GCA_020978285.1 - 3 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaFCICFAKG_1 (original name was: gnl|Prokka|FCICFAKG_1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	T3PKS	394,142	435,299

gnlProkkaFCICFAKG_2 (original name was: gnl|Prokka|FCICFAKG_2)

Region	Type	From	To	Most similar known cluster		Similarity
Region 2.1	lanthipeptide-class-ii,RiPP-like	67,868	90,810
Region 2.2	arylpolyene	136,250	166,020

Region	Type	From	To	Similarity
Region 1.1	T3PKS	394,142	435,299
Region 2.1	lanthipeptide-class-ii,RiPP-like	67,868	90,810
Region 2.2	arylpolyene	136,250	166,020

Compact view

gnlProkkaFCICFAKG_1 - Region 1 - T3PKS

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Location: 394,142 - 435,299 nt. (total: 41,158 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaFCICFAKG_2 - Region 1 - RiPP-like,lanthipeptide-class-ii

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Location: 67,868 - 90,810 nt. (total: 22,943 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

Lanthipeptide predictions

Lanthipeptide(s) for ctg2_81

ctg2_79

Leader:

MDKEELEKIVGNNFEEMSLQKMTEIQGM

Core:

GEYQVDSTPAASAISRATIQVSRASSGKCLSWGSGAAFSAYFTHKRWC

Core with dehydrations:

GEYQVDDhaDhbPAADhaAIDhaRADhbIQVDhaRADhaDhaGKCysLDhaWGDhaGAAFDhaAYFDhbHKRWCys

antiSMASH-DB 4.0 matches for ctg2_79

33.3% NZ_CP045729.1: Lanthipeptides: LG045_RS07910_lanthipeptide

1

GEYQVDSTPAASAISRATIQVSRASSGKCLSW

32

G STPA ISR T+ ++R SS KC+SW

1

GTETAQSTPA---ISRVTLSIARKSSAKCISW

29

31.2% NZ_CP026035.1: Lanthipeptides: C2H96_RS00305_lanthipeptide

8

TPAASAISRATIQVSRASSGKCLSWGSGAAFSAYFTHKRWC

48

TPA SA+ A + +R C+S G G+A S +H + C

8

TPAVSAVLSAVGRSTRL----CIS-GIGSAISGIVSHNKDC

43

31.2% NZ_CP094446.1: Lanthipeptides: L3476_RS23825_lanthipeptide

2

EYQVDSTPA--ASAISRATIQVSRASSGKCLSWGSGAAFSAYFTHKRWC

48

+ + TPA SA++R SS C+S G+A S +H + C

2

DVEPRGTPATIVSAVTR--------SSKPCIS-AIGSAISGIISHNKDC

41

with 15 more sequence matches

27.1% NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

1

GEYQVDSTPAASAISRATIQV--SRASSGKCLS

31

G+ ++TPA I ATI V S + KC S

1

GDVNPETTPATPTIIGATIAVTASLCPTTKCTS

33

27.1% NZ_CP015591.1and 15 others:

NZ_CP078085.1 Lanthipeptides: KU891_RS29355_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29350_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29345_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29340_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29335_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptide

Lanthipeptides: A7A70_RS27550_lanthipeptide

1

GEYQVDSTPAASAISRATI--QVSRASSGKCLS

31

G+ ++TPA I ATI VS + KC S

1

GDVNPETTPATPTIVEATIAATVSICPTTKCTS

33

27.1% NZ_KB976303.1and 1 other:

NZ_KB976303.1 Lanthipeptides: IGY_RS26035_lanthipeptide

Lanthipeptides: IGY_RS26045_lanthipeptide

18

TIQVSRASSGKCLSWGSGAAFSAYFTHKRWC

48

I VSRASS C+S S A S ++ + C

11

VIVVSRASSKACMSGVS--AISGLLSYNKDC

39

27.1% NZ_KN125582.1: Lanthipeptides: DJ91_RS27550_lanthipeptide

19

IQVSRASSGKCLSWGSGAAFSAYFTHKRWC

48

I VSR SS KC S S A S ++ + C

12

IVVSRISSAKCASTIS--AISGLVSYNKDC

39

25.0% NZ_CP045729.1: Lanthipeptides: allorf_1568662_1568871_lanthipeptide

10

AASAISRATIQVSRASSGKCLSWGSGAAFSAYFTHKR

46

A SA + I +S+ASS +C W S + ++ H +

8

AESAQTSPLIPISKASSVRCAKWVSAISGLSWAKHHK

44

22.9% NZ_CP099547.1: Lanthipeptides: allorf_0559994_0560212_lanthipeptide

1

GEYQVDSTPAASAISRATIQVSRASSGKCLSW

32

G ++TP + S VS+A SG +SW

2

GGITPNATPTVTTSSVPCATVSKAVSGALVSW

33

20.8% NZ_NVMQ01000017.1: Lanthipeptides: CON32_RS17795_lanthipeptide

9

PAASAISRATIQVSRASSGKC

29

P SR T+Q S+ASS C

9

PTVVVASRITVQASKASSKSC

29

20.0% NZ_JAQCQD010000003.1: Lanthipeptides: PGZ38_RS05485_lanthipeptide

1

GEYQVDSTPAASAISRATIQVSRASSGKC

29

G+ + TP A + I +RASS C

1

GDMSAELTPTTPACFASIIYTARASSPNC

29

20.0% NZ_QSIO01000003.1: Lanthipeptides: DW820_RS07290_lanthipeptide

1

GEYQVDSTPAASAISRATIQVSRASSGKC

29

G+ + TP A + I +RASS C

1

GDMSAEFTPTTPACFASIIYTARASSASC

29

18.8% NZ_FPCC01000026.1: Lanthipeptides: BM377_RS12935_lanthipeptide

1

GEYQVDSTPAASAIS----------RATIQVSRASSGKC

29

G+ ++TPA + + AT++V++ +G C

1

GDVDAETTPAITVSAAVVIGGSLGFEATVKVTKTCNGNC

39

18.8% NZ_JADMPO010000001.1: Lanthipeptides: I2I27_RS01390_lanthipeptide

7

STP--AASAISRATIQVSRASSGKC

29

+TP A + + +IQV++ GKC

8

TTPICAVAVTASLSIQVAKTLKGKC

32

16.7% NZ_VTZW01000015.1: Lanthipeptides: allorf_204916_205050_lanthipeptide

32

WGSGAAFSAYFTH

44

W G AFS YF H

8

WERGEAFSDYFDH

20

16.2% NZ_MOWR01000001.1: Lanthipeptides: allorf_319458_319697_lanthipeptide

3

YQVDSTPAASAISRATIQVSRASSGKCLSWGSGAAFSA

40

+Q ++T ++SRA V+ S C +W S + A

24

FQTNNT----SVSRAFFAVTATMSAACQNWSSQKNYPA

57

15.3% NZ_OAOR01000001.1and 1 other:

NZ_OAOR01000001.1 Lanthipeptides: allorf_0316623_0316829_lanthipeptide

Lanthipeptides: allorf_0316623_0316829_lanthipeptide

28

KCLSWGSGAAFSAYFTH

44

+C G GAA +AY TH

32

RCFRSGMGAAQAAYRTH

48

12.5% NZ_SDJV01000024.1and 1 other:

NZ_SDJV01000024.1 Lanthipeptides: ES032_RS12705_lanthipeptide

Lanthipeptides: ES032_RS12700_lanthipeptide

1

GEYQVDSTPA

10

G+ QV++TPA

1

GDVQVETTPA

10

allorf_085809_085901

Leader:

MRVAHKQSPLAIDYDCQGA

Core:

LFVLVILLCFT

Core with dehydrations:

LFVLVILLCysFDhb

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

ctg2_79 - Class II

Cleavage pHMM score: -2.10

RODEO score: 0

Monoisotopic mass: 4879.4 Da

Molecular weight: 4882.4 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4900.4 Da N = 1; 4918.4 Da N = 2; 4936.4 Da N = 3; 4954.4 Da N = 4; 4972.5 Da N = 5; 4990.5 Da N = 6; 5008.5 Da N = 7; 5026.5 Da N = 8; 5044.5 Da N = 9; 5062.6 Da N = 10

allorf_085809_085901 - Class II

Cleavage pHMM score: -4.50

RODEO score: 0

Monoisotopic mass: 1261.8 Da

Molecular weight: 1262.6 Da

Number of bridges: 1

gnlProkkaFCICFAKG_2 - Region 2 - arylpolyene

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Location: 136,250 - 166,020 nt. (total: 29,771 nt) Show pHMM detection rules used

Region on contig edge.

arylpolyene: (APE_KS1 or APE_KS2)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

Gene overview

NRPS/PKS domains

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

Show module domains

Similar known gene clusters from MIBiG 3.1

No matches found.

NRPS/PKS substrates

NRPS/PKS substrate predictions

ctg2_154

PKS_AT (5..284): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%

minowa: inactive

Prediction, score:

inactive: 28.9
Malonyl-CoA: 25.1
Methoxymalonyl-CoA: 9.9
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0