GCA_025148125.1 - 11 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaEDPMNEJH_1 (original name was: gnl|Prokka|EDPMNEJH_1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	cyclic-lactone-autoinducer	658,078	678,946
Region 2	lanthipeptide-class-ii,ranthipeptide	882,564	919,690	ruminococcin A	RiPP:Lanthipeptide	14%
Region 3	cyclic-lactone-autoinducer	1,136,659	1,163,133
Region 4	cyclic-lactone-autoinducer	1,213,997	1,234,401
Region 5	cyclic-lactone-autoinducer	1,314,506	1,335,236
Region 6	cyclic-lactone-autoinducer	1,465,636	1,486,369
Region 7	NRPS	1,897,541	1,946,525	dipeptide aldehydes	NRP	82%
Region 8	cyclic-lactone-autoinducer	2,164,991	2,185,560
Region 9	lanthipeptide-class-ii	2,189,041	2,212,007	xantholipin	Polyketide	6%
Region 10	ranthipeptide	2,715,265	2,736,853
Region 11	lanthipeptide-class-ii	3,300,589	3,323,282

gnlProkkaEDPMNEJH_1 - Region 1 - cyclic-lactone-autoinducer

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Location: 658,078 - 678,946 nt. (total: 20,869 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaEDPMNEJH_1 - Region 2 - lanthipeptide-class-ii,ranthipeptide

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Location: 882,564 - 919,690 nt. (total: 37,127 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

Lanthipeptide predictions

Lanthipeptide(s) for ctg1_785

ctg1_784

Leader:

MKKNYRNPMTRPENFMNPAGNVMKEIKEADLNNFSAGAGEPRVSDGS

Core:

QFCTSTKECNWGTIMFVCC

Core with dehydrations:

QFCysDhbDhaDhbKECysNWGDhbIMFVCysCys

MIBiG 3.1 matches for ctg1_784

26.3% BGC0000503 (cinA): Lanthipeptide: cinnamycin

7

KECNWGTIMFVC

18

+ C++G FVC

3

QSCSFGPFTFVC

14

20.0% BGC0002110 (QKV49893.1): Lanthipeptide: birimositide

2

FCTSTKEC

9

+CT TKEC

18

WCTLTKEC

25

17.9% BGC0000517 (BAB04173.1): Lanthipeptide: haloduracin β or haloduracin α

2

FCTSTKEC

9

+CT T EC

16

YCTLTVEC

23

with 3 more sequence matches

13.6% BGC0000553 (SSGG_RS09925): Lanthipeptide: SRO15-2212

9

CNWGTIMFVCC

19

C + ++ V C

10

CEYSSLSVVLC

20

12.8% BGC0001229 (SBI_06990): Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

3

CTSTKEC

9

CT +KEC

28

CTLSKEC

34

10.8% BGC0001229 (SBI_06989)and 1 other:

BGC0002110 (QKV49894.1) Lanthipeptide: birimositide

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

2

FCTSTK

7

FC +TK

27

FCPTTK

32

antiSMASH-DB 4.0 matches for ctg1_784

100.0% NZ_CP102267.1and 11 others:

NZ_FMUW01000051.1 Lanthipeptides: BLP57_RS16830_lanthipeptideNZ_JAQDBP010000004.1 Lanthipeptides: PGY07_RS07130_lanthipeptideNZ_JAQEHQ010000024.1 Lanthipeptides: PGR68_RS13915_lanthipeptideNZ_JAQESL010000043.1 Lanthipeptides: PG840_RS15980_lanthipeptideNZ_JAQESS010000001.1 Lanthipeptides: PG808_RS00050_lanthipeptideNZ_LN913006.1 Lanthipeptides: BN3261_RS01470_lanthipeptideNZ_QRPQ01000011.1 Lanthipeptides: DWZ74_RS14610_lanthipeptideNZ_QRZZ01000003.1 Lanthipeptides: DWV87_RS03120_lanthipeptideNZ_QSJW01000012.1 Lanthipeptides: DW767_RS16305_lanthipeptideNZ_QSKF01000004.1 Lanthipeptides: DW740_RS06255_lanthipeptideNZ_QUJJ01000004.1 Lanthipeptides: DW748_RS03580_lanthipeptide

Lanthipeptides: NQ550_RS04155_lanthipeptide

1

QFCTSTKECNWGTIMFVCC

19

QFCTSTKECNWGTIMFVCC

1

QFCTSTKECNWGTIMFVCC

19

42.9% NZ_QRHZ01000008.1and 2 others:

NZ_QSRF01000021.1 Lanthipeptides: DXC87_RS15310_lanthipeptideNZ_QUEQ01000033.1 Lanthipeptides: DXA48_RS19000_lanthipeptide

Lanthipeptides: DW272_RS13830_lanthipeptide

2

FCTSTKECNWGTIMFVCC

19

FCTST ECN GT+ CC

11

FCTSTGECNMGTLNIFCC

28

40.0% NZ_JAFCGV010000005.1: Lanthipeptides: JQI09_RS04275_lanthipeptide

4

TSTKECNWGTIMFVCC

19

T+T EC GT FVCC

7

TATSECYLGTFAFVCC

22

with 18 more sequence matches

40.0% NZ_WBPF01000002.1: Lanthipeptides: F8162_RS00195_lanthipeptide

1

QFCTSTKECNWGT--IMFVCC

19

QF T + EC+W T +F CC

4

QFDTISHECHWNTWQFLFTCC

24

36.0% NZ_CP045267.1and 1 other:

NZ_CP045267.1 Lanthipeptides: FDZ14_RS00155_lanthipeptide

Lanthipeptides: FDZ14_RS00155_lanthipeptide

4

TSTKECNWGTIMFVCC

19

T+T EC GT F CC

7

TATSECYLGTFAFACC

22

34.6% NZ_CP117876.1: Lanthipeptides: PQ460_RS01735_lanthipeptide

4

TSTKECNWGTIMFVCC

19

T+T EC GT+ F+CC

7

TATSECYLGTVAFICC

22

33.3% NZ_CYXV01000003.1: Lanthipeptides: ARB75_RS04585_lanthipeptide

3

CTSTKECNWGTIMFVCC

19

CT T ECN GT + CC

12

CTLTGECNIGTHIKFCC

28

29.2% NC_012470.1and 42 others:

NZ_CAAHGW010000010.1 Lanthipeptides: E9435_RS08895_lanthipeptideNZ_CAAHHE010000002.1 Lanthipeptides: E9499_RS02930_lanthipeptideNZ_CAAHHF010000009.1 Lanthipeptides: E9478_RS08675_lanthipeptideNZ_CAAHHN010000003.1 Lanthipeptides: E9502_RS05705_lanthipeptideNZ_CAAHHU010000009.1 Lanthipeptides: E9510_RS08735_lanthipeptideNZ_CAAHHW010000012.1 Lanthipeptides: E9525_RS08985_lanthipeptideNZ_CAAHIB010000001.1 Lanthipeptides: E9539_RS01075_lanthipeptideNZ_CAAHIV010000024.1 Lanthipeptides: E9612_RS09255_lanthipeptideNZ_CAAHKK010000019.1 Lanthipeptides: E9649_RS08770_lanthipeptideNZ_CAAHKP010000014.1 Lanthipeptides: E9652_RS08920_lanthipeptideNZ_CAAHKQ010000003.1 Lanthipeptides: E9664_RS02160_lanthipeptideNZ_CAAHKY010000014.1 Lanthipeptides: E9668_RS09650_lanthipeptideNZ_CAAHLP010000002.1 Lanthipeptides: E9684_RS03445_lanthipeptideNZ_CAAHQE010000012.1 Lanthipeptides: E9931_RS08815_lanthipeptideNZ_CAAHRY010000002.1 Lanthipeptides: E9986_RS03175_lanthipeptideNZ_CAAIES010000002.1 Lanthipeptides: FAH15_RS02475_lanthipeptideNZ_CAAIIA010000012.1 Lanthipeptides: FAH55_RS08475_lanthipeptideNZ_CAAIJM010000015.1 Lanthipeptides: FAI23_RS09585_lanthipeptideNZ_CAAINV010000013.1 Lanthipeptides: FAI86_RS09025_lanthipeptideNZ_CAAIRS010000012.1 Lanthipeptides: FAK24_RS08485_lanthipeptideNZ_CAAJFI010000013.1 Lanthipeptides: FAP60_RS08495_lanthipeptideNZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS10120_lanthipeptideNZ_CP018188.1 Lanthipeptides: BSR19_RS11185_lanthipeptideNZ_CP029398.1 Lanthipeptides: DF184_RS05190_lanthipeptideNZ_CP035426.1 Lanthipeptides: ETT73_RS02600_lanthipeptideNZ_CP035437.1 Lanthipeptides: ETT62_RS06670_lanthipeptideNZ_CP035443.1 Lanthipeptides: ETT56_RS07260_lanthipeptideNZ_CP066093.1 Lanthipeptides: I6I02_RS07305_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09825_lanthipeptideNZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05340_lanthipeptideNZ_JALDUD010000010.1 Lanthipeptides: M1G10_RS09695_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09305_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09305_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06590_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06590_lanthipeptideNZ_KV832031.1 Lanthipeptides: HMPREF2637_RS10860_lanthipeptideNZ_LR738724.1 Lanthipeptides: GPW69_RS05070_lanthipeptideNZ_LS483425.1 Lanthipeptides: DQN36_RS06745_lanthipeptideNZ_NWMU01000024.1 Lanthipeptides: CO197_RS09155_lanthipeptideNZ_PKIA01000004.1 Lanthipeptides: CYK22_RS04325_lanthipeptideNZ_VMMF01000004.1 Lanthipeptides: HT717_RS01580_lanthipeptideNZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05570_lanthipeptide

Lanthipeptides: SZO_RS10260_lanthipeptide

4

TSTKECNWGTI--MFVCC

19

T + EC W ++ +F CC

7

TISAECRWNSLQAIFTCC

24

29.2% NZ_ALSD01000046.1and 5 others:

NZ_CAJHJS010000009.1 Lanthipeptides: JMX87_RS06795_lanthipeptideNZ_CM001076.1 Lanthipeptides: SDD27957_RS10995_lanthipeptideNZ_GL636070.1 Lanthipeptides: HMPREF9171_RS1000000113590_lanthipeptideNZ_LR793258.1 Lanthipeptides: HV369_RS03150_lanthipeptideNZ_LT545678.1 Lanthipeptides: BJR96_RS11590_lanthipeptide

Lanthipeptides: SAG0161_RS1000000124770_lanthipeptide

4

TSTKECNWGTI--MFVCC

19

T + EC W ++ +F CC

7

TISAECRWNSLQAIFSCC

24

27.6% NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide

Lanthipeptides: EG886_RS06310_lanthipeptide

1

QFCTSTKEC

9

QFCT TKEC

15

QFCTLTKEC

23

26.3% NZ_CP059557.1: Lanthipeptides: H2Q94_RS19875_lanthipeptide

7

KECNWGTIMFVC

18

+ C+WG + VC

3

QSCSWGPVTAVC

14

25.0% NC_021362.1and 29 others:

NC_021362.1 Lanthipeptides: BALI_RS00925_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide

Lanthipeptides: BALI_RS00925_lanthipeptide

1

QFCTSTKEC

9

Q+CT TKEC

15

QWCTLTKEC

23

24.1% NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06305_lanthipeptide

Lanthipeptides: EG886_RS06305_lanthipeptide

1

QFCTSTKEC

9

+FCT TKEC

15

RFCTLTKEC

23

21.6% NZ_CP016767.1: Lanthipeptides: BCV50_RS18735_lanthipeptide

1

QFCTSTKECNWGTI

14

Q+CT + EC +GTI

21

QYCTVSAEC-FGTI

33

20.6% NZ_JAESIP010000017.1and 3 others:

NZ_LT907978.1 Lanthipeptides: EHLA_RS12685_lanthipeptideNZ_QRYY01000029.1 Lanthipeptides: DWW21_RS18370_lanthipeptideNZ_SPFW01000044.1 Lanthipeptides: FGQ81_RS16590_lanthipeptide

Lanthipeptides: JMK14_RS12260_lanthipeptide

1

QFCTSTKECNWGTIM

15

+ CT T EC TI+

18

RLCTGTAECPIMTII

32

19.2% NZ_CZAY01000009.1and 12 others:

NZ_CZBA01000009.1 Lanthipeptides: ARA06_RS08755_lanthipeptideNZ_CZBB01000003.1 Lanthipeptides: ARA29_RS04330_lanthipeptideNZ_JADPDU010000003.1 Lanthipeptides: I4V06_RS02990_lanthipeptideNZ_JAOQJU010000001.1 Lanthipeptides: OCV99_RS00835_lanthipeptideNZ_JAQCSY010000025.1 Lanthipeptides: PGZ10_RS13865_lanthipeptideNZ_JAQEDC010000020.1 Lanthipeptides: PHA23_RS12680_lanthipeptideNZ_QRZZ01000001.1 Lanthipeptides: DWV87_RS01465_lanthipeptideNZ_QSUB01000001.1 Lanthipeptides: DXB81_RS03120_lanthipeptideNZ_QUCI01000019.1 Lanthipeptides: DW648_RS14740_lanthipeptideNZ_QULD01000003.1 Lanthipeptides: DXB83_RS07060_lanthipeptideNZ_QULI01000007.1 Lanthipeptides: DXB71_RS08970_lanthipeptideNZ_SLZV01000043.1 Lanthipeptides: EDD74_RS14380_lanthipeptide

Lanthipeptides: ARA07_RS06830_lanthipeptide

2

FCTSTKECNWGTIMFVCC

19

CTST EC +GT++ CC

32

LCTSTAECYFGTLLKPCC

49

17.5% NZ_CM001792.1and 1 other:

NZ_CM001792.1 Lanthipeptides: C794_RS17980_lanthipeptide

Lanthipeptides: C794_RS17980_lanthipeptide

2

FCTSTKEC

9

FCT TKEC

26

FCTITKEC

33

17.1% NZ_FQZK01000006.1and 2 others:

NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13060_lanthipeptideNZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13060_lanthipeptide

Lanthipeptides: BUE45_RS13060_lanthipeptide

1

QFCTSTKECN

10

+FCT T ECN

26

RFCTVTVECN

35

16.7% NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21845_lanthipeptide

Lanthipeptides: CN325_RS21845_lanthipeptide

1

QFCTSTKEC

9

++CT++KEC

16

KYCTASKEC

24

15.8% NZ_BMRY01000003.1and 28 others:

NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptideNZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptideNZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptideNZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptide

Lanthipeptides: IE140_RS12370_lanthipeptide

1

QFCTSTKEC

9

FCT+T EC

25

NFCTATAEC

33

14.7% NZ_CAKMMP010000011.1and 5 others:

NZ_CP018620.1 Lanthipeptides: BS614_RS05680_lanthipeptideNZ_CP062165.1 Lanthipeptides: JNUCC31_RS16755_lanthipeptideNZ_FMVM01000006.1 Lanthipeptides: BLQ13_RS10365_lanthipeptideNZ_RIAS01000010.1 Lanthipeptides: EC604_RS18225_lanthipeptideNZ_VEJI01000010.1 Lanthipeptides: FS576_RS22075_lanthipeptide

Lanthipeptides: L6H98_RS19925_lanthipeptide

2

FCTSTKECNWGTI

14

FCT + EC++ ++

13

FCTVSHECHYNSV

25

allorf_0889319_0889417

Leader:

MIRSSIIFFVLNKLQGS

Core:

CQVSVRFLSEKYIIL

Core with dehydrations:

CysQVDhaVRFLDhaEKYIIL

antiSMASH-DB 4.0 matches for allorf_0889319_0889417

100.0% NZ_CP102267.1and 7 others:

NZ_JAQDBP010000004.1 Lanthipeptides: allorf_177044_177142_lanthipeptideNZ_JAQEHQ010000024.1 Lanthipeptides: allorf_20164_20253_lanthipeptideNZ_JAQESL010000043.1 Lanthipeptides: allorf_02084_02182_lanthipeptideNZ_JAQESS010000001.1 Lanthipeptides: allorf_017059_017148_lanthipeptideNZ_LN913006.1 Lanthipeptides: allorf_0097924_0098022_lanthipeptideNZ_QRPQ01000011.1 Lanthipeptides: allorf_103379_103477_lanthipeptideNZ_QSJW01000012.1 Lanthipeptides: allorf_092199_092297_lanthipeptide

Lanthipeptides: allorf_0889319_0889417_lanthipeptide

1

CQVSVRFLSEKYIIL

15

CQVSVRFLSEKYIIL

1

CQVSVRFLSEKYIIL

15

allorf_0904640_0904792

Leader:

MVISLHYIIGS

Core:

FTYTVRTEYVFILGEVRCTYCVSIGYCQRKVYGYKKSTD

Core with dehydrations:

FDhbYDhbVRDhbEYVFILGEVRCysDhbYCysVDhaIGYCysQRKVYGYKKDhaDhbD

MIBiG 3.1 matches for allorf_0904640_0904792

7.7% BGC0002110 (QKV49893.1): Lanthipeptide: birimositide

20

YCVSIGYCQRK

30

+C CQ

18

WCTLTKECQPN

28

antiSMASH-DB 4.0 matches for allorf_0904640_0904792

100.0% NZ_CP102267.1: Lanthipeptides: allorf_0904640_0904792_lanthipeptide

1

FTYTVRTEYVFILGEVRCTYCVSIGYCQRKVYGYKKSTD

39

FTYTVRTEYVFILGEVRCTYCVSIGYCQRKVYGYKKSTD

1

FTYTVRTEYVFILGEVRCTYCVSIGYCQRKVYGYKKSTD

39

20.5% NZ_CP011129.1: Lanthipeptides: allorf_3545239_3545370_lanthipeptide

4

TVRTEYVFILGEVRCTYCVSIG

25

T+ T + F RC C S G

5

TLATAHAFDQSRRRCKTCESRG

26

15.4% NZ_CP013140.1: Lanthipeptides: allorf_2670844_2670996_lanthipeptide

18

CTYCVSIGYCQ

28

CT CV G C+

10

CTPCVRAGACR

20

with 1 more sequence matches

12.8% NZ_CP036019.1and 1 other:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27195_lanthipeptide

Lanthipeptides: EXW52_RS27195_lanthipeptide

21

CVSIGYCQRKVY

32

+S+G C K+Y

17

AISVGLCPTKMY

28

allorf_0904958_0905074

Leader:

MKLISHVLPMSKEIKKSAKKTINMVVNAM

Core:

TWYKECTNT

Core with dehydrations:

DhbWYKECysDhbNDhb

antiSMASH-DB 4.0 matches for allorf_0904958_0905074

100.0% NZ_CP102267.1: Lanthipeptides: allorf_0904958_0905074_lanthipeptide

1

TWYKECTNT

9

TWYKECTNT

1

TWYKECTNT

9

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

ctg1_784 - Class II

Cleavage pHMM score: -6.40

RODEO score: 0

Monoisotopic mass: 2127.9 Da

Molecular weight: 2129.5 Da

Number of bridges: 4

allorf_0889319_0889417 - Class II

Cleavage pHMM score: -5.20

RODEO score: 0

Monoisotopic mass: 1761.0 Da

Molecular weight: 1762.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1780.1 Da N = 1

allorf_0904640_0904792 - Class II

Cleavage pHMM score: -4.00

RODEO score: 0

Monoisotopic mass: 4512.3 Da

Molecular weight: 4515.2 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 4533.2 Da N = 1; 4551.2 Da N = 2; 4569.2 Da N = 3; 4587.2 Da N = 4

allorf_0904958_0905074 - Class II

Cleavage pHMM score: -4.50

RODEO score: 0

Monoisotopic mass: 1090.5 Da

Molecular weight: 1091.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1109.2 Da N = 1; 1127.2 Da N = 2

gnlProkkaEDPMNEJH_1 - Region 3 - cyclic-lactone-autoinducer

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Location: 1,136,659 - 1,163,133 nt. (total: 26,475 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

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gnlProkkaEDPMNEJH_1 - Region 4 - cyclic-lactone-autoinducer

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Location: 1,213,997 - 1,234,401 nt. (total: 20,405 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

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gnlProkkaEDPMNEJH_1 - Region 5 - cyclic-lactone-autoinducer

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Location: 1,314,506 - 1,335,236 nt. (total: 20,731 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

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gnlProkkaEDPMNEJH_1 - Region 6 - cyclic-lactone-autoinducer

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Location: 1,465,636 - 1,486,369 nt. (total: 20,734 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

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gnlProkkaEDPMNEJH_1 - Region 7 - NRPS

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Location: 1,897,541 - 1,946,525 nt. (total: 48,985 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

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NRPS/PKS domains

KnownClusterBlast

NRPS/PKS modules

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		NT	AA		NT	AA

Detailed domain annotation

Selected features only

Show module domains

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Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 9, location 1897540 - 1946525:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - X - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg1_1713

AMP-binding (20..419): X

nrpys: Leu, Trp

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVLTDGGISK
Nearest Stachelhaus code(s):: Leu or Trp DVLTDGGISK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1033..1421): X

nrpys: Leu, Trp

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAMFSGAIFK
Nearest Stachelhaus code(s):: Leu or Trp DAMFSGAIFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2027..2418): X

nrpys: Leu, Trp

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAITTGGVSK
Nearest Stachelhaus code(s):: Leu or Trp DAITTGGVSK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

gnlProkkaEDPMNEJH_1 - Region 8 - cyclic-lactone-autoinducer

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Location: 2,164,991 - 2,185,560 nt. (total: 20,570 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

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gnlProkkaEDPMNEJH_1 - Region 9 - lanthipeptide-class-ii

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Location: 2,189,041 - 2,212,007 nt. (total: 22,967 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

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Similar known gene clusters from MIBiG 3.1

Lanthipeptide predictions

Lanthipeptide(s) for ctg1_1965

ctg1_1962

Leader:

MKTCSERNEQRINSLQLSESLEDEIKELDGKNVEAGDVIFT

Core:

TDTSSFLTIVCC

Core with dehydrations:

DhbDDhbDhaDhaFLDhbIVCysCys

antiSMASH-DB 4.0 matches for ctg1_1962

100.0% NZ_CP102267.1and 2 others:

NZ_JADMOE010000006.1 Lanthipeptides: I2G55_RS05425_lanthipeptideNZ_LT635469.1 Lanthipeptides: BQ7352_RS14540_lanthipeptide

Lanthipeptides: NQ550_RS10225_lanthipeptide

1

TDTSSFLTIVCC

12

TDTSSFLTIVCC

1

TDTSSFLTIVCC

12

50.0% NZ_CP113781.1: Lanthipeptides: GGADHKLB_RS14125_lanthipeptide

2

DTSSFLTIVCC

12

+ + FLTI+CC

2

NCTHFLTILCC

12

40.0% NZ_AP025566.1: Lanthipeptides: MWL92_RS00840_lanthipeptide

4

SSFLTIVCC

12

+SF TI+CC

7

TSFCTIICC

15

with 10 more sequence matches

33.3% NZ_CP036524.1: Lanthipeptides: LAJLEIBI_RS18025_lanthipeptide

4

SSFLTIVCC

12

++F TI+CC

7

TTFFTIICC

15

31.6% NZ_CP036170.1: Lanthipeptides: HDCHBGLK_RS18795_lanthipeptide

4

SSFLTIVCC

12

+FLTI CC

11

GTFLTIYCC

19

29.2% NZ_CP048626.1: Lanthipeptides: GXM18_RS04600_lanthipeptide

2

DTSSFLTIVCC

12

D +SF TI CC

14

DNASFFTIFCC

24

26.9% NZ_CP070036.1and 3 others:

NZ_JADMPO010000043.1 Lanthipeptides: I2I27_RS16805_lanthipeptideNZ_JADNGF010000061.1 Lanthipeptides: I2E06_RS15650_lanthipeptideNZ_JAQMLK010000037.1 Lanthipeptides: PNW18_RS16660_lanthipeptide

Lanthipeptides: I6K72_RS03970_lanthipeptide

4

SSFLTIVCC

12

S+FLTI CC

18

SAFLTIYCC

26

20.6% NZ_JADPCB010000035.1: Lanthipeptides: I4W51_RS14990_lanthipeptide

3

TSSFLTIVCC

12

T +FLTI+CC

25

TGAFLTILCC

34

17.9% NZ_CP094681.1: Lanthipeptides: K5I26_RS05295_lanthipeptide

1

TDTSSFLTIVCC

12

+D + FLTI CC

28

SDCALFLTIFCC

39

17.9% NZ_JAOQJV010000004.1: Lanthipeptides: OCV65_RS05205_lanthipeptide

4

SSFLTIVCC

12

S FLTI+CC

31

SGFLTIICC

39

17.6% NZ_MCGI01000004.1and 1 other:

NZ_MPDJ01000004.1 Lanthipeptides: BLA28_RS33805_lanthipeptide

Lanthipeptides: BEH84_RS33640_lanthipeptide

1

TDTSSFLTIVCC

12

T+++ FL+I CC

23

TESTPFLSIFCC

34

15.8% NZ_LT969517.1and 1 other:

NZ_QVLV01000012.1 Lanthipeptides: DXC51_RS29565_lanthipeptide

Lanthipeptides: C1733_RS32195_lanthipeptide

1

TDTSSFLTIVCC

12

T ++ FL+I CC

27

TASTGFLSIFCC

38

15.4% NZ_JADNBM010000025.1and 2 others:

NZ_JAQDZW010000013.1 Lanthipeptides: PGT55_RS13345_lanthipeptideNZ_QVMC01000003.1 Lanthipeptides: DWV46_RS15805_lanthipeptide

Lanthipeptides: I2A62_RS14145_lanthipeptide

4

SSFLTIVCC

12

++FLTI CC

31

TAFLTIFCC

39

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

ctg1_1962 - Class II

Cleavage pHMM score: -4.00

RODEO score: 0

Monoisotopic mass: 1198.6 Da

Molecular weight: 1199.4 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 1217.4 Da N = 1; 1235.4 Da N = 2; 1253.4 Da N = 3

gnlProkkaEDPMNEJH_1 - Region 10 - ranthipeptide

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Location: 2,715,265 - 2,736,853 nt. (total: 21,589 nt) Show pHMM detection rules used

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

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No matches found.

gnlProkkaEDPMNEJH_1 - Region 11 - lanthipeptide-class-ii

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Location: 3,300,589 - 3,323,282 nt. (total: 22,694 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

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Similar known gene clusters from MIBiG 3.1

No matches found.

Lanthipeptide predictions

Lanthipeptide(s) for ctg1_2988

ctg1_2989

Leader:

MNEMNDKIIGNVEKELDEIEIIDTESIEEKLSFIVYG

Core:

TIVCC

Core with dehydrations:

DhbIVCysCys

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

ctg1_2989 - Class II: Cleavage pHMM score: -5.90; RODEO score: 0; Monoisotopic mass: 519.2 Da; Molecular weight: 519.7 Da; Number of bridges: 1