Probiotic potential risk score
| ARGs | VFs | PGs | PPRS |
|---|---|---|---|
| 0 | 22 | 29 | 36.40 |
PPRS is classified as low-risk (≤4), medium-risk (4-6), and high-risk (≥6).
Antibiotic resistance genes
Comprehensive Antibiotic Resistance Database (CARD)
| Query ID | Begin | End | ARO name | ARO accession | CARD name | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
RGI v6.0.3 (Database: CARD Variants v4.0.2, Nov. 2023 release)
ResFinder
| Query ID | Begin | End | Resistance gene | Phenotype | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|
| No hit found | |||||||
ResFinder v4.6.0 (Database: resfinder_db, Aug. 2024 release)
AMRFinderPlus
| Query ID | Begin | End | Gene symbol | Sequence name | Method | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
AMRFinderPlus v4.0.3 (Database: Oct. 2024 release)
Virulence factors
Virulence Factor Database (VFDB)
| Query ID | qstart | qend | Gene name | e-value | VF name | VF category | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|---|
| CICCLELB_1 | 1119341 | 1120210 | rfbA | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011681286 |
| CICCLELB_1 | 1118748 | 1119341 | STER_RS06030 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011226149 |
| CICCLELB_1 | 1343678 | 1344937 | STER_RS07100 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011681445 |
| CICCLELB_1 | 1118748 | 1119341 | STR_RS05880 | 0.0 | Capsule | Immune modulation | 99.83 | 100.00 | WP_011226149 |
| CICCLELB_1 | 1118748 | 1119341 | STU_RS15260 | 0.0 | Capsule | Immune modulation | 99.66 | 100.00 | WP_011226149 |
| CICCLELB_1 | 1342705 | 1343681 | STER_RS07095 | 0.0 | Capsule | Immune modulation | 99.59 | 99.90 | WP_011681444 |
| CICCLELB_1 | 871145 | 872803 | fbp54 | 0.0 | FBPs | Adherence | 99.58 | 100.00 | WP_011227179 |
| CICCLELB_1 | 43683 | 44522 | cbpD | 0.0 | Autolysin | Exoenzyme | 99.52 | 100.00 | WP_011226733 |
| CICCLELB_1 | 1341719 | 1342687 | STER_RS07090 | 0.0 | Capsule | Immune modulation | 99.28 | 100.00 | WP_011681443 |
| CICCLELB_1 | 1155534 | 1156295 | srtA | 0.0 | Sortase A | Exoenzyme | 99.21 | 100.00 | - |
| CICCLELB_1 | 981501 | 982232 | STU_RS14645 | 0.0 | Capsule | Immune modulation | 99.18 | 100.00 | WP_011226048 |
| CICCLELB_1 | 981501 | 982232 | STR_RS05260 | 0.0 | Capsule | Immune modulation | 99.04 | 100.00 | WP_011227248 |
| CICCLELB_1 | 981501 | 982232 | STER_RS05315 | 0.0 | Capsule | Immune modulation | 98.91 | 100.00 | WP_011681176 |
| CICCLELB_1 | 1341002 | 1341717 | STER_RS07085 | 0.0 | Capsule | Immune modulation | 98.32 | 99.86 | WP_011681442 |
| CICCLELB_1 | 1339886 | 1340656 | STER_RS07075 | 0.0 | Capsule | Immune modulation | 97.92 | 99.23 | WP_011681440 |
| CICCLELB_1 | 971532 | 972947 | STER_RS05250 | 0.0 | Capsule | Immune modulation | 97.88 | 100.00 | WP_011681165 |
| CICCLELB_1 | 982233 | 983693 | STER_RS05320 | 0.0 | Capsule | Immune modulation | 97.67 | 100.00 | WP_011681177 |
| CICCLELB_1 | 1061088 | 1061886 | cshA | 0.0 | Cell surface hydrophobicity proteins | Adherence | 97.62 | 100.88 | - |
| CICCLELB_1 | 1345056 | 1345907 | rfbD | 0.0 | Capsule | Immune modulation | 97.30 | 100.00 | WP_014621820 |
| CICCLELB_1 | 980800 | 981492 | STU_RS14640 | 0.0 | Capsule | Immune modulation | 97.11 | 100.00 | WP_011226047 |
| CICCLELB_1 | 980800 | 981492 | STR_RS05255 | 0.0 | Capsule | Immune modulation | 96.97 | 100.00 | WP_011227247 |
| CICCLELB_1 | 982233 | 983693 | STU_RS14650 | 0.0 | Capsule | Immune modulation | 96.65 | 100.21 | WP_011226049 |
| CICCLELB_1 | 982233 | 983693 | STR_RS05265 | 0.0 | Capsule | Immune modulation | 95.96 | 100.21 | WP_041827043 |
| CICCLELB_1 | 978610 | 979975 | STER_RS05300 | 0.0 | Capsule | Immune modulation | 95.46 | 99.85 | WP_011681173 |
| CICCLELB_1 | 978608 | 979975 | STU_RS14630 | 0.0 | Capsule | Immune modulation | 94.08 | 100.00 | WP_011226045 |
| CICCLELB_1 | 980032 | 980790 | STER_RS05305 | 0.0 | Capsule | Immune modulation | 93.41 | 100.94 | WP_011681174 |
| CICCLELB_1 | 980032 | 980790 | STU_RS14635 | 0.0 | Capsule | Immune modulation | 93.02 | 100.94 | WP_011226046 |
| CICCLELB_1 | 980037 | 980790 | STR_RS05250 | 0.0 | Capsule | Immune modulation | 92.71 | 99.07 | WP_011227246 |
| CICCLELB_1 | 980800 | 981492 | STER_RS05310 | 0.0 | Capsule | Immune modulation | 90.06 | 99.86 | WP_011681175 |
| CICCLELB_1 | 616067 | 617370 | eno | 0.0 | Streptococcal enolase | Exoenzyme | 88.10 | 99.46 | WP_000022832 |
| CICCLELB_1 | 1631624 | 1632634 | plr/gapA | 0.0 | Streptococcal plasmin receptor/GAPDH | Adherence | 86.54 | 99.41 | WP_002986042 |
| CICCLELB_1 | 1117273 | 1118319 | rfbB | 0.0 | Capsule | Immune modulation | 80.61 | 100.00 | WP_009659423 |
| CICCLELB_1 | 154287 | 155570 | tig/ropA | 0.0 | Trigger factor | Stress survival | 80.58 | 99.77 | WP_000107753 |
BLASTN v2.16.0 (Database: VFDB, Dec. 2024 release)
VirulenceFinder
| Query ID | Begin | End | Database | Virulence factor | Protein function | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
VirulenceFinder v2.0. 4 (Database: virulencefinder_db, Feb . 2024 release)
Pathogenic genes
PHI-base
| Query ID | qstart | qend | Gene name | e-value | Function | Identity | Coverage | Gene ID |
|---|---|---|---|---|---|---|---|---|
| CICCLELB_1 | 1158982 | 1159965 | ldh(Sp_1220) | 0.0 | L-lactate dehydrogenase | 94.82 | 100.00 | AAK75326 |
| CICCLELB_1 | 720219 | 721292 | MntE | 0.0 | manganese homeostasis | 94.41 | 99.72 | ABF32167 |
| CICCLELB_1 | 1508652 | 1510955 | pfl2(Sp_0459) | 0.0 | formate acetyltransferase | 92.97 | 99.22 | AAK74619 |
| CICCLELB_1 | 532465 | 533433 | spr0084 | 0.0 | pathogenitcity related | 92.57 | 98.48 | AAK98888 |
| CICCLELB_1 | 1228118 | 1229599 | SPD_0310 | 0.0 | UPF0371 protein SPD_0310 | 92.31 | 100.00 | ABJ54480 |
| CICCLELB_1 | 752134 | 754380 | metE | 0.0 | methionine biosynthesis enzymes | 91.99 | 100.00 | AAK74738 |
| CICCLELB_1 | 70336 | 71328 | recA | 0.0 | DNA recombination and repair | 91.24 | 85.31 | AAL00560 |
| CICCLELB_1 | 27201 | 28172 | prsA2 | 0.0 | ribose-phosphate pyrophosphokinase | 90.12 | 100.00 | ABF36968 |
| CICCLELB_1 | 1394840 | 1393689 | potA | 0.0 | ABC transporter ATP-binding protein-spermidine/putrescine transport | 89.32 | 99.74 | AAL00050 |
| CICCLELB_1 | 1358945 | 1356957 | uvrB | 0.0 | excinuclease ABC, B subunit | 88.84 | 100.00 | AE014259_2 |
| CICCLELB_1 | 1142784 | 1141054 | ptsI | 0.0 | phosphoenolpyruvate-protein phosphotransferase | 87.87 | 100.00 | AAK34199 |
| CICCLELB_1 | 1828082 | 1826604 | IMPDH | 0.0 | inosine-5'-monophosphate dehydrogenase | 87.42 | 100.00 | ADE32434 |
| CICCLELB_1 | 616067 | 617368 | Eno | 0.0 | enolase | 86.21 | 99.77 | ABP90468 |
| CICCLELB_1 | 1812893 | 1811001 | gidA | 0.0 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme | 86.05 | 98.90 | ABP91129 |
| CICCLELB_1 | 757305 | 755596 | PGM | 0.0 | phosphoglucomutase | 84.06 | 99.65 | ACH87041 |
| CICCLELB_1 | 1673310 | 1674320 | pdh | 0.0 | pyruvate dehydrogenase | 82.79 | 99.70 | ABP91006 |
| CICCLELB_1 | 900702 | 899341 | mnmE | 0.0 | central tRNA-modifying GTPase | 82.24 | 99.56 | ABP90420 |
| CICCLELB_1 | 1725332 | 1723440 | PepO | 0.0 | endopeptidase | 80.19 | 100.00 | ABF32980 |
| CICCLELB_1 | 601632 | 602522 | bglB | 5.21e-178 | putative phospho--glucosidase | 88.55 | 99.66 | AAK33487 |
| CICCLELB_1 | 816201 | 815266 | SP_0676 | 7.33e-168 | transcription facot | 81.73 | 96.89 | AAK74821 |
| CICCLELB_1 | 754572 | 755429 | metF | 1.52e-164 | methionine biosynthesis enzymes | 86.36 | 99.31 | AAK74739 |
| CICCLELB_1 | 1020513 | 1019809 | covR | 4.35e-131 | responder protein | 85.53 | 100.00 | AAK71319 |
| CICCLELB_1 | 1209143 | 1208472 | rr01 | 2.98e-124 | response regulator | 83.93 | 99.56 | CAB54566 |
| CICCLELB_1 | 1020513 | 1019809 | walR | 1.83e-121 | DNA-binding response regulator | 82.13 | 100.00 | ANC99504 |
| CICCLELB_1 | 308717 | 309403 | CovR | 1.02e-117 | serves to repress GAS virulence factor-encoding genes | 80.79 | 100.00 | ACE75886 |
| CICCLELB_1 | 761259 | 761927 | CiaR | 2.00e-117 | two-component response regulator | 84.31 | 99.55 | AAK74935 |
| CICCLELB_1 | 761259 | 761930 | ciaR | 1.97e-115 | two component system response regulator | 82.14 | 99.12 | AIK75708 |
| CICCLELB_1 | 71625 | 71999 | SpxA2 | 1.14e-69 | transcriptional regulator | 91.20 | 94.70 | ERL21461 |
| CICCLELB_1 | 912066 | 912467 | SpxA1 | 3.73e-66 | transcriptional regulator | 80.60 | 100.00 | ERL19273 |
| CICCLELB_1 | 155728 | 156228 | RopE (M5005_Spy_1611) | 4.88e-75 | probable DNA-directed RNA polymerase subunit delta | 81.44 | 87.43 | AAK34603 |
| CICCLELB_1 | 1508652 | 1510949 | PFL (B9H01_RS01125) | 0.0 | formate C-acetyltransferase | 82.94 | 98.08 | MYN69560 |
| CICCLELB_1 | 1710858 | 1709839 | ilvC (SPD_0406) | 0.0 | ketol-acid reductoisomerase (NADP(+)) | 96.47 | 100.00 | ABJ55451 |
BLASTX v2.16.0 (Database: PHI base v4.16, May. 2024 release)
Plasmid
PlasmidFinder
| Query ID | Begin | End | Plasmid | Query / Template | Identity | Accession no. |
|---|---|---|---|---|---|---|
| No hit found | ||||||
PlasmidFinder v 2.1.6 (Database: plasmidfinder_db v 2.2.0 , Nov. 2024 release)
PlasmidHunter
| Query ID | Prediction | Chromosome | Plasmid |
|---|---|---|---|
| CICCLELB_1 | 0.0 | 1.0 | 0.0 |
PlasmidHunter v 1.4.5 (Database: May. 2024 release)
Prophage
Phigaro
| Query ID | Begin | End | Transposable | Taxonomy | pVOGs |
|---|---|---|---|---|---|
| No hit found | |||||
Phigaro v2.4.0 (Database: Jan. 2024 release)