Probiotic potential risk score
| ARGs | VFs | PGs | PPRS |
|---|---|---|---|
| 0 | 28 | 28 | 39.60 |
PPRS is classified as low-risk (≤4), medium-risk (4-6), and high-risk (≥6).
Antibiotic resistance genes
Comprehensive Antibiotic Resistance Database (CARD)
| Query ID | Begin | End | ARO name | ARO accession | CARD name | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
RGI v6.0.3 (Database: CARD Variants v4.0.2, Nov. 2023 release)
ResFinder
| Query ID | Begin | End | Resistance gene | Phenotype | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|
| No hit found | |||||||
ResFinder v4.6.0 (Database: resfinder_db, Aug. 2024 release)
AMRFinderPlus
| Query ID | Begin | End | Gene symbol | Sequence name | Method | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
AMRFinderPlus v4.0.3 (Database: Oct. 2024 release)
Virulence factors
Virulence Factor Database (VFDB)
| Query ID | qstart | qend | Gene name | e-value | VF name | VF category | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|---|
| HLHDPEDG_1 | 1087087 | 1087956 | rfbA | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011681286 |
| HLHDPEDG_1 | 1086494 | 1087087 | STER_RS06030 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011226149 |
| HLHDPEDG_1 | 1300410 | 1301219 | STU_RS16245 | 0.0 | Capsule | Immune modulation | 99.88 | 100.00 | WP_002948020 |
| HLHDPEDG_1 | 1086494 | 1087087 | STR_RS05880 | 0.0 | Capsule | Immune modulation | 99.83 | 100.00 | WP_011226149 |
| HLHDPEDG_1 | 1301203 | 1302159 | STU_RS16250 | 0.0 | Capsule | Immune modulation | 99.79 | 100.00 | WP_011226328 |
| HLHDPEDG_1 | 1302156 | 1303304 | STU_RS16255 | 0.0 | Capsule | Immune modulation | 99.74 | 100.00 | WP_041828290 |
| HLHDPEDG_1 | 1299205 | 1300410 | STU_RS16240 | 0.0 | Capsule | Immune modulation | 99.67 | 100.00 | WP_011226326 |
| HLHDPEDG_1 | 1086494 | 1087087 | STU_RS15260 | 0.0 | Capsule | Immune modulation | 99.66 | 100.00 | WP_011226149 |
| HLHDPEDG_1 | 1306800 | 1307651 | rfbD | 0.0 | Capsule | Immune modulation | 99.65 | 100.00 | WP_014621820 |
| HLHDPEDG_1 | 43684 | 44523 | cbpD | 0.0 | Autolysin | Exoenzyme | 99.52 | 100.00 | WP_011226733 |
| HLHDPEDG_1 | 857267 | 858925 | fbp54 | 0.0 | FBPs | Adherence | 99.52 | 100.00 | WP_011227179 |
| HLHDPEDG_1 | 1296349 | 1298133 | STU_RS16230 | 0.0 | Capsule | Immune modulation | 99.50 | 100.00 | WP_011226325 |
| HLHDPEDG_1 | 1298130 | 1299185 | STU_RS16235 | 0.0 | Capsule | Immune modulation | 99.43 | 100.00 | WP_002948022 |
| HLHDPEDG_1 | 1303413 | 1304423 | STU_RS16260 | 0.0 | Capsule | Immune modulation | 99.41 | 100.00 | WP_011226330 |
| HLHDPEDG_1 | 964903 | 965634 | STER_RS05315 | 0.0 | Capsule | Immune modulation | 99.04 | 100.00 | WP_011681176 |
| HLHDPEDG_1 | 965635 | 967095 | STER_RS05320 | 0.0 | Capsule | Immune modulation | 98.97 | 100.00 | WP_011681177 |
| HLHDPEDG_1 | 1031598 | 1032386 | cshA | 0.0 | Cell surface hydrophobicity proteins | Adherence | 98.36 | 99.75 | - |
| HLHDPEDG_1 | 964903 | 965634 | STR_RS05260 | 0.0 | Capsule | Immune modulation | 98.09 | 100.00 | WP_011227248 |
| HLHDPEDG_1 | 964903 | 965634 | STU_RS14645 | 0.0 | Capsule | Immune modulation | 97.95 | 100.00 | WP_011226048 |
| HLHDPEDG_1 | 1123279 | 1124040 | srtA | 0.0 | Sortase A | Exoenzyme | 97.64 | 100.00 | - |
| HLHDPEDG_1 | 1304426 | 1305697 | STU_RS16265 | 0.0 | Capsule | Immune modulation | 97.48 | 99.76 | WP_011226331 |
| HLHDPEDG_1 | 965635 | 967095 | STU_RS14650 | 0.0 | Capsule | Immune modulation | 97.26 | 100.21 | WP_011226049 |
| HLHDPEDG_1 | 963452 | 964192 | STU_RS14635 | 0.0 | Capsule | Immune modulation | 97.17 | 100.00 | WP_011226046 |
| HLHDPEDG_1 | 963452 | 964192 | STER_RS05305 | 0.0 | Capsule | Immune modulation | 96.76 | 100.00 | WP_011681174 |
| HLHDPEDG_1 | 965635 | 967095 | STR_RS05265 | 0.0 | Capsule | Immune modulation | 96.72 | 100.21 | WP_041827043 |
| HLHDPEDG_1 | 960790 | 961786 | STU_RS14625* | 0.0 | Capsule | Immune modulation | 96.69 | 100.00 | - |
| HLHDPEDG_1 | 963457 | 964192 | STR_RS05250 | 0.0 | Capsule | Immune modulation | 96.20 | 98.13 | WP_011227246 |
| HLHDPEDG_1 | 962028 | 963395 | STU_RS14630 | 0.0 | Capsule | Immune modulation | 95.54 | 100.00 | WP_011226045 |
| HLHDPEDG_1 | 964202 | 964894 | STR_RS05255 | 0.0 | Capsule | Immune modulation | 95.40 | 99.86 | WP_011227247 |
| HLHDPEDG_1 | 964202 | 964894 | STU_RS14640 | 0.0 | Capsule | Immune modulation | 95.40 | 99.86 | WP_011226047 |
| HLHDPEDG_1 | 962030 | 963395 | STER_RS05300 | 0.0 | Capsule | Immune modulation | 94.88 | 99.85 | WP_011681173 |
| HLHDPEDG_1 | 964202 | 964894 | STER_RS05310 | 0.0 | Capsule | Immune modulation | 89.75 | 100.00 | WP_011681175 |
| HLHDPEDG_1 | 596066 | 597369 | eno | 0.0 | Streptococcal enolase | Exoenzyme | 88.10 | 99.46 | WP_000022832 |
| HLHDPEDG_1 | 1594822 | 1595832 | plr/gapA | 0.0 | Streptococcal plasmin receptor/GAPDH | Adherence | 86.54 | 99.41 | WP_002986042 |
| HLHDPEDG_1 | 148356 | 149639 | tig/ropA | 0.0 | Trigger factor | Stress survival | 80.65 | 99.77 | WP_000107753 |
| HLHDPEDG_1 | 1085019 | 1086065 | rfbB | 0.0 | Capsule | Immune modulation | 80.61 | 100.00 | WP_009659423 |
| HLHDPEDG_1 | 960332 | 960781 | STU_RS14620 | 2.83e-177 | Capsule | Immune modulation | 92.00 | 100.00 | WP_011226042 |
| HLHDPEDG_1 | 950746 | 951329 | SPD_RS01775 | 2.28e-148 | Capsule | Immune modulation | 83.25 | 96.20 | WP_001819836 |
| HLHDPEDG_1 | 959971 | 960332 | STU_RS14615 | 1.17e-81 | Capsule | Immune modulation | 82.51 | 73.87 | WP_011226041 |
BLASTN v2.16.0 (Database: VFDB, Dec. 2024 release)
VirulenceFinder
| Query ID | Begin | End | Database | Virulence factor | Protein function | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
VirulenceFinder v2.0. 4 (Database: virulencefinder_db, Feb . 2024 release)
Pathogenic genes
PHI-base
| Query ID | qstart | qend | Gene name | e-value | Function | Identity | Coverage | Gene ID |
|---|---|---|---|---|---|---|---|---|
| HLHDPEDG_1 | 1126727 | 1127710 | ldh(Sp_1220) | 0.0 | L-lactate dehydrogenase | 94.82 | 100.00 | AAK75326 |
| HLHDPEDG_1 | 702850 | 703923 | MntE | 0.0 | manganese homeostasis | 94.13 | 99.72 | ABF32167 |
| HLHDPEDG_1 | 512385 | 513353 | spr0084 | 0.0 | pathogenitcity related | 93.19 | 98.48 | AAK98888 |
| HLHDPEDG_1 | 1471898 | 1474201 | pfl2(Sp_0459) | 0.0 | formate acetyltransferase | 92.97 | 99.22 | AAK74619 |
| HLHDPEDG_1 | 1196630 | 1198111 | SPD_0310 | 0.0 | UPF0371 protein SPD_0310 | 92.31 | 100.00 | ABJ54480 |
| HLHDPEDG_1 | 732660 | 734906 | metE | 0.0 | methionine biosynthesis enzymes | 91.99 | 100.00 | AAK74738 |
| HLHDPEDG_1 | 64187 | 65188 | recA | 0.0 | DNA recombination and repair | 91.02 | 86.08 | AAL00560 |
| HLHDPEDG_1 | 27202 | 28173 | prsA2 | 0.0 | ribose-phosphate pyrophosphokinase | 90.12 | 100.00 | ABF36968 |
| HLHDPEDG_1 | 1358133 | 1356982 | potA | 0.0 | ABC transporter ATP-binding protein-spermidine/putrescine transport | 89.32 | 99.74 | AAL00050 |
| HLHDPEDG_1 | 1322640 | 1320652 | uvrB | 0.0 | excinuclease ABC, B subunit | 88.99 | 100.00 | AE014259_2 |
| HLHDPEDG_1 | 1110531 | 1108801 | ptsI | 0.0 | phosphoenolpyruvate-protein phosphotransferase | 88.04 | 100.00 | AAK34199 |
| HLHDPEDG_1 | 1789825 | 1788347 | IMPDH | 0.0 | inosine-5'-monophosphate dehydrogenase | 87.42 | 100.00 | ADE32434 |
| HLHDPEDG_1 | 596066 | 597367 | Eno | 0.0 | enolase | 86.21 | 99.77 | ABP90468 |
| HLHDPEDG_1 | 1774636 | 1772744 | gidA | 0.0 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme | 86.05 | 98.90 | ABP91129 |
| HLHDPEDG_1 | 737831 | 736122 | PGM | 0.0 | phosphoglucomutase | 84.06 | 99.65 | ACH87041 |
| HLHDPEDG_1 | 1636814 | 1637824 | pdh | 0.0 | pyruvate dehydrogenase | 83.09 | 99.70 | ABP91006 |
| HLHDPEDG_1 | 882340 | 880979 | mnmE | 0.0 | central tRNA-modifying GTPase | 82.24 | 99.56 | ABP90420 |
| HLHDPEDG_1 | 1687082 | 1685190 | PepO | 0.0 | endopeptidase | 80.03 | 100.00 | ABF32980 |
| HLHDPEDG_1 | 581631 | 582521 | bglB | 1.29e-177 | putative phospho--glucosidase | 88.55 | 99.66 | AAK33487 |
| HLHDPEDG_1 | 795793 | 794858 | SP_0676 | 7.18e-168 | transcription facot | 81.73 | 96.89 | AAK74821 |
| HLHDPEDG_1 | 735098 | 735955 | metF | 1.49e-164 | methionine biosynthesis enzymes | 86.36 | 99.31 | AAK74739 |
| HLHDPEDG_1 | 1003916 | 1003212 | covR | 4.26e-131 | responder protein | 85.53 | 100.00 | AAK71319 |
| HLHDPEDG_1 | 1177655 | 1176984 | rr01 | 2.92e-124 | response regulator | 83.93 | 99.56 | CAB54566 |
| HLHDPEDG_1 | 1003916 | 1003212 | walR | 1.79e-121 | DNA-binding response regulator | 82.13 | 100.00 | ANC99504 |
| HLHDPEDG_1 | 302817 | 303503 | CovR | 3.00e-118 | serves to repress GAS virulence factor-encoding genes | 81.22 | 100.00 | ACE75886 |
| HLHDPEDG_1 | 741785 | 742453 | CiaR | 1.96e-117 | two-component response regulator | 84.31 | 99.55 | AAK74935 |
| HLHDPEDG_1 | 741785 | 742456 | ciaR | 1.93e-115 | two component system response regulator | 82.14 | 99.12 | AIK75708 |
| HLHDPEDG_1 | 65461 | 65856 | SpxA2 | 1.13e-73 | transcriptional regulator | 90.15 | 100.00 | ERL21461 |
| HLHDPEDG_1 | 149797 | 150297 | RopE (M5005_Spy_1611) | 4.78e-75 | probable DNA-directed RNA polymerase subunit delta | 81.44 | 87.43 | AAK34603 |
| HLHDPEDG_1 | 1471898 | 1474195 | PFL (B9H01_RS01125) | 0.0 | formate C-acetyltransferase | 82.94 | 98.08 | MYN69560 |
| HLHDPEDG_1 | 1672675 | 1671656 | ilvC (SPD_0406) | 0.0 | ketol-acid reductoisomerase (NADP(+)) | 95.88 | 100.00 | ABJ55451 |
BLASTX v2.16.0 (Database: PHI base v4.16, May. 2024 release)
Plasmid
PlasmidFinder
| Query ID | Begin | End | Plasmid | Query / Template | Identity | Accession no. |
|---|---|---|---|---|---|---|
| No hit found | ||||||
PlasmidFinder v 2.1.6 (Database: plasmidfinder_db v 2.2.0 , Nov. 2024 release)
PlasmidHunter
| Query ID | Prediction | Chromosome | Plasmid |
|---|---|---|---|
| HLHDPEDG_1 | 0.0 | 1.0 | 0.0 |
PlasmidHunter v 1.4.5 (Database: May. 2024 release)
Prophage
Phigaro
| Query ID | Begin | End | Transposable | Taxonomy | pVOGs |
|---|---|---|---|---|---|
| No hit found | |||||
Phigaro v2.4.0 (Database: Jan. 2024 release)