | Capsule | Immune modulation | 97.74 | 100.00 | WP_011681177 |
| BHPHAEOG_1 | 1006825 | 1007565 | STER_RS05305 | 0.0 | Capsule | Immune modulation | 97.44 | 100.00 | WP_011681174 |
| BHPHAEOG_1 | 1006830 | 1007565 | STR_RS05250 | 0.0 | Capsule | Immune modulation | 97.15 | 98.13 | WP_011227246 |
| BHPHAEOG_1 | 1009008 | 1010468 | STU_RS14650 | 0.0 | Capsule | Immune modulation | 96.99 | 100.21 | WP_011226049 |
| BHPHAEOG_1 | 1009008 | 1010468 | STR_RS05265 | 0.0 | Capsule | Immune modulation | 96.85 | 100.21 | WP_041827043 |
| BHPHAEOG_1 | 1007575 | 1008267 | STR_RS05255 | 0.0 | Capsule | Immune modulation | 95.67 | 100.00 | WP_011227247 |
| BHPHAEOG_1 | 1007575 | 1008267 | STU_RS14640 | 0.0 | Capsule | Immune modulation | 95.67 | 100.00 | WP_011226047 |
| BHPHAEOG_1 | 1005400 | 1006767 | STU_RS14630 | 0.0 | Capsule | Immune modulation | 94.96 | 100.00 | WP_011226045 |
| BHPHAEOG_1 | 1005402 | 1006767 | STER_RS05300 | 0.0 | Capsule | Immune modulation | 94.37 | 99.78 | WP_011681173 |
| BHPHAEOG_1 | 1007575 | 1008267 | STER_RS05310 | 0.0 | Capsule | Immune modulation | 89.75 | 100.00 | WP_011681175 |
| BHPHAEOG_1 | 613944 | 615247 | eno | 0.0 | Streptococcal enolase | Exoenzyme | 88.02 | 99.54 | WP_000022832 |
| BHPHAEOG_1 | 1643521 | 1644531 | plr/gapA | 0.0 | Streptococcal plasmin receptor/GAPDH | Adherence | 86.92 | 99.51 | WP_002986042 |
| BHPHAEOG_1 | 1356920 | 1357726 | SGO_RS05020 | 0.0 | Capsule | Immune modulation | 82.90 | 100.00 | WP_012000440 |
| BHPHAEOG_1 | 148987 | 150270 | tig/ropA | 0.0 | Trigger factor | Stress survival | 80.73 | 99.77 | WP_000107753 |
| BHPHAEOG_1 | 1119450 | 1120496 | rfbB | 0.0 | Capsule | Immune modulation | 80.71 | 100.00 | WP_009659423 |
| BHPHAEOG_1 | 1362656 | 1363354 | STER_RS07095 | 6.47e-154 | Capsule | Immune modulation | 81.29 | 70.35 | WP_011681444 |
| BHPHAEOG_1 | 1361836 | 1362302 | STER_RS07085 | 0.0 | Capsule | Immune modulation | 94.02 | 65.13 | WP_011681442 |
| BHPHAEOG_1 | 1356183 | 1356920 | SGO_RS05025 | 0.0 | Capsule | Immune modulation | 85.09 | 60.29 | WP_012000441 |
BLASTN v2.16.0 (Database: VFDB, Dec. 2024 release)
VirulenceFinder
| Query ID | Begin | End | Database | Virulence factor | Protein function | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
VirulenceFinder v2.0. 4 (Database: virulencefinder_db, Feb . 2024 release)
Pathogenic genes
PHI-base
| Query ID | qstart | qend | Gene name | e-value | Function | Identity | Coverage | Gene ID |
|---|---|---|---|---|---|---|---|---|
| BHPHAEOG_1 | 1159733 | 1160716 | ldh(Sp_1220) | 0.0 | L-lactate dehydrogenase | 94.82 | 100.00 | AAK75326 |
| BHPHAEOG_1 | 716717 | 717790 | MntE | 0.0 | manganese homeostasis | 94.41 | 99.72 | ABF32167 |
| BHPHAEOG_1 | 1520880 | 1523183 | pfl2(Sp_0459) | 0.0 | formate acetyltransferase | 92.97 | 99.22 | AAK74619 |
| BHPHAEOG_1 | 531669 | 532637 | spr0084 | 0.0 | pathogenitcity related | 92.88 | 98.48 | AAK98888 |
| BHPHAEOG_1 | 1251382 | 1252863 | SPD_0310 | 0.0 | UPF0371 protein SPD_0310 | 92.11 | 100.00 | ABJ54480 |
| BHPHAEOG_1 | 737240 | 739486 | metE | 0.0 | methionine biosynthesis enzymes | 91.99 | 100.00 | AAK74738 |
| BHPHAEOG_1 | 64625 | 65623 | recA | 0.0 | DNA recombination and repair | 91.29 | 85.82 | AAL00560 |
| BHPHAEOG_1 | 27194 | 28165 | prsA2 | 0.0 | ribose-phosphate pyrophosphokinase | 90.12 | 100.00 | ABF36968 |
| BHPHAEOG_1 | 1405379 | 1404228 | potA | 0.0 | ABC transporter ATP-binding protein-spermidine/putrescine transport | 89.06 | 99.74 | AAL00050 |
| BHPHAEOG_1 | 1377382 | 1375394 | uvrB | 0.0 | excinuclease ABC, B subunit | 88.99 | 100.00 | AE014259_2 |
| BHPHAEOG_1 | 1143538 | 1141808 | ptsI | 0.0 | phosphoenolpyruvate-protein phosphotransferase | 87.69 | 100.00 | AAK34199 |
| BHPHAEOG_1 | 1836154 | 1834676 | IMPDH | 0.0 | inosine-5'-monophosphate dehydrogenase | 87.42 | 100.00 | ADE32434 |
| BHPHAEOG_1 | 613944 | 615245 | Eno | 0.0 | enolase | 86.21 | 99.77 | ABP90468 |
| BHPHAEOG_1 | 1820958 | 1819066 | gidA | 0.0 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme | 85.89 | 98.90 | ABP91129 |
| BHPHAEOG_1 | 742411 | 740702 | PGM | 0.0 | phosphoglucomutase | 83.89 | 99.65 | ACH87041 |
| BHPHAEOG_1 | 1686894 | 1687904 | pdh | 0.0 | pyruvate dehydrogenase | 83.09 | 99.70 | ABP91006 |
| BHPHAEOG_1 | 897739 | 896378 | mnmE | 0.0 | central tRNA-modifying GTPase | 82.02 | 99.56 | ABP90420 |
| BHPHAEOG_1 | 1738910 | 1737018 | PepO | 0.0 | endopeptidase | 80.19 | 100.00 | ABF32980 |
| BHPHAEOG_1 | 599503 | 600393 | bglB | 8.91e-178 | putative phospho--glucosidase | 88.22 | 99.66 | AAK33487 |
| BHPHAEOG_1 | 800349 | 799411 | SP_0676 | 8.19e-168 | transcription facot | 81.47 | 97.20 | AAK74821 |
| BHPHAEOG_1 | 739678 | 740535 | metF | 8.62e-165 | methionine biosynthesis enzymes | 86.36 | 99.31 | AAK74739 |
| BHPHAEOG_1 | 1047082 | 1046378 | covR | 3.49e-130 | responder protein | 84.68 | 100.00 | AAK71319 |
| BHPHAEOG_1 | 1217651 | 1216980 | rr01 | 4.12e-126 | response regulator | 84.82 | 99.56 | CAB54566 |
| BHPHAEOG_1 | 1047082 | 1046378 | walR | 2.50e-120 | DNA-binding response regulator | 80.85 | 100.00 | ANC99504 |
| BHPHAEOG_1 | 305441 | 306127 | CovR | 1.00e-117 | serves to repress GAS virulence factor-encoding genes | 80.79 | 100.00 | ACE75886 |
| BHPHAEOG_1 | 746366 | 747034 | CiaR | 2.01e-117 | two-component response regulator | 84.31 | 99.55 | AAK74935 |
| BHPHAEOG_1 | 746366 | 747037 | ciaR | 1.98e-115 | two component system response regulator | 82.14 | 99.12 | AIK75708 |
| BHPHAEOG_1 | 65899 | 66294 | SpxA2 | 3.69e-74 | transcriptional regulator | 90.91 | 100.00 | ERL21461 |
| BHPHAEOG_1 | 909099 | 909500 | SpxA1 | 3.75e-66 | transcriptional regulator | 80.60 | 100.00 | ERL19273 |
| BHPHAEOG_1 | 150428 | 150928 | RopE (M5005_Spy_1611) | 4.91e-75 | probable DNA-directed RNA polymerase subunit delta | 81.44 | 87.43 | AAK34603 |
| BHPHAEOG_1 | 1520880 | 1523177 | PFL (B9H01_RS01125) | 0.0 | formate C-acetyltransferase | 82.94 | 98.08 | MYN69560 |
| BHPHAEOG_1 | 1724439 | 1723420 | ilvC (SPD_0406) | 0.0 | ketol-acid reductoisomerase (NADP(+)) | 96.47 | 100.00 | ABJ55451 |
BLASTX v2.16.0 (Database: PHI base v4.16, May. 2024 release)
Plasmid
PlasmidFinder
| Query ID | Begin | End | Plasmid | Query / Template | Identity | Accession no. |
|---|---|---|---|---|---|---|
| No hit found | ||||||
PlasmidFinder v 2.1.6 (Database: plasmidfinder_db v 2.2.0 , Nov. 2024 release)
PlasmidHunter
| Query ID | Prediction | Chromosome | Plasmid |
|---|---|---|---|
| BHPHAEOG_1 | 0.0 | 1.0 | 0.0 |
PlasmidHunter v 1.4.5 (Database: May. 2024 release)
Prophage
Phigaro
| Query ID | Begin | End | Transposable | Taxonomy | pVOGs |
|---|---|---|---|---|---|
| No hit found | |||||
Phigaro v2.4.0 (Database: Jan. 2024 release)