GCA_001247635.1 - 12 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaMDFAHGHL_1 (original name was: gnl|Prokka|MDFAHGHL_1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	lanthipeptide-class-ii	104,242	127,283	loseolamycin A1/loseolamycin A2	Polyketide	8%

gnlProkkaMDFAHGHL_2 (original name was: gnl|Prokka|MDFAHGHL_2)

Region	Type	From	To	Most similar known cluster		Similarity
Region 2.1	NRPS,transAT-PKS,betalactone	81,859	219,690	fengycin	NRP	93%

gnlProkkaMDFAHGHL_3 (original name was: gnl|Prokka|MDFAHGHL_3)

Region	Type	From	To	Most similar known cluster		Similarity
Region 3.1	terpene	8,210	30,093

gnlProkkaMDFAHGHL_5 (original name was: gnl|Prokka|MDFAHGHL_5)

Region	Type	From	To	Most similar known cluster		Similarity
Region 5.1	T3PKS	895	42,139
Region 5.2	transAT-PKS	159,479	263,800	difficidin	Polyketide	100%

gnlProkkaMDFAHGHL_7 (original name was: gnl|Prokka|MDFAHGHL_7)

Region	Type	From	To	Most similar known cluster		Similarity
Region 7.1	NRP-metallophore,NRPS,RiPP-like	65,773	117,560	bacillibactin	NRP	100%

gnlProkkaMDFAHGHL_8 (original name was: gnl|Prokka|MDFAHGHL_8)

Region	Type	From	To	Most similar known cluster		Similarity
Region 8.1	other	502,321	543,739	bacilysin	Other	100%

gnlProkkaMDFAHGHL_9 (original name was: gnl|Prokka|MDFAHGHL_9)

Region	Type	From	To	Most similar known cluster		Similarity
Region 9.1	NRPS	11,832	77,240	surfactin	NRP:Lipopeptide	91%

gnlProkkaMDFAHGHL_14 (original name was: gnl|Prokka|MDFAHGHL_14)

Region	Type	From	To	Most similar known cluster		Similarity
Region 14.1	PKS-like	175,458	216,702	butirosin A/butirosin B	Saccharide	7%
Region 14.2	terpene	299,485	320,225

gnlProkkaMDFAHGHL_16 (original name was: gnl|Prokka|MDFAHGHL_16)

Region	Type	From	To	Most similar known cluster		Similarity
Region 16.1	transAT-PKS	133,835	222,063	macrolactin H	Polyketide	100%
Region 16.2	transAT-PKS,T3PKS,NRPS,NRPS-like	443,342	536,922	bacillaene	Polyketide+NRP	100%

Compact view

gnlProkkaMDFAHGHL_1 - Region 1 - lanthipeptide-class-ii

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Location: 104,242 - 127,283 nt. (total: 23,042 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene overview

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Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

Lanthipeptide predictions

Lanthipeptide(s) for ctg1_109

ctg1_108

Leader:

MSEKQIERTIRAWKDPEFRKTLSDVADHPSGSIEARQLSMLGS

Core:

EENVNPMTTPVSPAPTVVIRVSLKVCPTFKIKCKV

Core with dehydrations:

EENVNPMDhbDhbPVDhaPAPDhbVVIRVDhaLKVCysPDhbFKIKCysKV

MIBiG 3.1 matches for ctg1_108

14.3% BGC0000553 (SSGG_RS09925): Lanthipeptide: SRO15-2212

20

RVSLKVC

26

+VSL VC

4

QVSLLVC

10

antiSMASH-DB 4.0 matches for ctg1_108

100.0% NZ_CP039297.1and 2 others:

NZ_CP040378.1 Lanthipeptides: D1120_RS00435_lanthipeptideNZ_CP059318.1 Lanthipeptides: HZT45_RS00565_lanthipeptide

Lanthipeptides: E4T61_RS00570_lanthipeptide

1

EENVNPMTTPVSPAPTVVIRVSLKVCPTFKIKCKV

35

EENVNPMTTPVSPAPTVVIRVSLKVCPTFKIKCKV

1

EENVNPMTTPVSPAPTVVIRVSLKVCPTFKIKCKV

35

97.1% NZ_CP040672.1and 1 other:

NZ_CP087137.1 Lanthipeptides: LOK79_RS00585_lanthipeptide

Lanthipeptides: FGE23_RS05605_lanthipeptide

1

EENVNPMTTPVSPAPTVVIRVSLKVCPTFKIKCKV

35

E+NVNPMTTPVSPAPTVVIRVSLKVCPTFKIKCKV

1

EDNVNPMTTPVSPAPTVVIRVSLKVCPTFKIKCKV

35

42.9% NC_018499.1and 5 others:

NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27845_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide

Lanthipeptides: BCK_RS27845_lanthipeptide

3

NVNPMTTPVSPAPTVVIRVSLKVCPTFKIKCK

34

+VNP TTP +P ++ VSL +CPT K K

2

DVNPETTPATP---TIVAVSLGICPTTKCTSK

30

with 43 more sequence matches

42.9% NZ_CP023481.1and 2 others:

NZ_JALARN010000006.1 Lanthipeptides: MOE03_RS17410_lanthipeptideNZ_JAQCPU010000013.1 Lanthipeptides: PG077_RS20425_lanthipeptide

Lanthipeptides: COP00_RS24795_lanthipeptide

5

NPMTTPVSPAPTVVIRV---SLKVCPTFKIKC

33

N TP S V +RV S+K CP+FK KC

1

NDEITPQSTVVCVSLRVCKWSIKYCPSFKRKC

32

42.9% NZ_PIJH01000018.1: Lanthipeptides: CV632_RS18055_lanthipeptide

9

TPVSPAPTVV---IRV---SLKVCPTFKIKC

33

T VSP T+V +R+ SL+ CP+FK+KC

2

TEVSPQSTIVCVSLRICNWSLRFCPSFKVKC

32

40.0% NC_009328.1: Lanthipeptides: GTNG_RS18990_lanthipeptide

9

TPVSPAPTVV---IRV---SLKVCPTFKIKC

33

T VSP T+V +R+ SL+ CP+FK++C

2

TEVSPQSTIVCVSLRICNWSLRFCPSFKVRC

32

40.0% NZ_CP013862.1and 1 other:

NZ_CP013862.1 Lanthipeptides: AOX59_RS09365_lanthipeptide

Lanthipeptides: AOX59_RS09365_lanthipeptide

3

NVNPMTTPVSPAPTVVIRVSLKVCPTFK

30

+V+P TTP S A I VS CPT K

2

DVDPQTTPSSVA--CGIAVSALFCPTTK

27

40.0% NZ_CP015591.1and 15 others:

NZ_CP078085.1 Lanthipeptides: KU891_RS29355_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29350_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29345_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29340_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29335_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptide

Lanthipeptides: A7A70_RS27550_lanthipeptide

3

NVNPMTTPVSPAPTVV---IRVSLKVCPTFK

30

+VNP TTP + PT+V I ++ +CPT K

2

DVNPETTPAT--PTIVEATIAATVSICPTTK

30

40.0% NZ_CP036019.1and 1 other:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27205_lanthipeptide

Lanthipeptides: EXW52_RS27205_lanthipeptide

3

NVNPMTTPVSPAPTVVIRVSLKVCPTFKIKCK

34

+V+P TTP +P T+V+ +S+ +CPT K K

2

DVSPETTPATP--TIVVAISVGLCPTTKCTSK

31

40.0% NZ_JALAJI010000006.1and 3 others:

NZ_JALAOO010000008.1 Lanthipeptides: MOC69_RS16910_lanthipeptideNZ_JALAXE010000008.1 Lanthipeptides: MOF11_RS14910_lanthipeptideNZ_JALAXI010000013.1 Lanthipeptides: MOE73_RS14185_lanthipeptide

Lanthipeptides: MOB90_RS08905_lanthipeptide

5

NPMTTPVSPAPTVVIRV---SLKVCPTFKIKC

33

N TP S V +R+ S+K CP+FK KC

1

NDEITPQSTVVCVSLRLCKWSIKYCPSFKKKC

32

40.0% NZ_JALANL010000003.1and 3 others:

NZ_MUEI01000003.1 Lanthipeptides: BV582_RS23575_lanthipeptideNZ_NIJN01000002.1 Lanthipeptides: CHCC5027_RS22460_lanthipeptideNZ_NIMF01000037.1 Lanthipeptides: CHCC14814_RS22115_lanthipeptide

Lanthipeptides: MOC63_RS03255_lanthipeptide

5

NPMTTPVSPAPTVVIRV---SLKVCPTFKIKC

33

N TP S V +R+ S+K CP+FK KC

1

NDEITPQSTVVCVSLRICKWSIKYCPSFKRKC

32

40.0% NZ_NUML01000015.1: Lanthipeptides: COD66_RS20140_lanthipeptide

3

NVNPMTTPVSPAPTVVIRVSLKVCPTFKIKCK

34

+V+P TTP +P T+V+ +S+ +CPT K K

2

DVSPETTPATP--TIVVGISVGLCPTTKCTSK

31

38.5% NZ_CP009280.1and 1 other:

NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide

Lanthipeptides: P40081_RS37160_lanthipeptide

3

NVNPMTTPV--SPAPTVV--IRVSLKVCPTFKIKCK

34

+VNP TTP+ S P V+ + +S +CPT K K

3

DVNPETTPLTTSSWPCVIGAVDISANLCPTTKCTSK

38

37.1% NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

3

NVNPMTTPVSPA-PTVVIRVSLKVCPTFK

30

+VNP TTP +P I V+ +CPT K

2

DVNPETTPATPTIIGATIAVTASLCPTTK

30

37.1% NZ_CP036019.1and 7 others:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27180_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27175_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27170_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27190_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27180_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27175_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27170_lanthipeptide

Lanthipeptides: EXW52_RS27190_lanthipeptide

3

NVNPMTTPVSPAPTVVIRVSLKVCPTFKIKCK

34

+V+P TTP +P T+V+ +S+ +CPT + K

2

DVSPETTPATP--TIVVAISVGLCPTNRCTSK

31

37.1% NZ_FOHE01000009.1: Lanthipeptides: BMX40_RS20255_lanthipeptide

2

ENVNPMTTPVSPAPTVVIRVSLKVCPTFKIKC

33

E V P +T V + + + S+K CP+FK KC

2

EEVTPQSTVVCVSLRLC-KWSIKYCPSFKRKC

32

37.1% NZ_MLKL01000042.1: Lanthipeptides: BKK45_RS27405_lanthipeptide

3

NVNPMTTPVSPAPTVVIRVSLKVCPT

28

+VNP TTP +P ++ VS+K+CPT

2

DVNPETTPATP---TIVAVSVKLCPT

24

34.3% NZ_CACZYW010000004.1and 3 others:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide

Lanthipeptides: HUF10_RS02820_lanthipeptide

8

TTPVSPAPTVVIRVSL----KVCPT

28

TTP +PA V++ VS K CPT

1

TTPATPATPVIVAVSAYVSDKTCPT

25

34.3% NZ_CP036019.1and 1 other:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27195_lanthipeptide

Lanthipeptides: EXW52_RS27195_lanthipeptide

3

NVNPMTTPVSPAPTVVIRVSLKVCPT

28

+V+P TTP +P T+V+ +S+ +CPT

2

DVSPETTPATP--TIVVAISVGLCPT

25

34.3% NZ_JAMDLZ010000027.1: Lanthipeptides: M5W82_RS15520_lanthipeptide

2

ENVNPMTTPVSPAPTVVIRVSLKVCPTFK

30

+ P TP+ TV I +SL CPT K

1

SEIQPKWTPL----TVTIPISLAGCPTTK

25

34.3% NZ_JAQQWR010000009.1: Lanthipeptides: PQ473_RS20190_lanthipeptide

2

ENVNPMTTPVSPAPTV--VIRVSLKVC

26

+VNP TTP+ A +V I S+K C

1

SDVNPETTPLCVAYSVGATIVFSVKHC

27

34.2% NC_006322.1and 7 others:

NC_006322.1 Lanthipeptides: BLI_RS20290_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptide

Lanthipeptides: BLI_RS20290_lanthipeptide

2

ENVNPMTTPVSPAP----TVVIRVSLKVCPTFK

30

+VNP TTP + + T + VS +CPT K

1

NDVNPETTPATTSSWTCITAGVTVSASLCPTTK

33

31.4% NZ_JAHHYI010000012.1: Lanthipeptides: KM925_RS25405_lanthipeptide

3

NVNPMTTP--VSPAPTVVIRVSLKVC

26

+V P TTP V TV I +S +C

2

DVQPETTPACVGAGITVGIAISKLLC

27

30.8% NZ_CP009288.1and 3 others:

NZ_CP009288.1 Lanthipeptides: PDUR_RS29295_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptide

Lanthipeptides: PDUR_RS29295_lanthipeptide

3

NVNPMTTPVSPAP----TVVIRVSLKVCPTFK

30

+VNP TT ++ + T + VS +CPT K

3

DVNPETTILTTSSWTCITAGVTVSASLCPTTK

34

28.6% NZ_WIXN01000006.1and 1 other:

NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide

Lanthipeptides: GHD25_RS06900_lanthipeptide

15

PTVVIRVSLKVCPT

28

PT +I VSL VCPT

9

PTTIIPVSLAVCPT

22

25.7% NZ_BOSN01000007.1and 5 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptideNZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptideNZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide

Lanthipeptides: KJS43_RS18000_lanthipeptide

15

PTVVIRVSLKVCPTFK

30

P +I VSL +CPT K

8

PATIIPVSLAICPTTK

23

25.7% NZ_CP028922.1: Lanthipeptides: allorf_4058819_4059013_lanthipeptide

7

MTTPVSPAPTVVIRVSLKVCPTFKIKCKV

35

+ TP S + K CPT+ KC +

7

ICTPGSCDGDRCWLTTFKGCPTYGPKCDI

35

25.7% NZ_CP067069.1and 13 others:

NZ_CP085413.1 Lanthipeptides: LIS80_RS25350_lanthipeptideNZ_JH792105.1 Lanthipeptides: II5_RS26960_lanthipeptideNZ_JH792240.1 Lanthipeptides: IIK_RS26240_lanthipeptideNZ_MOOT01000061.1 Lanthipeptides: BK765_RS23985_lanthipeptideNZ_NTUF01000024.1 Lanthipeptides: CN379_RS26680_lanthipeptideNZ_NVCZ01000001.1 Lanthipeptides: COK75_RS01180_lanthipeptideNZ_NVDK01000008.1 Lanthipeptides: COK95_RS05665_lanthipeptideNZ_NVEA01000001.1 Lanthipeptides: COL15_RS00010_lanthipeptideNZ_PIYQ01000022.1 Lanthipeptides: CW365_RS08190_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20675_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19560_lanthipeptideNZ_WBPE01000025.1 Lanthipeptides: F8161_RS14435_lanthipeptideNZ_WBPK01000016.1 Lanthipeptides: F8167_RS15685_lanthipeptide

Lanthipeptides: JCR32_RS24620_lanthipeptide

2

ENVNPMTTPVSPAPTVVIRVSLKVC

26

+V P TTP+ + I S+K+C

1

SDVQPETTPLCVGVIIGITASIKIC

25

25.7% NZ_JACSMH010000008.1and 2 others:

NZ_JACSMX010000006.1 Lanthipeptides: KNQ03_RS15615_lanthipeptideNZ_JACSMZ010000005.1 Lanthipeptides: KNQ06_RS16025_lanthipeptide

Lanthipeptides: KNP89_RS14470_lanthipeptide

3

NVNPMTTPVSPAPTVVIRVSLKVC

26

+V P TTP V + +SL C

2

DVQPETTPFCVGVIVGVTISLSKC

25

25.7% NZ_JACYTN010000030.1: Lanthipeptides: allorf_08178_08354_lanthipeptide

7

MTTPVSPAPTVVIRVSLKVCPTFKIKCKV

35

+ TP S + + K CPT+ KC +

7

ICTPGSCSGDSCWLTTFKGCPTYGPKCDI

35

25.7% NZ_LDKE01000067.1: Lanthipeptides: ABB04_RS19960_lanthipeptide

2

ENVNPMTTPVSPAPTVVIRVSLKVC

26

+V P TTP+ + I S+K+C

1

SDVKPETTPLCVGVIIGITASIKIC

25

25.7% NZ_NIST01000001.1: Lanthipeptides: CD001_RS09870_lanthipeptide

5

NPMTTPVSPAPTVVIRVSLKVCPT

28

+ TP T+ RVSL C T

2

GGICTPSCLTGTLNCRVSLTFCRT

25

23.8% NZ_CP010976.1: Lanthipeptides: UB51_RS20985_lanthipeptide

3

NVNPMTTPVSPAPTVVI

19

+VNP TTP + PT+VI

2

DVNPETTPAT--PTIVI

16

22.9% NZ_CP016020.1and 34 others:

NZ_CP067069.1 Lanthipeptides: JCR32_RS24625_lanthipeptideNZ_CP085413.1 Lanthipeptides: LIS80_RS25380_lanthipeptideNZ_CP085413.1 Lanthipeptides: LIS80_RS25375_lanthipeptideNZ_CP085413.1 Lanthipeptides: LIS80_RS25370_lanthipeptideNZ_CP085413.1 Lanthipeptides: LIS80_RS25365_lanthipeptideNZ_CP085413.1 Lanthipeptides: LIS80_RS25360_lanthipeptideNZ_CP085413.1 Lanthipeptides: LIS80_RS25355_lanthipeptideNZ_JH792105.1 Lanthipeptides: II5_RS26955_lanthipeptideNZ_LDKE01000067.1 Lanthipeptides: ABB04_RS19955_lanthipeptideNZ_LDKE01000067.1 Lanthipeptides: ABB04_RS19940_lanthipeptideNZ_LDKE01000067.1 Lanthipeptides: ABB04_RS19935_lanthipeptideNZ_MOOT01000061.1 Lanthipeptides: BK765_RS23995_lanthipeptideNZ_MOOT01000061.1 Lanthipeptides: BK765_RS23990_lanthipeptideNZ_NVEA01000001.1 Lanthipeptides: COL15_RS00005_lanthipeptideNZ_PIYQ01000022.1 Lanthipeptides: CW365_RS08185_lanthipeptideNZ_PIYQ01000022.1 Lanthipeptides: CW365_RS08180_lanthipeptideNZ_PIYQ01000022.1 Lanthipeptides: CW365_RS08175_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20670_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20665_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20660_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20655_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20650_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20645_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19555_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19550_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19545_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19540_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19535_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19530_lanthipeptideNZ_WBPE01000025.1 Lanthipeptides: F8161_RS14445_lanthipeptideNZ_WBPE01000025.1 Lanthipeptides: F8161_RS14440_lanthipeptideNZ_WBPK01000016.1 Lanthipeptides: F8167_RS15680_lanthipeptideNZ_WBPK01000016.1 Lanthipeptides: F8167_RS15675_lanthipeptideNZ_WBPK01000016.1 Lanthipeptides: F8167_RS15670_lanthipeptide

Lanthipeptides: A9C19_RS17970_lanthipeptide

2

ENVNPMTTPVSPAPTVVIRVSLKVC

26

+V P TTP+ + + S+K+C

1

SDVQPETTPLCVGVIIGLTTSIKIC

25

22.9% NZ_CP036019.1and 1 other:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27165_lanthipeptide

Lanthipeptides: EXW52_RS27165_lanthipeptide

3

NVNPMTTPVSPAPTVVIRVSLKVCPTF

29

+VNP T P + P ++ ++ ++CP+

2

DVNPETIPATATP-ILANLTKELCPSI

27

22.9% NZ_CP063142.1and 1 other:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21460_lanthipeptide

Lanthipeptides: HPB58_RS21460_lanthipeptide

16

TVVIRVSLKVCPT

28

TV I +SL CPT

8

TVTIPISLAACPT

20

22.9% NZ_CP063142.1and 5 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide

Lanthipeptides: HPB58_RS21455_lanthipeptide

16

TVVIRVSLKVCPTFK

30

TV I +SL CPT +

8

TVTIPISLAACPTTQ

22

22.9% NZ_CP101913.1and 1 other:

NZ_CP101913.1 Lanthipeptides: NP440_RS09140_lanthipeptide

Lanthipeptides: NP440_RS09140_lanthipeptide

15

PTVVIRVSLKVCPTFK

30

PTV I +S +CPT +

8

PTVTIPISAAICPTTQ

23

22.9% NZ_KE384107.1: Lanthipeptides: G586_RS26715_lanthipeptide

11

VSPAPTVVIRVSLKVCPTFK

30

V+P ++I S CPT K

6

VAPVVPIIIAASTAFCPTIK

25

22.9% NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide

Lanthipeptides: WH45_RS23705_lanthipeptide

15

PTVVIRVSLKVCPTFK

30

P +I VSL +CPT +

9

PATIIPVSLAICPTTR

24

22.9% NZ_LDFC01000091.1: Lanthipeptides: ABE61_RS23570_lanthipeptide

13

PAPTVVIRVSLKVC

26

P PTVV VS+ +C

6

PPPTVVSSVSIWIC

19

22.9% NZ_LT985747.1: Lanthipeptides: C8268_RS22865_lanthipeptide

7

MTTPVSPAPTVVIRVSLKVCPTFKIKCKV

35

+ TP S + + + + CPT+ KC +

7

ICTPGSCSGNNCVLTTWRGCPTYGPKCDI

35

22.9% NZ_NUML01000015.1: Lanthipeptides: COD66_RS20280_lanthipeptide

3

NVNPMTTPVSPAPTVVIRVSLKVCPTF

29

++NP T P +P P +++ ++ ++CP+

2

DMNPETIPATPTP-ILVNLTKELCPSI

27

20.0% NZ_BQME02000001.1and 5 others:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide

Lanthipeptides: MFF31_RS04080_lanthipeptide

16

TVVIRVSLKVCPTFK

30

T++I +SL CPT +

6

TIIIPISLAACPTTR

20

18.9% NZ_CM001792.1and 1 other:

NZ_CM001792.1 Lanthipeptides: C794_RS17975_lanthipeptide

Lanthipeptides: C794_RS17975_lanthipeptide

9

TPVSPAPTVVIRVSLKVCPT

28

+P++P+ + +SL CPT

8

SPLTPSSGSCVAISLAFCPT

27

17.1% NZ_MJEJ02000054.1and 3 others:

NZ_MJEJ02000054.1 Lanthipeptides: BH683_RS28810_lanthipeptideNZ_QJSP01000005.1 Lanthipeptides: DFR67_RS30760_lanthipeptideNZ_QJSP01000005.1 Lanthipeptides: DFR67_RS30760_lanthipeptide

Lanthipeptides: BH683_RS28810_lanthipeptide

21

VSLKVCPTFK

30

+S+ +CPTFK

12

LSVALCPTFK

21

allorf_105014_105088

Leader:

MTGARTSGGA

Core:

CGLIRSNAKNLTRS

Core with dehydrations:

CysGLIRDhaNAKNLDhbRDha

antiSMASH-DB 4.0 matches for allorf_105014_105088

100.0% NC_021362.1and 11 others:

NZ_AP025342.1 Lanthipeptides: allorf_1476567_1476641_lanthipeptideNZ_AP026714.1 Lanthipeptides: allorf_1207193_1207267_lanthipeptideNZ_CP010524.1 Lanthipeptides: allorf_0181624_0181698_lanthipeptideNZ_CP020352.1 Lanthipeptides: allorf_0187351_0187425_lanthipeptideNZ_CP023168.1 Lanthipeptides: allorf_0187408_0187482_lanthipeptideNZ_CP039297.1 Lanthipeptides: allorf_0098046_0098120_lanthipeptideNZ_CP040672.1 Lanthipeptides: allorf_1092980_1093054_lanthipeptideNZ_CP059318.1 Lanthipeptides: allorf_0097981_0098055_lanthipeptideNZ_CP087137.1 Lanthipeptides: allorf_0097877_0097951_lanthipeptideNZ_CP118744.1 Lanthipeptides: allorf_0187316_0187390_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: allorf_1660067_1660141_lanthipeptide

Lanthipeptides: allorf_0181474_0181548_lanthipeptide

1

CGLIRSNAKNLTRS

14

CGLIRSNAKNLTRS

1

CGLIRSNAKNLTRS

14

78.6% NZ_CP051884.1: Lanthipeptides: allorf_3277830_3277904_lanthipeptide

1

CGLIRSNAKNLTRS

14

CGLIR NAKNLT++

1

CGLIRCNAKNLTKA

14

allorf_105836_105952

Leader:

MDALALGADEGRDEHRYA

Core:

SGSCKQALIRRFPNGETHHS

Core with dehydrations:

DhaGDhaCysKQALIRRFPNGEDhbHHDha

antiSMASH-DB 4.0 matches for allorf_105836_105952

100.0% NZ_CP039297.1and 3 others:

NZ_CP040672.1 Lanthipeptides: allorf_1093859_1093975_lanthipeptideNZ_CP059318.1 Lanthipeptides: allorf_0098860_0098976_lanthipeptideNZ_CP087137.1 Lanthipeptides: allorf_0098698_0098814_lanthipeptide

Lanthipeptides: allorf_0098925_0099041_lanthipeptide

1

SGSCKQALIRRFPNGETHHS

20

SGSCKQALIRRFPNGETHHS

1

SGSCKQALIRRFPNGETHHS

20

30.0% NZ_CP119804.1: Lanthipeptides: allorf_1905850_1905972_lanthipeptide

9

IRRFPNGETHHS

20

I RF ++HHS

3

INRFARCDSHHS

14

20.8% NZ_KZ559472.1: Lanthipeptides: CXR44_RS39555_lanthipeptide

3

SCKQALIRRFP

13

+CK+ + RFP

8

TCKRTVCSRFP

18

allorf_106877_107011

Leader:

MIRLAPVHFRRRVTRPVSYYA

Core:

LFKWWLLLSQHPGCLSNSTSFST

Core with dehydrations:

LFKWWLLLDhaQHPGCysLDhaNDhaDhbDhaFDhaDhb

antiSMASH-DB 4.0 matches for allorf_106877_107011

100.0% NZ_CP039297.1and 3 others:

NZ_CP040672.1 Lanthipeptides: allorf_1094900_1095034_lanthipeptideNZ_CP059318.1 Lanthipeptides: allorf_0099901_0100035_lanthipeptideNZ_CP087137.1 Lanthipeptides: allorf_0099739_0099873_lanthipeptide

Lanthipeptides: allorf_0099966_0100100_lanthipeptide

1

LFKWWLLLSQHPGCLSNSTSFST

23

LFKWWLLLSQHPGCLSNSTSFST

1

LFKWWLLLSQHPGCLSNSTSFST

23

95.7% NZ_CM000721.1: Lanthipeptides: allorf_5216161_5216295_lanthipeptide

1

LFKWWLLLSQHPGCLSNSTSFST

23

LFKWWLLLSQHP CLSNSTSFST

1

LFKWWLLLSQHPSCLSNSTSFST

23

19.4% NC_015711.1: Lanthipeptides: allorf_5704565_5704741_lanthipeptide

7

LLSQHPGCLSNS

18

L+S +PGCL+++

20

LVSSNPGCLASA

31

with 1 more sequence matches

16.7% NZ_QKUF01000048.1: Lanthipeptides: EI42_RS30000_lanthipeptide

12

PGCLSNST

19

PGCL+N+T

9

PGCLTNNT

16

allorf_108495_108641

Leader:

MRNGKSHLEGG

Core:

FMLRCFQHLSRPHIATQRCPWQNNWYTSGASIPVLSY

Core with dehydrations:

FMLRCysFQHLDhaRPHIADhbQRCysPWQNNWYDhbDhaGADhaIPVLDhaY

antiSMASH-DB 4.0 matches for allorf_108495_108641

100.0% NZ_CP039297.1and 3 others:

NZ_CP040672.1 Lanthipeptides: allorf_1096518_1096664_lanthipeptideNZ_CP059318.1 Lanthipeptides: allorf_0101519_0101665_lanthipeptideNZ_CP087137.1 Lanthipeptides: allorf_0101357_0101503_lanthipeptide

Lanthipeptides: allorf_0101584_0101730_lanthipeptide

1

FMLRCFQHLSRPHIATQRCPWQNNWYTSGASIPVLSY

37

FMLRCFQHLSRPHIATQRCPWQNNWYTSGASIPVLSY

1

FMLRCFQHLSRPHIATQRCPWQNNWYTSGASIPVLSY

37

24.4% NZ_CP070036.1and 2 others:

NZ_JADMPO010000043.1 Lanthipeptides: I2I27_RS16845_lanthipeptideNZ_JAQMLK010000037.1 Lanthipeptides: PNW18_RS16700_lanthipeptide

Lanthipeptides: I6K72_RS03930_lanthipeptide

2

MLRCFQHLSRPHIATQRCPWQNNW

25

M R Q LS H RC W+ +W

10

MERIKQLLS-EHSQMFRCSWRKSW

32

20.5% NZ_BMRY01000003.1and 1 other:

NZ_BMRY01000003.1 Lanthipeptides: allorf_458543_458737_lanthipeptide

Lanthipeptides: allorf_458543_458737_lanthipeptide

3

LRC-FQHLSRPHIATQRCPW

21

LRC F P + RCPW

13

LRCPFVRPPSPLLLRPRCPW

32

with 3 more sequence matches

18.9% NZ_LT630004.1: Lanthipeptides: allorf_2780249_2780374_lanthipeptide

19

CPWQNNWYTSGASIPV

34

CP++NN Y G +P+

11

CPYRNNIY--GTFLPL

24

18.0% NZ_JACKVL010000013.1: Lanthipeptides: allorf_1185244_1185420_lanthipeptide

9

LSRPHIATQRCPWQNNWYTSGASIPV

34

L R +A +R P +W TS +I +

4

LVRLAVAAKRMPAGASWTTSTGNIEI

29

13.5% NZ_LR134301.1: Lanthipeptides: allorf_1738566_1738781_lanthipeptide

19

CPWQNNWYTSG

29

CPW W G

4

CPWPGGWVVQG

14

allorf_108748_108939

Leader:

MYAYCYLVLREHSQWFGG

Core:

DSEEVTPVPMPNTEVKLFSADGSRGFSPCESRTPPSYHYGKGSSS

Core with dehydrations:

DDhaEEVDhbPVPMPNDhbEVKLFDhaADGDhaRGFDhaPCysEDhaRDhbPPDhaYHYGKGDhaDhaDha

antiSMASH-DB 4.0 matches for allorf_108748_108939

47.4% NZ_CP039297.1and 2 others:

NZ_CP040672.1 Lanthipeptides: allorf_1096771_1096998_lanthipeptideNZ_CP087137.1 Lanthipeptides: allorf_0101610_0101837_lanthipeptide

Lanthipeptides: allorf_0101837_0102064_lanthipeptide

1

DSEEVTPVPMPNTEVKLFSADGSRGFSPCE

30

DSEEVTPVPMPNTEVKLFSADGSRGF P

1

DSEEVTPVPMPNTEVKLFSADGSRGFPPVR

30

47.4% NZ_CP059318.1: Lanthipeptides: allorf_0101772_0101999_lanthipeptide

1

DSEEVTPVPMPNTEVKLFSADGSRGFSPCE

30

DSEEVTPVPMPNTEVKLFSADGSRGF P

1

DSEEVTPVPMPNTEVKLFSADGSRGFLPVR

30

22.2% NZ_CP036019.1and 1 other:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27200_lanthipeptide

Lanthipeptides: EXW52_RS27200_lanthipeptide

23

SRGFSPCESRTPPSYHYGKGSSS

45

S G CE R SY Y G S

9

SSGCGRCEPRNDSSYTYNCGGKS

31

with 3 more sequence matches

20.0% NZ_AP025692.1and 8 others:

NZ_AP025692.1 Lanthipeptides: allorf_0069478_0069666_lanthipeptideNZ_CP056773.1 Lanthipeptides: allorf_6887512_6887700_lanthipeptideNZ_CP056773.1 Lanthipeptides: allorf_6887512_6887700_lanthipeptideNZ_JAHUVY010000001.1 Lanthipeptides: allorf_0075041_0075244_lanthipeptideNZ_JAHUVY010000001.1 Lanthipeptides: allorf_0075041_0075244_lanthipeptideNZ_OX371412.1 Lanthipeptides: allorf_0056080_0056268_lanthipeptideNZ_VOGX01000034.1 Lanthipeptides: allorf_1079300_1079488_lanthipeptideNZ_VOGX01000034.1 Lanthipeptides: allorf_1079300_1079488_lanthipeptide

Lanthipeptides: allorf_0069478_0069666_lanthipeptide

28

PC-ESRTPPSYHYGKG

42

PC +RTPP H G G

8

PCGWARTPPRGHSGTG

23

20.0% NZ_QOIL01000017.1: Lanthipeptides: allorf_026474_026683_lanthipeptide

23

SRGFSPCESRTPPSYHYG

40

SR PC+ R PPS +G

2

SRLAPPCQGRRPPSACHG

19

11.1% NZ_NAQX01000046.1: Lanthipeptides: B8A46_RS06340_lanthipeptide

16

KLFSADGSRGFSPCESRT

33

K+F DG + C++++

3

KVFDLDGEENYCYCDNQS

20

allorf_108766_108915

Leader:

MIAWRRPTLTGG

Core:

KPPTTIGAEELNFRVRHGNGCDLFAIATKPLRVFSQN

Core with dehydrations:

KPPDhbDhbIGAEELNFRVRHGNGCysDLFAIADhbKPLRVFDhaQN

antiSMASH-DB 4.0 matches for allorf_108766_108915

18.9% NZ_CP060140.1and 1 other:

NZ_VIKW01000003.1 Lanthipeptides: FJR04_RS03310_lanthipeptide

Lanthipeptides: BDGGKGIB_RS05565_lanthipeptide

6

IGAEELNF

13

IGAEEL+F

18

IGAEELSF

25

18.9% NZ_VLKB01000010.1: Lanthipeptides: allorf_1593188_1593316_lanthipeptide

6

IGAEELNFRVRHGNGC

21

I A +NF + +G GC

2

IPARPINFNITNGQGC

17

10.2% NC_021055.1and 3 others:

NC_021055.1 Lanthipeptides: allorf_2673515_2673721_lanthipeptideNZ_CP038147.1 Lanthipeptides: allorf_2285811_2286017_lanthipeptideNZ_CP038147.1 Lanthipeptides: allorf_2285811_2286017_lanthipeptide

Lanthipeptides: allorf_2673515_2673721_lanthipeptide

4

TTIGAEELNFRVRHGN

19

+ +GA + +R RHG+

36

SGMGAAQAAYRTRHGS

51

allorf_108794_108976

Leader:

MVAIAKRSHPFPCRTRKLSSSAPMVVGG

Core:

FPPVRVGRRQAIITVKAAHHELPFLCFSAYVI

Core with dehydrations:

FPPVRVGRRQAIIDhbVKAAHHELPFLCysFDhaAYVI

antiSMASH-DB 4.0 matches for allorf_108794_108976

56.1% NZ_CP039297.1and 1 other:

NZ_CP087137.1 Lanthipeptides: allorf_0101610_0101837_lanthipeptide

Lanthipeptides: allorf_0101837_0102064_lanthipeptide

1

FPPVRVGRRQAIITVKAAHHELPFLCFSAYVI

32

FPPVRVGRRQAIITVKAAHHELPFLCFSAYVI

26

FPPVRVGRRQAIITVKAAHHELPFLCFSAYVI

57

54.4% NZ_CP040672.1: Lanthipeptides: allorf_1096771_1096998_lanthipeptide

1

FPPVRVGRRQAIITVKAAHHELPFLCFSAYVI

32

FPPVRVGRRQAII+VKAAHHELPFLCFSAYVI

26

FPPVRVGRRQAIISVKAAHHELPFLCFSAYVI

57

54.4% NZ_CP059318.1: Lanthipeptides: allorf_0101772_0101999_lanthipeptide

1

FPPVRVGRRQAIITVKAAHHELPFLCFSAYVI

32

F PVRVGRRQAIITVKAAHHELPFLCFSAYVI

26

FLPVRVGRRQAIITVKAAHHELPFLCFSAYVI

57

allorf_108936_109136

Leader:

MSCLFCVFLHTLYNM

Core:

RNVTICLFAKAGFMLVQSGNNRDRAIQLKNFAKHLIVRLKSNIVKVNEGGG

Core with dehydrations:

RNVDhbICysLFAKAGFMLVQDhaGNNRDRAIQLKNFAKHLIVRLKDhaNIVKVNEGGG

antiSMASH-DB 4.0 matches for allorf_108936_109136

100.0% NZ_CP059318.1: Lanthipeptides: allorf_0101959_0102159_lanthipeptide

1

RNVTICLFAKAGFMLVQSGNNRDRAIQLKNFAKHLIVRLKSNIVKVNEGGG

51

RNVTICLFAKAGFMLVQSGNNRDRAIQLKNFAKHLIVRLKSNIVKVNEGGG

1

RNVTICLFAKAGFMLVQSGNNRDRAIQLKNFAKHLIVRLKSNIVKVNEGGG

51

98.0% NZ_CP039297.1: Lanthipeptides: allorf_0102024_0102224_lanthipeptide

1

RNVTICLFAKAGFMLVQSGNNRDRAIQLKNFAKHLIVRLKSNIVKVNEGGG

51

RNVTICLFAKAGFMLVQSGNNRDRAIQLKNFAKHLIVRLKSNIVKVN+GGG

1

RNVTICLFAKAGFMLVQSGNNRDRAIQLKNFAKHLIVRLKSNIVKVNKGGG

51

96.1% NZ_CP040378.1: Lanthipeptides: allorf_0072224_0072424_lanthipeptide

1

RNVTICLFAKAGFMLVQSGNNRDRAIQLKNFAKHLIVRLKSNIVKVNEGGG

51

RNVTICLFAKAGFMLVQSGNNRDRAIQLKNFAKH IVRLKSNIVKVN+GGG

1

RNVTICLFAKAGFMLVQSGNNRDRAIQLKNFAKHFIVRLKSNIVKVNKGGG

51

with 4 more sequence matches

96.1% NZ_CP040672.1: Lanthipeptides: allorf_1096958_1097158_lanthipeptide

1

RNVTICLFAKAGFMLVQSGNNRDRAIQLKNFAKHLIVRLKSNIVKVNEGGG

51

RNVTICLFAKAGFMLVQSGNNRDRAIQLKNFAK LIVRLKSNIVKVN+GGG

1

RNVTICLFAKAGFMLVQSGNNRDRAIQLKNFAKRLIVRLKSNIVKVNKGGG

51

15.7% NZ_CP011130.1: Lanthipeptides: allorf_4095947_4096132_lanthipeptide

9

AKAGFMLVQSGNNRDR

24

AKA + +SG +RDR

9

AKATWPTCRSGASRDR

24

15.7% NZ_CP023465.1: Lanthipeptides: allorf_4137774_4138001_lanthipeptide

9

AKAGFMLVQSGNNRDRAI

26

A+A + +SG +RDR I

8

AEATWPTCRSGASRDRDI

25

11.3% NZ_VITV01000003.1: Lanthipeptides: FBZ87_RS11200_lanthipeptide

6

CLFAKAGFMLV

16

C AKAGFM++

49

CDSAKAGFMVI

59

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

ctg1_108 - Class II

Cleavage pHMM score: -3.30

RODEO score: 0

Monoisotopic mass: 3716.1 Da

Molecular weight: 3718.5 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3736.5 Da N = 1; 3754.5 Da N = 2; 3772.5 Da N = 3; 3790.6 Da N = 4

allorf_105014_105088 - Class II

Cleavage pHMM score: -3.80

RODEO score: 0

Monoisotopic mass: 1477.8 Da

Molecular weight: 1478.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1496.7 Da N = 1; 1514.7 Da N = 2

allorf_105836_105952 - Class II

Cleavage pHMM score: -6.20

RODEO score: 0

Monoisotopic mass: 2152.1 Da

Molecular weight: 2153.4 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2171.4 Da N = 1; 2189.4 Da N = 2; 2207.4 Da N = 3

allorf_106877_107011 - Class II

Cleavage pHMM score: -6.80

RODEO score: 0

Monoisotopic mass: 2525.3 Da

Molecular weight: 2526.9 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2544.9 Da N = 1; 2562.9 Da N = 2; 2580.9 Da N = 3; 2599.0 Da N = 4; 2617.0 Da N = 5; 2635.0 Da N = 6

allorf_108495_108641 - Class II

Cleavage pHMM score: -5.00

RODEO score: 0

Monoisotopic mass: 4299.1 Da

Molecular weight: 4301.9 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4319.9 Da N = 1; 4337.9 Da N = 2; 4356.0 Da N = 3; 4374.0 Da N = 4

allorf_108748_108939 - Class II

Cleavage pHMM score: -3.20

RODEO score: 0

Monoisotopic mass: 4600.2 Da

Molecular weight: 4602.9 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 4620.9 Da N = 1; 4639.0 Da N = 2; 4657.0 Da N = 3; 4675.0 Da N = 4; 4693.0 Da N = 5; 4711.0 Da N = 6; 4729.1 Da N = 7; 4747.1 Da N = 8; 4765.1 Da N = 9; 4783.1 Da N = 10; 4801.1 Da N = 11

allorf_108766_108915 - Class II

Cleavage pHMM score: -4.60

RODEO score: 0

Monoisotopic mass: 4024.1 Da

Molecular weight: 4026.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 4044.6 Da N = 1; 4062.6 Da N = 2; 4080.6 Da N = 3

allorf_108794_108976 - Class II

Cleavage pHMM score: -4.90

RODEO score: 0

Monoisotopic mass: 3599.0 Da

Molecular weight: 3601.3 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3619.3 Da N = 1

allorf_108936_109136 - Class II

Cleavage pHMM score: -5.60

RODEO score: 0

Monoisotopic mass: 5583.1 Da

Molecular weight: 5586.5 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 5604.6 Da N = 1; 5622.6 Da N = 2

gnlProkkaMDFAHGHL_2 - Region 1 - NRPS,betalactone,transAT-PKS

Download region GenBank file

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Location: 81,859 - 219,690 nt. (total: 137,832 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

NRPS/PKS domains

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

Show module domains

Similar known gene clusters from MIBiG 3.1

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 81858 - 219690:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Glu - D-Orn) + (D-Thr) + (Glu - D-X) + (Pro - Gln) + (Ile) + (mal - Asn) + (D-Tyr - D-Asn - Pro - Glu) + (Ser) + (Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 81858 - 159110:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal - Asn) + (D-Tyr - D-Asn - Pro - Glu) + (Ser) + (Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 142021 - 219690:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Glu - D-Orn) + (D-Thr) + (Glu - D-X) + (Pro - Gln) + (Ile)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg2_112

Search NORINE for peptide: strict or relaxed

AMP-binding (819..1218): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg2_113

Search NORINE for peptide: strict or relaxed

AMP-binding (267..674): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHFSLIDK
Nearest Stachelhaus code(s):: Ser DVWHFSLIDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg2_114

Search NORINE for peptide: strict or relaxed

AMP-binding (268..662): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: DALSVGEVVK
Nearest Stachelhaus code(s):: Tyr DALSVGEVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1779..2174): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKIGEVGK
Nearest Stachelhaus code(s):: Asn DLTKIGEVGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3286..3683): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DVQFIAHVVK
Nearest Stachelhaus code(s):: Pro DVQFIAHVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4325..4732): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: gln (Gln)

Stachelhaus prediction details:

Stachelhaus sequence:: DAKDLGVVDK
Nearest Stachelhaus code(s):: Glu DAKDLGVVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg2_115

Search NORINE for peptide: strict or relaxed

CAL_domain (36..478): pk

minowa: fatty_acid

Prediction, score:

fatty_acid: 623.2
NH2: 18.6
shikimic_acid: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0

AMP-binding (2956..3351): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKIGEVGK
Nearest Stachelhaus code(s):: Asn DLTKIGEVGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg2_116

PKS_AT (6..290): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 75.7
inactive: 30.0
Methoxymalonyl-CoA: 20.4
Propionyl-CoA: 11.8
Methylmalonyl-CoA: 11.0
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

ctg2_135

AMP-binding (12..445): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: -GLHIAAPVK
Nearest Stachelhaus code(s):: Z-ahmohOrn FGLHIASTCK (56% 8Å match); Ile DGLFIGIPVK (32% 8Å match)
Stachelhaus code match:: 60% (weak)

ctg2_139

Search NORINE for peptide: strict or relaxed

AMP-binding (473..866): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: ile (Ile)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFFYGITFK
Nearest Stachelhaus code(s):: Ile DAFFYGITFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg2_141

Search NORINE for peptide: strict or relaxed

AMP-binding (469..866): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DVQFIAHVVK
Nearest Stachelhaus code(s):: Pro DVQFIAHVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1500..1901): Gln

nrpys: Gln

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: glu (Glu)

Stachelhaus prediction details:

Stachelhaus sequence:: DAWHFGSVEK
Nearest Stachelhaus code(s):: Gln DAWHFGSVEK (100% 8Å match); Glu DAWHFGSVEK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2532..2924): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: DGTITAEVAK
Nearest Stachelhaus code(s):: Tyr DGTITAEVAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg2_142

Search NORINE for peptide: strict or relaxed

AMP-binding (468..873): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: glu (Glu)

Stachelhaus prediction details:

Stachelhaus sequence:: DAWHFGGVDK
Nearest Stachelhaus code(s):: Glu DAWHFGGVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1505..1898): X

nrpys: Ala, Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DVFWIGGTFK
Nearest Stachelhaus code(s):: Ala or Val DVFWIGGTFK (100% 8Å match); Val DVFWIGGTFK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg2_143

Search NORINE for peptide: strict or relaxed

AMP-binding (831..1227): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg2_145

Search NORINE for peptide: strict or relaxed

AMP-binding (2..253): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: glu (Glu)

Stachelhaus prediction details:

Stachelhaus sequence:: DAWHFGGVDK
Nearest Stachelhaus code(s):: Glu DAWHFGGVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (885..1290): Orn

nrpys: Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: DVGEVGSIDK
Nearest Stachelhaus code(s):: Orn DVGEVGSIDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

gnlProkkaMDFAHGHL_3 - Region 1 - terpene

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Location: 8,210 - 30,093 nt. (total: 21,884 nt) Show pHMM detection rules used

Region on contig edge.

terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

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No matches found.

gnlProkkaMDFAHGHL_5 - Region 1 - T3PKS

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Location: 895 - 42,139 nt. (total: 41,245 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

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NRPS/PKS substrates

NRPS/PKS substrate predictions

gnlProkkaMDFAHGHL_5 - Region 2 - transAT-PKS

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Location: 159,479 - 263,800 nt. (total: 104,322 nt) Show pHMM detection rules used

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

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Detailed domain annotation

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 2, location 159478 - 263800:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (ohmal) + (ccmal) + (ohmal - mal) + (Me-ccmal) + (mal) + (Me-ccmal) + (mal) + (ccmal) + (mal) + (ohmal - mal)
Non-colinear ordering:: ctg5_220 + ctg5_219 + ctg5_218 + ctg5_217 + ctg5_216 + ctg5_215 + ctg5_228 + ctg5_223 + ctg5_222 + ctg5_226 + ctg5_225 + ctg5_224

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg5_230

AMP-binding (15..363): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: IGNPTGTIFK
Nearest Stachelhaus code(s):: 2,3-dohHda IGNPTGTIMK (76% 8Å match)
Stachelhaus code match:: 90% (moderate)

ctg5_234

PKS_AT (4..281): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 87.7
inactive: 30.9
Methoxymalonyl-CoA: 29.3
Methylmalonyl-CoA: 21.7
Propionyl-CoA: 16.5
2-Methylbutyryl-CoA: 15.4
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

gnlProkkaMDFAHGHL_7 - Region 1 - NRP-metallophore,NRPS,RiPP-like

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Location: 65,773 - 117,560 nt. (total: 51,788 nt) Show pHMM detection rules used

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX))
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 65772 - 117560:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly) + (Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 65772 - 117507:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly) + (Thr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg7_94

Search NORINE for peptide: strict or relaxed

AMP-binding (392..808): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg7_95

Search NORINE for peptide: strict or relaxed

AMP-binding (456..855): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: DILQLGLIWK
Nearest Stachelhaus code(s):: Gly DILQLGLIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg7_97

Search NORINE for peptide: strict or relaxed

AMP-binding (31..435): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: PLPAQGVVNK
Nearest Stachelhaus code(s):: diOH-Bz PLPAQGVVNK (100% 8Å match); diOH-Bz or Sal PLPAQGVVNK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

gnlProkkaMDFAHGHL_8 - Region 1 - other

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Location: 502,321 - 543,739 nt. (total: 41,419 nt) Show pHMM detection rules used

other: (LmbU or Neocarzinostat or bcpB or frbD or mitE or vlmB or prnB or CaiA or bacilysin or orf2_PTase)

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gnlProkkaMDFAHGHL_9 - Region 1 - NRPS

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Location: 11,832 - 77,240 nt. (total: 65,409 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

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Predicted core structure(s)

For candidate cluster 1, location 11831 - 77240:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Glu - Leu - Leu) + (Val) + (Asp - D-Leu) + (Leu)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg9_32

Search NORINE for peptide: strict or relaxed

AMP-binding (465..867): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: gln (Gln)

Stachelhaus prediction details:

Stachelhaus sequence:: DAKDLGVVDK
Nearest Stachelhaus code(s):: Glu DAKDLGVVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1511..1908): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFMMGMVFK
Nearest Stachelhaus code(s):: Leu DAFMMGMVFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2550..2939): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: DAWFLGNVVK
Nearest Stachelhaus code(s):: Leu DAWFLGNVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg9_35

Search NORINE for peptide: strict or relaxed

AMP-binding (470..864): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWIGGTFK
Nearest Stachelhaus code(s):: Val DAFWIGGTFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg9_36

Search NORINE for peptide: strict or relaxed

AMP-binding (112..514): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asp (Asp)

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKVGHIGK
Nearest Stachelhaus code(s):: Asp DLTKVGHIGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1157..1546): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: DAWFLGNVVK
Nearest Stachelhaus code(s):: Leu DAWFLGNVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg9_37

Search NORINE for peptide: strict or relaxed

AMP-binding (469..867): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFFLGCVFK
Nearest Stachelhaus code(s):: Leu DAFFLGCVFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

gnlProkkaMDFAHGHL_14 - Region 1 - PKS-like

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Location: 175,458 - 216,702 nt. (total: 41,245 nt) Show pHMM detection rules used

PKS-like: (t2pks2 or ksIII)

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NRPS/PKS domains

KnownClusterBlast

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

Show module domains

Similar known gene clusters from MIBiG 3.1

gnlProkkaMDFAHGHL_14 - Region 2 - terpene

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Location: 299,485 - 320,225 nt. (total: 20,741 nt) Show pHMM detection rules used

terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

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core biosynthetic genes

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaMDFAHGHL_16 - Region 1 - transAT-PKS

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Location: 133,835 - 222,063 nt. (total: 88,229 nt) Show pHMM detection rules used

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

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core biosynthetic genes

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NRPS/PKS domains

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 133834 - 222063:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (ohmal - ccmal) + (ccmal - mal) + (ohmal) + (ohmal - mal) + (ccmal) + (mal)
Non-colinear ordering:: ctg16_168 + ctg16_169 + ctg16_175 + ctg16_176 + ctg16_177 + ctg16_178 + ctg16_173 + ctg16_174

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg16_167

PKS_AT (4..282): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 91.9
inactive: 31.2
Methoxymalonyl-CoA: 26.1
Methylmalonyl-CoA: 19.6
Propionyl-CoA: 16.9
fatty_acid: 13.9
trans-1,2-CPDA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

gnlProkkaMDFAHGHL_16 - Region 2 - NRPS,NRPS-like,T3PKS,transAT-PKS

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Location: 443,342 - 536,922 nt. (total: 93,581 nt) Show pHMM detection rules used

Region on contig edge.

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
NRPS: cds(Condensation and (AMP-binding or A-OX))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 2, location 443341 - 536922:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - ccmal - ohmal - mal) + (ccmal - mal - ohmal - mal) + (Me-ccmal - ohmal) + (Ala - ccmal - ccmal - Me-ccmal) + (mal - mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg16_440

PKS_AT (4..285): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 100.0
inactive: 46.8
Methoxymalonyl-CoA: 38.9
Methylmalonyl-CoA: 25.3
Propionyl-CoA: 23.1
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

ctg16_441

PKS_AT (7..293): mal

ATSignature: (unknown)

No matches above 50%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 31.9
inactive: 26.1
Methoxymalonyl-CoA: 16.2
Benzoyl-CoA: 14.0
Methylmalonyl-CoA: 9.1
Isobutyryl-CoA: 8.8
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

ctg16_442

PKS_AT (4..282): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 89.6
inactive: 28.2
Methoxymalonyl-CoA: 21.6
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

ctg16_448

Search NORINE for peptide: strict or relaxed

CAL_domain (0..396): pk

minowa: fatty_acid

Prediction, score:

fatty_acid: 23.9
NH2: 9.4
shikimic_acid: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0

AMP-binding (1065..1460): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: DILQLGMIWK
Nearest Stachelhaus code(s):: Gly DILQLGMIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg16_452

Search NORINE for peptide: strict or relaxed

AMP-binding (173..577): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVSNMAIIYK
Nearest Stachelhaus code(s):: Ala DVSNMAIIYK (88% 8Å match)
Stachelhaus code match:: 100% (strong)